Search Results - "George S. Abela"

Viewing atherosclerosis through a crystal lens: How the evolving structure of cholesterol crystals in atherosclerotic plaque alters its stability by Nidorf, Stefan Mark, Fiolet, Aernoud, Abela, George S.

“…Reducing the residual risk of cardiovascular (CV) events in patients with atherosclerosis continues to be a challenge. Thus, understanding how cholesterol…”
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Cholesterol crystals piercing the arterial plaque and intima trigger local and systemic inflammation by Abela, George S., MD, MSc

“…Abstract The response to arterial wall injury is an inflammatory process, which over time becomes integral to the development of atherosclerosis and subsequent…”
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Interaction between bacteria and cholesterol crystals: Implications for endocarditis and atherosclerosis by Boumegouas, Manel, Raju, Manjunath, Gardiner, Joseph, Hammer, Neal, Saleh, Yehia, Al-Abcha, Abdullah, Kalra, Apoorv, Abela, George S

“…The interaction between pathogenic bacteria and cholesterol crystals (CCs) has not been investigated. However, CCs are found extensively in atherosclerotic…”
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Effect of Statins on Cholesterol Crystallization and Atherosclerotic Plaque Stabilization by Abela, George S., MD, Vedre, Ameeth, MD, Janoudi, Abed, PhD, Huang, Ruiping, PhD, Durga, Sridevi, MD, Tamhane, Umesh, MD

“…Pleiotropic effects of statins have not been fully elucidated. Recently we demonstrated that cholesterol expands when crystallizing and may trigger plaque…”
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Accelerated Atherosclerotic Calcification and Mönckeberg's Sclerosis: A Continuum of Advanced Vascular Pathology in Chronic Kidney Disease by McCullough, Peter A, Agrawal, Varun, Danielewicz, Ewa, Abela, George S

“…Autopsy studies have demonstrated the near universal presence of fatty streaks and fibroatheromas in the general population from which patients with chronic…”
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The Role of Direct Oral Anticoagulants Versus Vitamin K Antagonists in the Treatment of Left Ventricular Thrombi: A Meta-Analysis and Systematic Review by Al-abcha, Abdullah, Herzallah, Khader, Saleh, Yehia, Mujer, Mark, Abdelkarim, Ola, Abdelnabi, Mahmoud, Almaghraby, Abdallah, Abela, George S.

“…Background Direct oral anticoagulants (DOACs) have a well-established role in the treatment of deep vein thrombosis and pulmonary embolism and in the reduction…”
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Effect of Cholesterol Crystals on Plaques and Intima in Arteries of Patients With Acute Coronary and Cerebrovascular Syndromes by Abela, George S., MD, MSc, Aziz, Kusai, MD, Vedre, Ameeth, MD, Pathak, Dorothy R., PhD, Talbott, John D., DO, DeJong, Joyce, DO

“…Plaque disruption (PD) causes most acute cardiovascular events. Although cholesterol crystals (CCs) have been observed in plaques, their role in PD was…”
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Role of cholesterol crystals in atherosclerosis is unmasked by altering tissue preparation methods by Nasiri, Mojdeh, Janoudi, Abed, Vanderberg, Abigail, Frame, Melinda, Flegler, Carol, Flegler, Stanley, Abela, George S.

“…ABSTRACT Standard tissue preparation for light and scanning electron microscopy (SEM) uses ethanol as a dehydrating agent but that can also dissolve…”
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The effect of colchicine on cholesterol crystal formation, expansion and morphology: a potential mechanism in atherosclerosis by Abideen, Zain Ul, Pathak, Dorothy R, Sabanci, Rand, Manu, Megan, Abela, George S

“…Inflammation is pivotal to the progression of atherosclerosis. Cholesterol crystals (CCs) that grow and enlarge within the plaque core can cause plaque rupture…”
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The role of cholesterol crystals and ocular crystal emboli in retinal pathology by Medawar, Nicholas G., Dorweiler, Tim F., Abela, George S., Busik, Julia V., Grant, Maria B.

“…Cholesterol crystals (CC) can be responsible for a range of clinical syndromes in the retina from asymptomatic plaques to retinal artery occlusion with…”
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Effect of aspirin on cholesterol crystallization: A potential mechanism for plaque stabilization by Fry, Levi, Lee, Andre, Khan, Shaza, Aziz, Kusai, Vedre, Ameeth, Abela, George S.

“…Cholesterol crystals (CCs) have been found to be critical in the evolution and progression of atherosclerotic plaque leading up to rupture. This includes…”
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Cholesterol crystal embolization following plaque rupture： a systemic disease with unusual features by Ghanem, Firas, Vodnala, Deepthi, K Kalavakunta, Jagadeesh, Durga, Sridevi, Thormeier, Noah, Subramaniyam, Prem, Abela, Scott, S Abela, George

“…Cholesterol crystal embolic （CCE） syndrome is often a clinically challenging condition that has a poor prognostic implication. It is a result of plaque rupture…”
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Cholesterol induced heart valve inflammation and injury: efficacy of cholesterol lowering treatment by El-Khatib, Layan A, De Feijter-Rupp, Heather, Janoudi, Abed, Fry, Levi, Kehdi, Michael, Abela, George S

“…BackgroundHeart valves often undergo a degenerative process leading to mechanical dysfunction that requires valve replacement. This process has been compared…”
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Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque by Janoudi, Abed, Shamoun, Fadi E, Kalavakunta, Jagadeesh K, Abela, George S

“…Evolution of plaque that is prone to rupture is characterized by inflammation and physical changes. Accumulation of low-density lipoprotein in the sub-intima…”
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Cholesterol crystals induce mechanical trauma, inflammation, and neo-vascularization in solid cancers as in atherosclerosis by Abela, George S., Katkoori, Venkat R., Pathak, Dorothy R., Bumpers, Harvey L., Leja, Monika, ul Abideen, Zain, Boumegouas, Manel, Perry, Daniel, Al-Janadi, Anas, Richard, James E., Barnaba, Carlo, Medina Meza, Ilce G.

“…Cancer and atherosclerosis share common risk factors and inflammatory pathways that promote their proliferation via vascular endothelial growth factor (VEGF)…”
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Cardiovascular Manifestations in Human Immunodeficiency Virus-Infected Patients by Khunnawat, Chotikorn, MD, Mukerji, Siddharth, MD, Havlichek, Daniel, MD, Touma, Rabih, MD, Abela, George S., MD

“…Human immunodeficiency virus (HIV) is now a pandemic. It afflicts multiple organs, including the cardiovascular system. This occurs by direct invasion as well…”
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The rare presentation of the de Winter's pattern: Case report and literature review by Prasad, Rohan Madhu, Al-abcha, Abdullah, Elshafie, Ahmed, Radwan, Yasser Amr, Baloch, Zulfiqar Qutrio, Abela, George S.

“…Although not classified as a ST elevated myocardial infarction (STEMI), the patterns known as equivalents also require prompt recognition and treatment. A…”
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Anthracycline-induced cardiotoxicity: mechanisms of action, incidence, risk factors, prevention, and treatment by Saleh, Yehia, Abdelkarim, Ola, Herzallah, Khader, Abela, George S.

“…Anthracycline is a mainstay in treatment of many cancers including lymphoma and breast cancer among many others. However, anthracycline treatment can be…”
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The impact of statin therapy and aerobic exercise training on skeletal muscle and whole-body aerobic capacity by Slade, Jill M., Abela, George S., Rozman, Mitchell, McClowry, Robert J., Hurley, David, Forbes, Sean C., Meyer, Ronald A.

“…Statin use is widely recognized for improving cardiovascular health, but questions remain on how statin use influences skeletal muscle, particularly…”
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Potassium Toxicity at Low Serum Potassium Levels With Refeeding Syndrome by Vemula, Praveen, MD, MPH, Abela, Oliver G., MD, Narisetty, Keerthy, MD, Rhine, David, MD, Abela, George S., MD, MSc

“…Refeeding syndrome is a life-threatening condition occurring in severely malnourished patients after initiating feeding. Severe hypophosphatemia with reduced…”
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