Search Results - "George P Patrinos"

Human genetic factors associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity by Anastassopoulou, Cleo, Gkizarioti, Zoi, Patrinos, George P, Tsakris, Athanasios

“…The emergence of the novel coronavirus in Wuhan, Hubei Province, China, in December 2019 marked the synchronization of the world to a peculiar clock that is…”
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Updates of the HbVar database of human hemoglobin variants and thalassemia mutations by Giardine, Belinda, Borg, Joseph, Viennas, Emmanouil, Pavlidis, Cristiana, Moradkhani, Kamran, Joly, Philippe, Bartsakoulia, Marina, Riemer, Cathy, Miller, Webb, Tzimas, Giannis, Wajcman, Henri, Hardison, Ross C, Patrinos, George P

“…HbVar (http://globin.bx.psu.edu/hbvar) is one of the oldest and most appreciated locus-specific databases launched in 2001 by a multi-center academic effort to…”
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Triangulating nutrigenomics, metabolomics and microbiomics toward personalized nutrition and healthy living by Lagoumintzis, George, Patrinos, George P

“…The unique physiological and genetic characteristics of individuals influence their reactions to different dietary constituents and nutrients. This notion is…”
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Discovery of new drug indications for COVID-19: A drug repurposing approach by Kumari, Priyanka, Pradhan, Bikram, Koromina, Maria, Patrinos, George P, Steen, Kristel Van

“…The outbreak of coronavirus health issues caused by COVID-19(SARS-CoV-2) creates a global threat to public health. Therefore, there is a need for effective…”
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Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene by Sosnay, Patrick R, Siklosi, Karen R, Van Goor, Fredrick, Kaniecki, Kyle, Yu, Haihui, Sharma, Neeraj, Ramalho, Anabela S, Amaral, Margarida D, Dorfman, Ruslan, Zielenski, Julian, Masica, David L, Karchin, Rachel, Millen, Linda, Thomas, Philip J, Patrinos, George P, Corey, Mary, Lewis, Michelle H, Rommens, Johanna M, Castellani, Carlo, Penland, Christopher M, Cutting, Garry R

“…Garry Cutting and colleagues report a comprehensive functional and clinical analysis of CFTR variants reported in cystic fibrosis. They determine that 128 of…”
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Computational approaches in target identification and drug discovery by Katsila, Theodora, Spyroulias, Georgios A., Patrinos, George P., Matsoukas, Minos-Timotheos

“…In the big data era, voluminous datasets are routinely acquired, stored and analyzed with the aim to inform biomedical discoveries and validate hypotheses. No…”
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Medical education in pharmacogenomics—results from a survey on pharmacogenetic knowledge in healthcare professionals within the European pharmacogenomics clinical implementation project Ubiquitous Pharmacogenomics (U-PGx) by Just, Katja Susanne, Steffens, Michael, Swen, Jesse Joachim, Patrinos, George P., Guchelaar, Henk-Jan, Stingl, Julia Carolin

“…Purpose Due to the diversity within Europe, the implementation of pharmacogenomic testing in clinical practice faces specific challenges. In the context of the…”
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Gene conversion: mechanisms, evolution and human disease by Chen, Jian-Min, Patrinos, George P, Cooper, David N, Chuzhanova, Nadia, Férec, Claude

“…Gene conversion, one of the two mechanisms of homologous recombination, involves the unidirectional transfer of genetic material from a 'donor' sequence to a…”
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Editorial: Pharmacogenomics and ethnicity: Prevalence and clinical significance of pharmacogenomic biomarkers in indigenous and other populations by Patrinos, George P, Quinones, Luis Abel, Sukasem, Chonlaphat

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Cost-utility analysis and cross-country comparison of pharmacogenomics-guided treatment in colorectal cancer patients participating in the U-PGx PREPARE study by Fragoulakis, Vasileios, Roncato, Rossana, Bignucolo, Alessia, Patrinos, George P., Toffoli, Giuseppe, Cecchin, Erika, Mitropoulou, Christina

“…OBJECTIVESA cost-utility analysis was conducted to evaluate pharmacogenomic (PGx)-guided treatment compared to the standard-of-care intervention among patients…”
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Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants by Perkins, Andrew, Xu, Xiangmin, Higgs, Douglas R., Patrinos, George P., Arnaud, Lionel, Bieker, James J., Philipsen, Sjaak

“…Until recently our approach to analyzing human genetic diseases has been to accurately phenotype patients and sequence the genes known to be associated with…”
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Editorial: Integration of computational genomics into clinical pharmacogenomic tests: how bioinformatics may help primary care in precision medicine area by Tafazoli, Alireza, Abbaszadegan, Mohammad Reza, Patrinos, George P.

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Exploring public genomics data for population pharmacogenomics by Lakiotaki, Kleanthi, Kanterakis, Alexandros, Kartsaki, Evgenia, Katsila, Theodora, Patrinos, George P, Potamias, George

“…Racial and ethnic differences in drug responses are now well studied and documented. Pharmacogenomics research seeks to unravel the genetic underpinnings of…”
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A qualitative approach to assess the opinion of physicians about the challenges and prospects of pharmacogenomic testing implementation in clinical practice in Greece by Koufaki, Margarita-Ioanna, Patrinos, George P, Vasileiou, Konstantinos Z

“…Pharmacogenomics (PGx) constitutes an important part of personalized medicine and has several clinical applications. PGx role in clinical practice is known,…”
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PARC report: health outcomes and value of personalized medicine interventions: impact on patient care by Mitropoulou, Christina, Litinski, Veronika, Kabakchiev, Boyko, Rogers, Sara, P Patrinos, George

“…The incorporation of personalized medicine interventions into routine healthcare constitutes an opportunity to improve patients' quality of life, as it…”
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Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin by Papadopoulos, Petros, Gutiérrez, Laura, Scerri, Christian A, van IJcken, Wilfred, von Lindern, Marieke, Cassar, Wilhelmina, Felice, Alex E, Grech, Godfrey, Hou, Jun, Fanis, Pavlos, Phylactides, Marios, Georgitsi, Marianthi, Verkerk, Annemieke J M H, Özgür, Zeliha, Bugeja, Marisa, van der Spek, Peter J, Patrinos, George P, Borg, Joseph, Galdies, Ruth, Grosveld, Frank G, Gillemans, Nynke, Philipsen, Sjaak

“…Hereditary persistence of fetal hemoglobin (HPFH) is characterized by persistent high levels of fetal hemoglobin (HbF) in adults. Several contributory factors,…”
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RD-Connect: An Integrated Platform Connecting Databases, Registries, Biobanks and Clinical Bioinformatics for Rare Disease Research by Thompson, Rachel, Johnston, Louise, Taruscio, Domenica, Monaco, Lucia, Béroud, Christophe, Gut, Ivo G., Hansson, Mats G., ’t Hoen, Peter-Bram A., Patrinos, George P., Dawkins, Hugh, Ensini, Monica, Zatloukal, Kurt, Koubi, David, Heslop, Emma, Paschall, Justin E., Posada, Manuel, Robinson, Peter N., Bushby, Kate, Lochmüller, Hanns

“…ABSTRACT Research into rare diseases is typically fragmented by data type and disease. Individual efforts often have poor interoperability and do not…”
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Editorial: Translation and implementation of pharmacogenomic testing in daily clinical practice: Considering current challenges and future needs by Miltyk, Wojciech, Patrinos, George P., Verstuyft, Celine, Coenen, Marieke, Tafazoli, Alireza

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Editorial: Brief research reports in pharmacogenetics and pharmacogenomics: 2022 by Sessa, Francesco, Magdy, Tarek, Sukasem, Chonlaphat, Patrinos, George P

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VEGF-A and ICAM-1 Gene Polymorphisms as Predictors of Clinical Outcome to First-Line Bevacizumab-Based Treatment in Metastatic Colorectal Cancer by Papachristos, Apostolos, Kemos, Polychronis, Katsila, Theodora, Panoilia, Eirini, Patrinos, George P, Kalofonos, Haralabos, Sivolapenko, Gregory B

“…Bevacizumab is used to treat metastatic colorectal cancer (mCRC). However, there are still no available predictors of clinical outcomes. We investigated…”
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