Search Results - "Georges, Laurent"

The Landscape of long noncoding RNA classification by St. Laurent, Georges, Wahlestedt, Claes, Kapranov, Philipp

“…Highlights • ncRNAs constitute the majority of transcriptional output of the human genome. • Lack of functional knowledge of most of ncRNAs has led to…”
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Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase by Wahlestedt, Claes, Faghihi, Mohammad Ali, Modarresi, Farzaneh, Khalil, Ahmad M, Wood, Douglas E, Sahagan, Barbara G, Morgan, Todd E, Finch, Caleb E, St. Laurent III, Georges, Kenny, Paul J

“…BACE is an enzyme necessary for the generation of neurotoxic amyloid-β in Alzheimer's disease. Claes Wahlestedt and his colleagues identify a noncoding RNA…”
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Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation by Pastori, Chiara, Philipp Kapranov, Clara Penas, Veronica Peschansky, Claude-Henry Volmar, Jann N. Sarkaria, Amade Bregy, Ricardo Komotar, Georges St. Laurent, Nagi G. Ayad, Claes Wahlestedt

“…Bromodomain and extraterminal (BET) domain proteins have emerged as promising therapeutic targets in glioblastoma and many other cancers. Small molecule…”
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Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts by Magistri, Marco, Faghihi, Mohammad Ali, St Laurent, Georges, Wahlestedt, Claes

“…In the decade following the publication of the Human Genome, noncoding RNAs (ncRNAs) have reshaped our understanding of the broad landscape of genome…”
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Evidence for natural antisense transcript-mediated inhibition of microRNA function by Faghihi, Mohammad Ali, Zhang, Ming, Huang, Jia, Modarresi, Farzaneh, Van der Brug, Marcel P, Nalls, Michael A, Cookson, Mark R, St-Laurent, 3rd, Georges, Wahlestedt, Claes

“…MicroRNAs (miRNAs) have the potential to regulate diverse sets of mRNA targets. In addition, mammalian genomes contain numerous natural antisense transcripts,…”
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RNAseq analysis of treatment-dependent signaling changes during inflammation in a mouse cutaneous wound healing model by St. Laurent, Georges, Toma, Ian, Seilheimer, Bernd, Cesnulevicius, Konstantin, Schultz, Myron, Tackett, Michael, Zhou, Jianhua, Ri, Maxim, Shtokalo, Dmitry, Antonets, Denis, Jepson, Tisha, McCaffrey, Timothy A

“…Despite proven therapeutic effects in inflammatory conditions, the specific mechanisms of phytochemical therapies are not well understood. The transcriptome…”
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Biomarker discovery in attention deficit hyperactivity disorder: RNA sequencing of whole blood in discordant twin and case-controlled cohorts by McCaffrey, Timothy A, St Laurent, 3rd, Georges, Shtokalo, Dmitry, Antonets, Denis, Vyatkin, Yuri, Jones, Daniel, Battison, Eleanor, Nigg, Joel T

“…A variety of DNA-based methods have been applied to identify genetic markers of attention deficit hyperactivity disorder (ADHD), but the connection to…”
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Noncoding RNAs: couplers of analog and digital information in nervous system function? by St. Laurent, Georges, Wahlestedt, Claes

“…The mammalian nervous system expresses numerous noncoding RNAs (ncRNAs). We propose that ncRNAs are capable of coupling the digital information universe of…”
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Dark matter RNA illuminates the puzzle of genome-wide association studies by St Laurent, Georges, Vyatkin, Yuri, Kapranov, Philipp

“…In the past decade, numerous studies have made connections between sequence variants in human genomes and predisposition to complex diseases. However, most of…”
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Primary hepatocyte culture supports hepatitis C virus replication: A model for infection‐associated hepatocarcinogenesis by Banaudha, Krishna, Orenstein, Jan M., Korolnek, Tamara, St. Laurent, Georges C., Wakita, Takaji, Kumar, Ajit

“…Analysis of progressive changes in hepatic gene expression that underlie hepatocarcinogenesis following hepatitis C virus (HCV) infection require examination…”
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Dark Matter RNA: Existence, Function, and Controversy by Kapranov, Philipp, St Laurent, Georges

“…The mysteries surrounding the ∼97-98% of the human genome that does not encode proteins have long captivated imagination of scientists. Does the…”
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Identification of novel GLI1 target genes and regulatory circuits in human cancer cells by Diao, Yumei, Rahman, Mohammed Ferdous‐Ur, Vyatkin, Yuri, Azatyan, Ani, St. Laurent, Georges, Kapranov, Philipp, Zaphiropoulos, Peter G.

“…Hedgehog (HH) signaling is involved in many physiological processes, and pathway deregulation can result in a wide range of malignancies. Glioma‐associated…”
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Meta-analysis of microarray results: challenges, opportunities, and recommendations for standardization by Cahan, Patrick, Rovegno, Felicia, Mooney, Denise, Newman, John C., St. Laurent, Georges, McCaffrey, Timothy A.

“…Microarray profiling of gene expression is a powerful tool for discovery, but the ability to manage and compare the resulting data can be problematic…”
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RNA sequencing of blood in coronary artery disease: involvement of regulatory T cell imbalance by McCaffrey, Timothy A, Toma, Ian, Yang, Zhaoquing, Katz, Richard, Reiner, Jonathan, Mazhari, Ramesh, Shah, Palak, Tackett, Michael, Jones, Dan, Jepson, Tisha, Falk, Zachary, Wargodsky, Richard, Shtakalo, Dmitry, Antonets, Denis, Ertle, Justin, Kim, Ju H, Lai, Yinglei, Arslan, Zeynep, Aledort, Emily, Alfaraidy, Maha, Laurent, 3rd, Georges St

“…Cardiovascular disease had a global prevalence of 523 million cases and 18.6 million deaths in 2019. The current standard for diagnosing coronary artery…”
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Cardiovascular Inflammation and Lesion Cell Apoptosis: A Novel Connection via the Interferon-Inducible Immunoproteasome by Yang, Zhaoqing, Gagarin, Dmitry, St. Laurent, Georges, Hammell, Neil, Toma, Ian, Hu, Chien-an, Iwasa, Ayaka, McCaffrey, Timothy A

“…OBJECTIVE—Increasing evidence suggests that chronic inflammation contributes to atherogenesis, and that acute inflammatory events cause plaque rupture,…”
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Intronic RNAs constitute the major fraction of the non-coding RNA in mammalian cells by St Laurent, Georges, Shtokalo, Dmitry, Tackett, Michael R, Yang, Zhaoqing, Eremina, Tatyana, Wahlestedt, Claes, Urcuqui-Inchima, Silvio, Seilheimer, Bernd, McCaffrey, Timothy A, Kapranov, Philipp

“…The function of RNA from the non-coding (the so called "dark matter") regions of the genome has been a subject of considerable recent debate. Perhaps the most…”
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Demand response with active phase change material based thermal energy storage in buildings by Nunna, Aneesh Chandra, Zong, Yi, Georges, Laurent, You, Shi

“…A large potential to shift the electricity consumption to adapt to the stochastic renewable electricity generation is identified through the utilisation of a…”
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Economic and Energy Performance of Heating and Ventilation Systems in Deep Retrofitted Norwegian Detached Houses by Heide, Vegard, Thingbø, Håkon Selstad, Lien, Anne Gunnarshaug, Georges, Laurent

“…The aim of this study was to evaluate the life-cycle costs (LCC) and energy performance of different heating and ventilation systems (HVAC) in deep-energy…”
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Evaluation Method for the Hourly Average CO2eq. Intensity of the Electricity Mix and Its Application to the Demand Response of Residential Heating by Clauß, John, Stinner, Sebastian, Solli, Christian, Lindberg, Karen Byskov, Madsen, Henrik, Georges, Laurent

“…This work introduces a generic methodology to determine the hourly average CO2eq. intensity of the electricity mix of a bidding zone. The proposed method is…”
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Validation of the Energy Demand Load Profile Estimator “PROFet” for Trondheim Non-residential Buildings by Mohammadabadi, Abolfazl, Sartori, Igor, Georges, Laurent

“…Accurate long-term forecasts of aggregate energy load profiles are crucial for effective energy system planning at regional and national scales. This study…”
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