Search Results - "Georgeon, Sandrine"

De novo protein design enables the precise induction of RSV-neutralizing antibodies by Sesterhenn, Fabian, Yang, Che, Bonet, Jaume, Cramer, Johannes T, Wen, Xiaolin, Wang, Yimeng, Chiang, Chi-I, Abriata, Luciano A, Kucharska, Iga, Castoro, Giacomo, Vollers, Sabrina S, Galloux, Marie, Dheilly, Elie, Rosset, Stéphane, Corthésy, Patricia, Georgeon, Sandrine, Villard, Mélanie, Richard, Charles-Adrien, Descamps, Delphyne, Delgado, Teresa, Oricchio, Elisa, Rameix-Welti, Marie-Anne, Más, Vicente, Ervin, Sean, Eléouët, Jean-François, Riffault, Sabine, Bates, John T, Julien, Jean-Philippe, Li, Yuxing, Jardetzky, Theodore, Krey, Thomas, Correia, Bruno E

“…De novo protein design has been successful in expanding the natural protein repertoire. However, most de novo proteins lack biological function, presenting a…”
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Bottom-up de novo design of functional proteins with complex structural features by Yang, Che, Sesterhenn, Fabian, Bonet, Jaume, van Aalen, Eva A., Scheller, Leo, Abriata, Luciano A., Cramer, Johannes T., Wen, Xiaolin, Rosset, Stéphane, Georgeon, Sandrine, Jardetzky, Theodore, Krey, Thomas, Fussenegger, Martin, Merkx, Maarten, Correia, Bruno E.

“…De novo protein design has enabled the creation of new protein structures. However, the design of functional proteins has proved challenging, in part due to…”
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A rational blueprint for the design of chemically-controlled protein switches by Shui, Sailan, Gainza, Pablo, Scheller, Leo, Yang, Che, Kurumida, Yoichi, Rosset, Stéphane, Georgeon, Sandrine, Di Roberto, Raphaël B., Castellanos-Rueda, Rocío, Reddy, Sai T., Correia, Bruno E.

“…Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. However, the repertoire of small-molecule protein…”
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Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms by Duarte, Daniel P., Lamontanara, Allan J., La Sala, Giuseppina, Jeong, Sukyo, Sohn, Yoo-Kyoung, Panjkovich, Alejandro, Georgeon, Sandrine, Kükenshöner, Tim, Marcaida, Maria J., Pojer, Florence, De Vivo, Marco, Svergun, Dmitri, Kim, Hak-Sung, Dal Peraro, Matteo, Hantschel, Oliver

“…Bruton’s tyrosine kinase (Btk) is critical for B-cell maturation and activation. Btk loss-of-function mutations cause human X-linked agammaglobulinemia (XLA)…”
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Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains by Sha, Fern, Gencer, Emel Basak, Georgeon, Sandrine, Koide, Akiko, Yasui, Norihisa, Koide, Shohei, Hantschel, Oliver

“…The dysregulated tyrosine kinase BCR-ABL causes chronic myelogenous leukemia in humans and forms a large multiprotein complex that includes the Src-homology 2…”
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Single-molecule kinetic analysis of HP1-chromatin binding reveals a dynamic network of histone modification and DNA interactions by Bryan, Louise C, Weilandt, Daniel R, Bachmann, Andreas L, Kilic, Sinan, Lechner, Carolin C, Odermatt, Pascal D, Fantner, Georg E, Georgeon, Sandrine, Hantschel, Oliver, Hatzimanikatis, Vassily, Fierz, Beat

“…Chromatin recruitment of effector proteins involved in gene regulation depends on multivalent interaction with histone post-translational modifications (PTMs)…”
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The SH2 domain of Abl kinases regulates kinase autophosphorylation by controlling activation loop accessibility by Lamontanara, Allan Joaquim, Georgeon, Sandrine, Tria, Giancarlo, Svergun, Dmitri I., Hantschel, Oliver

“…The activity of protein kinases is regulated by multiple molecular mechanisms, and their disruption is a common driver of oncogenesis. A central and almost…”
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Computational design of anti-CRISPR proteins with improved inhibition potency by Mathony, Jan, Harteveld, Zander, Schmelas, Carolin, Upmeier zu Belzen, Julius, Aschenbrenner, Sabine, Sun, Wei, Hoffmann, Mareike D., Stengl, Christina, Scheck, Andreas, Georgeon, Sandrine, Rosset, Stéphane, Wang, Yanli, Grimm, Dirk, Eils, Roland, Correia, Bruno E., Niopek, Dominik

“…Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR–Cas technologies. However, the available Acr repertoire is limited to naturally occurring…”
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Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase by Reckel, Sina, Gehin, Charlotte, Tardivon, Delphine, Georgeon, Sandrine, Kükenshöner, Tim, Löhr, Frank, Koide, Akiko, Buchner, Lena, Panjkovich, Alejandro, Reynaud, Aline, Pinho, Sara, Gerig, Barbara, Svergun, Dmitri, Pojer, Florence, Güntert, Peter, Dötsch, Volker, Koide, Shohei, Gavin, Anne-Claude, Hantschel, Oliver

“…The two isoforms of the Bcr-Abl tyrosine kinase, p210 and p190, are associated with different leukemias and have a dramatically different signaling network,…”
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Enantioselective Enzymatic Reactions in Miniemulsions as Efficient "Nanoreactors" by Gröger, Harald, May, Oliver, Hüsken, Hendrik, Georgeon, Sandrine, Drauz, Karlheinz, Landfester, Katharina

“…Phasing in: Miniemulsions are homogenous mixtures in which the organic phase is dispersed in the form of nanometer‐scale droplets, which can act as efficient…”
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De novo design of protein interactions with learned surface fingerprints by Gainza, Pablo, Wehrle, Sarah, Van Hall-Beauvais, Alexandra, Marchand, Anthony, Scheck, Andreas, Harteveld, Zander, Buckley, Stephen, Ni, Dongchun, Tan, Shuguang, Sverrisson, Freyr, Goverde, Casper, Turelli, Priscilla, Raclot, Charlène, Teslenko, Alexandra, Pacesa, Martin, Rosset, Stéphane, Georgeon, Sandrine, Marsden, Jane, Petruzzella, Aaron, Liu, Kefang, Xu, Zepeng, Chai, Yan, Han, Pu, Gao, George F., Oricchio, Elisa, Fierz, Beat, Trono, Didier, Stahlberg, Henning, Bronstein, Michael, Correia, Bruno E.

“…Physical interactions between proteins are essential for most biological processes governing life 1 . However, the molecular determinants of such interactions…”
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c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease by Mahul-Mellier, Anne-Laure, Fauvet, Bruno, Gysbers, Amanda, Dikiy, Igor, Oueslati, Abid, Georgeon, Sandrine, Lamontanara, Allan J., Bisquertt, Alejandro, Eliezer, David, Masliah, Eliezer, Halliday, Glenda, Hantschel, Oliver, Lashuel, Hilal A.

“…Increasing evidence suggests that the c-Abl protein tyrosine kinase could play a role in the pathogenesis of Parkinson's disease (PD) and other…”
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Dual ON/OFF-switch chimeric antigen receptor controlled by two clinically approved drugs by Giordano Attianese, Greta Maria Paola, Shui, Sailan, Cribioli, Elisabetta, Triboulet, Melanie, Scheller, Leo, Hafezi, Morteza, Reichenbach, Patrick, Gainza, Pablo, Georgeon, Sandrine, Correia, Bruno E, Irving, Melita

“…The ability to remotely control the activity of chimeric antigen receptors (CARs) with small molecules can improve the safety and efficacy of gene-modified T…”
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Rational Design of Chemically Controlled Antibodies and Protein Therapeutics by Marchand, Anthony, Bonati, Lucia, Shui, Sailan, Scheller, Leo, Gainza, Pablo, Rosset, Stéphane, Georgeon, Sandrine, Tang, Li, Correia, Bruno E.

“…Protein-based therapeutics, such as monoclonal antibodies and cytokines, are important therapies for various pathophysiological conditions such as oncology,…”
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Antibody–peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins by Petruzzella, Aaron, Bruand, Marine, Santamaria-Martínez, Albert, Katanayeva, Natalya, Reymond, Luc, Wehrle, Sarah, Georgeon, Sandrine, Inel, Damla, van Dalen, Floris J., Viertl, David, Lau, Kelvin, Pojer, Florence, Schottelius, Margret, Zoete, Vincent, Verdoes, Martijn, Arber, Caroline, Correia, Bruno E., Oricchio, Elisa

“…Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the treatment of different cancers and other diseases. However, no…”
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Computational design of soluble and functional membrane protein analogues by Goverde, Casper A., Pacesa, Martin, Goldbach, Nicolas, Dornfeld, Lars J., Balbi, Petra E. M., Georgeon, Sandrine, Rosset, Stéphane, Kapoor, Srajan, Choudhury, Jagrity, Dauparas, Justas, Schellhaas, Christian, Kozlov, Simon, Baker, David, Ovchinnikov, Sergey, Vecchio, Alex J., Correia, Bruno E.

“…De novo design of complex protein folds using solely computational means remains a substantial challenge 1 . Here we use a robust deep learning pipeline to…”
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Rapid Screen for Tyrosine Kinase Inhibitor Resistance Mutations and Substrate Specificity by Taft, Joseph M, Georgeon, Sandrine, Allen, Chris, Reckel, Sina, DeSautelle, Joseph, Hantschel, Oliver, Georgiou, George, Iverson, Brent L

“…We present a rapid and high-throughput yeast and flow cytometry based method for predicting kinase inhibitor resistance mutations and determining kinase…”
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Exploring "dark-matter" protein folds using deep learning by Harteveld, Zander, Van Hall-Beauvais, Alexandra, Morozova, Irina, Southern, Joshua, Goverde, Casper, Georgeon, Sandrine, Rosset, Stéphane, Defferrard, Michëal, Loukas, Andreas, Vandergheynst, Pierre, Bronstein, Michael M, Correia, Bruno E

“…De novo protein design explores uncharted sequence and structure space to generate novel proteins not sampled by evolution. A main challenge in de novo design…”
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The SH2 Domain of BCR-ABL1 Regulates Kinase Autophosphorylation By Controlling Activation Loop Accessibility by Hantschel, Oliver D., Lamontanara, Allan Joaquim, Georgeon, Sandrine, Tria, Giancarlo, Svergun, Dmitri

“…Chronic myelogenous leukemia (CML) is caused by BCR-ABL1, which is a constitutively active form of the Abelson tyrosine kinase (ABL1). While treatment with the…”
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Iron bioavailability from fresh cheese fortified with iron-enriched yeast by Sabatier, Magalie, Egli, Ines, Hurrell, Richard, Hoppler, Mathias, Gysler, Christof, Georgeon, Sandrine, Mukherje, Rajat, Richon, Pierre-Alain, Vigo, Mario, Foman, Jasmin Tajeri, Zeder, Christophe, Schaffer-Lequart, Christelle

“…Purpose An iron-enriched yeast able to lyse at body temperature was developed for iron fortification of chilled dairy products. The aim was to evaluate iron…”
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