Search Results - "George Birchenough"

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion by Birchenough, George M. H., Nyström, Elisabeth E. L., Johansson, Malin E. V., Hansson, Gunnar C.

“…Innate immune signaling pathways contribute to the protection of host tissue when bacterially challenged. Colonic goblet cells are responsible for generating…”
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Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration by Schroeder, Bjoern O., Birchenough, George M.H., Ståhlman, Marcus, Arike, Liisa, Johansson, Malin E.V., Hansson, Gunnar C., Bäckhed, Fredrik

“…Diet strongly affects gut microbiota composition, and gut bacteria can influence the colonic mucus layer, a physical barrier that separates trillions of gut…”
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An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function by Nyström, Elisabeth E L, Martinez-Abad, Beatriz, Arike, Liisa, Birchenough, George M H, Nonnecke, Eric B, Castillo, Patricia A, Svensson, Frida, Bevins, Charles L, Hansson, Gunnar C, Johansson, Malin E V

“…The intestinal mucus layer, an important element of epithelial protection, is produced by goblet cells. Intestinal goblet cells are assumed to be a homogeneous…”
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The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system by Pelaseyed, Thaher, Bergström, Joakim H., Gustafsson, Jenny K., Ermund, Anna, Birchenough, George M. H., Schütte, André, van der Post, Sjoerd, Svensson, Frida, Rodríguez-Piñeiro, Ana M., Nyström, Elisabeth E. L., Wising, Catharina, Johansson, Malin E. V., Hansson, Gunnar C.

“…Summary The gastrointestinal tract is covered by mucus that has different properties in the stomach, small intestine, and colon. The large highly glycosylated…”
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Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16 by Bergström, Joakim H., Birchenough, George M. H., Katona, Gergely, Schroeder, Bjoern O., Schütte, André, Ermund, Anna, Johansson, Malin E. V., Hansson, Gunnar C.

“…The distal colon functions as a bioreactor and harbors an enormous amount of bacteria in a mutualistic relationship with the host. The microbiota have to be…”
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NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation by van der Post, Sjoerd, Birchenough, George M.H., Held, Jason M.

“…The colon epithelium is a primary point of interaction with the microbiome and is regenerated by a few rapidly cycling colonic stem cells (CSCs). CSC…”
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Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer by Sharpen, Jack D. A., Dolan, Brendan, Nyström, Elisabeth E. L., Birchenough, George M. H., Arike, Liisa, Martinez-Abad, Beatriz, Johansson, Malin E. V., Hansson, Gunnar C., Recktenwald, Christian V.

“…The colonic mucus layer is organized as a two-layered system providing a physical barrier against pathogens and simultaneously harboring the commensal flora…”
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The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function by Volk, Joana K, Nyström, Elisabeth E L, van der Post, Sjoerd, Abad, Beatriz M, Schroeder, Bjoern O, Johansson, Åsa, Svensson, Frida, Jäverfelt, Sofia, Johansson, Malin E V, Hansson, Gunnar C, Birchenough, George M H

“…The inner mucus layer (IML) is a critical barrier that protects the colonic epithelium from luminal threats and inflammatory bowel disease. Innate immune…”
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Forming a mucus barrier along the colon by Birchenough, George M. H., Johansson, Malin E. V.

“…Optimal barrier function requires both proximal colon– and distal colon–derived mucus The intestine is exposed to numerous hazards and is heavily colonized by…”
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Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice by Schroeder, Bjoern O., Birchenough, George M.H., Pradhan, Meenakshi, Nyström, Elisabeth E.L., Henricsson, Marcus, Hansson, Gunnar C., Bäckhed, Fredrik

“…The intestinal mucus layer is a physical barrier separating the tremendous number of gut bacteria from the host epithelium. Defects in the mucus layer have…”
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Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation by Song, Ran, McAlpine, William, Fond, Aaron M., Nair-Gill, Evan, Choi, Jin Huk, Nyström, Elisabeth E. L., Arike, Liisa, Field, Sydney, Li, Xiaohong, SoRelle, Jeffrey A., Moresco, James J., Moresco, Eva Marie Y., Yates, John R., Azadi, Parastoo, Ni, Josephine, Birchenough, George M. H., Beutler, Bruce, Turer, Emre E.

“…A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel…”
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Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection by Birchenough, George M.H., Schroeder, Bjoern O., Sharba, Sinan, Arike, Liisa, Recktenwald, Christian V., Puértolas-Balint, Fabiola, Subramani, Mahadevan V., Hansson, Karl T., Yilmaz, Bahtiyar, Lindén, Sara K., Bäckhed, Fredrik, Hansson, Gunnar C.

“…Intestinal mucus barriers normally prevent microbial infections but are sensitive to diet-dependent changes in the luminal environment. Here we demonstrate…”
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New developments in goblet cell mucus secretion and function by Birchenough, G M H, Johansson, M EV, Gustafsson, J K, Bergström, J H, Hansson, G C

“…Goblet cells and their main secretory product, mucus, have long been poorly appreciated; however, recent discoveries have changed this and placed these cells…”
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Rainbow trout gastrointestinal mucus, mucin production, mucin glycosylation and response to lipopolysaccharide by Sharba, Sinan, Sundh, Henrik, Sundell, Kristina, Benktander, John, Santos, Licinia, Birchenough, George, Lindén, Sara K.

“…Mucus, whereof the highly glycosylated mucins are a major component, protects the epithelial mucosal surfaces. The aim of this study was to characterize the…”
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Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier by Birchenough, George, Schroeder, Bjoern O., Bäckhed, Fredrik, Hansson, Gunnar C.

“…It has long been acknowledged that dietary fibres are important to maintain a healthy gut. Over the past decade, several studies have shown that loss of…”
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Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity by Nyström, Elisabeth E.L., Birchenough, George M.H., van der Post, Sjoerd, Arike, Liisa, Gruber, Achim D., Hansson, Gunnar C., Johansson, Malin E.V.

“…Many epithelial surfaces of the body are covered with protective mucus, and disrupted mucus homeostasis is coupled to diseases such as ulcerative colitis,…”
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Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse colons by Arnesen, Henriette, Markussen, Turhan, Birchenough, George, Birkeland, Signe, Nyström, Elisabeth E. L., Hansson, Gunnar C., Carlsen, Harald, Boysen, Preben

“…To close the gap between ultra-hygienic research mouse models and the much more environmentally exposed conditions of humans, we have established a system…”
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The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice by Erickson, Nancy A, Nyström, Elisabeth E L, Mundhenk, Lars, Arike, Liisa, Glauben, Rainer, Heimesaat, Markus M, Fischer, André, Bereswill, Stefan, Birchenough, George M H, Gruber, Achim D, Johansson, Malin E V

“…The secreted, goblet cell-derived protein Clca1 (chloride channel regulator, calcium-activated-1) has been linked to diseases with mucus overproduction,…”
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Loss of Trefoil Factor 2 Sensitizes Rat Pups to Systemic Infection with the Neonatal Pathogen Escherichia coli K1 by McCarthy, Alex J, Birchenough, George M H, Taylor, Peter W

“…Gastrointestinal (GI) colonization of 2-day-old (P2) rat pups with K1 results in translocation of the colonizing bacteria across the small intestine,…”
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Altered Innate Defenses in the Neonatal Gastrointestinal Tract in Response to Colonization by Neuropathogenic Escherichia coli by Birchenough, George M H, Johansson, Malin E V, Stabler, Richard A, Dalgakiran, Fatma, Hansson, Gunnar C, Wren, Brendan W, Luzio, J Paul, Taylor, Peter W

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