Search Results - "Georger, Mary A."

Targeting of the bone marrow microenvironment improves outcome in a murine model of myelodysplastic syndrome by Balderman, Sophia R., Li, Allison J., Hoffman, Corey M., Frisch, Benjamin J., Goodman, Alexandra N., LaMere, Mark W., Georger, Mary A., Evans, Andrew G., Liesveld, Jane L., Becker, Michael W., Calvi, Laura M.

“…In vitro evidence suggests that the bone marrow microenvironment (BMME) is altered in myelodysplastic syndromes (MDSs). Here, we study the BMME in MDS in vivo…”
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Prostaglandin E2 Increases Hematopoietic Stem Cell Survival and Accelerates Hematopoietic Recovery After Radiation Injury by Porter, Rebecca L., Georger, Mary A., Bromberg, Olga, McGrath, Kathleen E., Frisch, Benjamin J., Becker, Michael W., Calvi, Laura M.

“…Hematopoietic stem and progenitor cells (HSPCs), which continuously maintain all mature blood cells, are regulated within the marrow microenvironment. We…”
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The Smooth Muscle Cell-restricted KCNMB1 Ion Channel Subunit Is a Direct Transcriptional Target of Serum Response Factor and Myocardin by Long, Xiaochun, Tharp, Darla L., Georger, Mary A., Slivano, Orazio J., Lee, Monica Y., Wamhoff, Brian R., Bowles, Douglas K., Miano, Joseph M.

“…Large conductance calcium-activated potassium (MaxiK) channels play a pivotal role in maintaining normal arterial tone by regulating the excitation-contraction…”
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Restricted Inactivation of Serum Response Factor to the Cardiovascular System by Miano, Joseph M., Ramanan, Narendrakumar, Georger, Mary A., Karen L. de Mesy Bentley, Emerson, Rachael L., Balza, Robert O., Xiao, Qi, Weiler, Hartmut, Ginty, David D., Misra, Ravi P., Olson, Eric N.

“…Serum response factor (SRF) directs programs of gene expression linked to growth and muscle differentiation. To investigate the role of SRF in cardiovascular…”
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Axl, A Receptor Tyrosine Kinase, Mediates Flow-Induced Vascular Remodeling by Korshunov, Vyacheslav A, Mohan, Amy M, Georger, Mary A, Berk, Bradford C

“…Intima-media thickening (IMT) in response to hemodynamic stress is a physiological process that requires coordinated signaling among endothelial, inflammatory,…”
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Retinoid-induced expression and activity of an immediate early tumor suppressor gene in vascular smooth muscle cells by Streb, Jeffrey W, Long, Xiaochun, Lee, Ting-Hein, Sun, Qiang, Kitchen, Chad M, Georger, Mary A, Slivano, Orazio J, Blaner, William S, Carr, Daniel W, Gelman, Irwin H, Miano, Joseph M

“…Retinoids are used clinically to treat a number of hyper-proliferative disorders and have been shown in experimental animals to attenuate vascular occlusive…”
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The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool by Lawal, Rialnat A, Zhou, Xichao, Batey, Kaylind, Hoffman, Corey M, Georger, Mary A, Radtke, Freddy, Hilton, Matthew J, Xing, Lianping, Frisch, Benjamin J, Calvi, Laura M

“…ABSTRACT Notch signaling is critical for osteoblastic differentiation; however, the specific contribution of individual Notch ligands is unknown. Parathyroid…”
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The Chemokine CCL3 Regulates Myeloid Differentiation and Hematopoietic Stem Cell Numbers by Staversky, Rhonda J., Byun, Daniel K., Georger, Mary A., Zaffuto, Brandon J., Goodman, Alexandra, Becker, Michael W., Calvi, Laura M., Frisch, Benjamin J.

“…The chemokine CCL3 is frequently overexpressed in malignancies and overexpression leads to microenvironmental dysfunction. In murine models of chronic…”
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Expression and comparative genomics of two serum response factor genes in zebrafish by Davis, Jody L, Long, Xiaochun, Georger, Mary A, Scott, Ian C, Rich, Adam, Miano, Joseph M

“…Serum response factor (SRF) is a single copy, highly conserved transcription factor that governs the expression of hundreds of genes involved with actin…”
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Smooth Muscle Calponin: An Unconventional CArG-Dependent Gene That Antagonizes Neointimal Formation by Long, Xiaochun, Slivano, Orazio J, Cowan, Sarah L, Georger, Mary A, Lee, Ting-Hein, Miano, Joseph M

“…OBJECTIVE—Smooth muscle calponin (CNN1) contains multiple conserved intronic CArG elements that bind serum response factor and display enhancer activity in…”
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Tissue Expression of the Novel Serine Carboxypeptidase Scpep1 by Lee, Ting-Hein D, Streb, Jeffrey W, Georger, Mary A, Miano, Joseph M

“…We previously identified a novel gene designated retinoid-inducible serine carboxypeptidase (RISC or Scpep1). Here we characterize a polyclonal antibody raised…”
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CCL3 Regulates Normal Hematopoiesis but Is Not Essential for the Maintenance of a Long-Term Engrafting Hematopoietic Stem Cell by Staversky, Rhonda J., Yang, Lila, Goodman, Alexandra N., Georger, Mary A, Becker, Michael W., Calvi, Laura M., Frisch, Benjamin J.

“…Background/Rationale: Hematologic malignancies are known to remodel the bone marrow microenvironment, reducing support for normal hematopoiesis while…”
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CCL3 Signaling Is Essential for Leukemia Progression but Dispensable for Hematopoietic Stem Cell Maintenance by Staversky, Rhonda J., Georger, Mary A, Ackun-Farmmer, Marian, Becker, Michael W., Benoit, Danielle S.W., Calvi, Laura M., Frisch, Benjamin J.

“…Background: Hematologic malignancies remodel the bone marrow microenvironment (BMME), reducing support for normal hematopoiesis while increasing support for…”
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Prostaglandin E2 Inhibits Apoptosis in Hematopoietic Stem and Progenitor Cells and Enhances Their Survival Following Sub-Lethal Radiation Injury by Porter, Rebecca L, Georger, Mary A, Calvi, Laura M

“…Abstract 3401 Hematopoietic stem and progenitor cells (HSPCs) are responsible for the continual production of all mature blood cells during homeostasis and…”
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Abstract 985: BAC Transgenic Analysis of the Smooth Muscle Calponin Gene by Long, Xiaochun, Georger, Mary A, Liu, Vivian, Miano, Joseph M

“…Abstract only Regulatory elements controlling gene expression are often found in separate, sometimes remote, regions around gene loci. Artificial chromosomes…”
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