Search Results - "Georges, Amédée Des"

Structure of a mammalian ryanodine receptor by Zalk, Ran, Clarke, Oliver B., des Georges, Amédée, Grassucci, Robert A., Reiken, Steven, Mancia, Filippo, Hendrickson, Wayne A., Frank, Joachim, Marks, Andrew R.

“…Ryanodine receptors (RyRs) mediate the rapid release of calcium (Ca 2+ ) from intracellular stores into the cytosol, which is essential for numerous cellular…”
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Cryo-EM structure of the human ferritin–transferrin receptor 1 complex by Montemiglio, Linda Celeste, Testi, Claudia, Ceci, Pierpaolo, Falvo, Elisabetta, Pitea, Martina, Savino, Carmelinda, Arcovito, Alessandro, Peruzzi, Giovanna, Baiocco, Paola, Mancia, Filippo, Boffi, Alberto, des Georges, Amédée, Vallone, Beatrice

“…Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin. Arenaviruses and the malaria…”
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Structural Basis for Gating and Activation of RyR1 by des Georges, Amédée, Clarke, Oliver B., Zalk, Ran, Yuan, Qi, Condon, Kendall J., Grassucci, Robert A., Hendrickson, Wayne A., Marks, Andrew R., Frank, Joachim

“…The type-1 ryanodine receptor (RyR1) is an intracellular calcium (Ca2+) release channel required for skeletal muscle contraction. Here, we present cryo-EM…”
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Discovery of a Transferrin Receptor 1‑Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T‑Cell Therapy Manufacturing by Cheng, Emmeline L., Cardle, Ian I., Kacherovsky, Nataly, Bansia, Harsh, Wang, Tong, Zhou, Yunshi, Raman, Jai, Yen, Albert, Gutierrez, Dominique, Salipante, Stephen J., des Georges, Amédée, Jensen, Michael C., Pun, Suzie H.

“…The clinical manufacturing of chimeric antigen receptor (CAR) T cells includes cell selection, activation, gene transduction, and expansion. While the method…”
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Effect of Envelope Proteins on the Mechanical Properties of Influenza Virus by Schaap, Iwan A.T., Eghiaian, Frédéric, des Georges, Amédée, Veigel, Claudia

“…The envelope of the influenza virus undergoes extensive structural change during the viral life cycle. However, it is unknown how lipid and protein components…”
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Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster by Lende, Stine Sofie Frank, Barnkob, Nanna Møller, Hansen, Randi Westh, Bansia, Harsh, Vestergaard, Mike, Rothemejer, Frederik Holm, Worsaae, Anne, Brown, Deijona, Pedersen, Maria Lange, Rahimic, Anna Halling Folkmar, Juhl, Anna Karina, Gjetting, Torben, Østergaard, Lars, Georges, Amédée Des, Vuillard, Laurent-Michel, Schleimann, Mariane Høgsbjerg, Koefoed, Klaus, Tolstrup, Martin

“…Despite development of effective SARS-CoV-2 vaccines, a sub-group of vaccine non-responders depends on therapeutic antibodies or small-molecule drugs in cases…”
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Engineered ferritin for lanthanide binding by Calisti, Lorenzo, Trabuco, Matilde Cardoso, Boffi, Alberto, Testi, Claudia, Montemiglio, Linda Celeste, des Georges, Amédée, Benni, Irene, Ilari, Andrea, Taciak, Bartłomiej, Białasek, Maciej, Rygiel, Tomasz, Król, Magdalena, Baiocco, Paola, Bonamore, Alessandra

“…Ferritin H-homopolymers have been extensively used as nanocarriers for diverse applications in the targeted delivery of drugs and imaging agents, due to their…”
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Mal3, the Schizosaccharomyces pombe homolog of EB1, changes the microtubule lattice by des Georges, Amédée, Cross, Robert A, Amos, Linda A, Katsuki, Miho, Drummond, Douglas R, Osei, Michael

“…In vitro , pure tubulin assembles into B-lattice microtubules, in which lateral αα and ββ contacts between tubulin heterodimers predominate. Mal3, a homolog of…”
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Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells by Fedry, Juliette, Silva, Joana, Vanevic, Mihajlo, Fronik, Stanley, Mechulam, Yves, Schmitt, Emmanuelle, des Georges, Amédée, Faller, William James, Förster, Friedrich

“…Aberrantly slow ribosomes incur collisions, a sentinel of stress that triggers quality control, signaling, and translation attenuation. Although each collision…”
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Routine single particle CryoEM sample and grid characterization by tomography by Noble, Alex J, Dandey, Venkata P, Wei, Hui, Brasch, Julia, Chase, Jillian, Acharya, Priyamvada, Tan, Yong Zi, Zhang, Zhening, Kim, Laura Y, Scapin, Giovanna, Rapp, Micah, Eng, Edward T, Rice, William J, Cheng, Anchi, Negro, Carl J, Shapiro, Lawrence, Kwong, Peter D, Jeruzalmi, David, des Georges, Amedee, Potter, Clinton S, Carragher, Bridget

“…Single particle cryo-electron microscopy (cryoEM) is often performed under the assumption that particles are not adsorbed to the air-water interfaces and in…”
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Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29 by Hashem, Yaser, des Georges, Amedee, Dhote, Vidya, Langlois, Robert, Liao, Hstau Y., Grassucci, Robert A., Hellen, Christopher U.T., Pestova, Tatyana V., Frank, Joachim

“…Eukaryotic translation initiation begins with assembly of a 43S preinitiation complex. First, methionylated initiator methionine transfer RNA (Met-tRNAiMet),…”
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Human parainfluenza virus fusion complex glycoproteins imaged in action on authentic viral surfaces by Marcink, Tara C, Wang, Tong, des Georges, Amedee, Porotto, Matteo, Moscona, Anne

“…Infection by human parainfluenza viruses (HPIVs) causes widespread lower respiratory diseases, including croup, bronchiolitis, and pneumonia, and there are no…”
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Intermediates in SARS-CoV-2 spike-mediated cell entry by Marcink, Tara C, Kicmal, Thomas, Armbruster, Emily, Zhang, Zhening, Zipursky, Gillian, Golub, Kate L, Idris, Mohab, Khao, Jonathan, Drew-Bear, Jennifer, McGill, Gael, Gallagher, Tom, Porotto, Matteo, des Georges, Amédée, Moscona, Anne

“…SARS-CoV-2 cell entry is completed after viral spike (S) protein-mediated membrane fusion between viral and host cell membranes. Stable prefusion and…”
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Viral Entry Properties Required for Fitness in Humans Are Lost through Rapid Genomic Change during Viral Isolation by Iketani, Sho, Shean, Ryan C, Ferren, Marion, Makhsous, Negar, Aquino, Dolly B, des Georges, Amedee, Rima, Bert, Mathieu, Cyrille, Porotto, Matteo, Moscona, Anne, Greninger, Alexander L

“…Human parainfluenza viruses cause a large burden of human respiratory illness. While much research relies upon viruses grown in cultured immortalized cells,…”
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Mechanisms of opening and closing of the bacterial replicative helicase by Chase, Jillian, Catalano, Andrew, Noble, Alex J, Eng, Edward T, Olinares, Paul Db, Molloy, Kelly, Pakotiprapha, Danaya, Samuels, Martin, Chait, Brian, des Georges, Amedee, Jeruzalmi, David

“…Assembly of bacterial ring-shaped hexameric replicative helicases on single-stranded (ss) DNA requires specialized loading factors. However, mechanisms…”
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Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex by Nguyen, Anthony H., Thomsen, Alex R. B., Cahill, Thomas J., Huang, Rick, Huang, Li-Yin, Marcink, Tara, Clarke, Oliver B., Heissel, Søren, Masoudi, Ali, Ben-Hail, Danya, Samaan, Fadi, Dandey, Venkata P., Tan, Yong Zi, Hong, Chuan, Mahoney, Jacob P., Triest, Sarah, Little, John, Chen, Xin, Sunahara, Roger, Steyaert, Jan, Molina, Henrik, Yu, Zhiheng, des Georges, Amedee, Lefkowitz, Robert J.

“…Classically, G-protein-coupled receptors (GPCRs) are thought to activate G protein from the plasma membrane and are subsequently desensitized by β-arrestin…”
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Structure of mammalian eIF3 in the context of the 43S preinitiation complex by des Georges, Amedee, Dhote, Vidya, Kuhn, Lauriane, Hellen, Christopher U. T., Pestova, Tatyana V., Frank, Joachim, Hashem, Yaser

“…During eukaryotic translation initiation, 43S complexes, comprising a 40S ribosomal subunit, initiator transfer RNA and initiation factors (eIF) 2, 3, 1 and…”
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Retrieving functional pathways of biomolecules from single-particle snapshots by Dashti, Ali, Mashayekhi, Ghoncheh, Shekhar, Mrinal, Ben Hail, Danya, Salah, Salah, Schwander, Peter, des Georges, Amedee, Singharoy, Abhishek, Frank, Joachim, Ourmazd, Abbas

“…A primary reason for the intense interest in structural biology is the fact that knowledge of structure can elucidate macromolecular functions in living…”
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pH-tunable membrane-active polymers, NCMNP2a- x , and their potential membrane protein applications by Trinh, Thi Kim Hoang, Cabezas, Andres Jorge, Joshi, Soumil, Catalano, Claudio, Siddique, Abu Bakkar, Qiu, Weihua, Deshmukh, Sanket, des Georges, Amedee, Guo, Youzhong

“…Accurate 3D structures of membrane proteins are essential for comprehending their mechanisms of action and designing specific ligands to modulate their…”
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High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome by Hashem, Yaser, des Georges, Amedee, Fu, Jie, Buss, Sarah N., Jossinet, Fabrice, Jobe, Amy, Zhang, Qin, Liao, Hstau Y., Grassucci, Robert A., Bajaj, Chandrajit, Westhof, Eric, Madison-Antenucci, Susan, Frank, Joachim

“…High-resolution cryo-electron microscopy shows that the Trypanosoma brucei kinetoplastid ribosome is characterized by the presence of large expansion segments,…”
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