Search Results - "George, Sven"

Synthesis and In Vitro Biological Evaluation of p -Carborane-Based Di- tert -butylphenol Analogs by Braun, Sebastian, Jelača, Sanja, Laube, Markus, George, Sven, Hofmann, Bettina, Lönnecke, Peter, Steinhilber, Dieter, Pietzsch, Jens, Mijatović, Sanja, Maksimović-Ivanić, Danijela, Hey-Hawkins, Evamarie

“…Targeting inflammatory mediators and related signaling pathways may offer a rational strategy for the treatment of cancer. The incorporation of metabolically…”
Get full text

Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids by Hellmuth, Nadine, Brat, Camilla, Awad, Omar, George, Sven, Kahnt, Astrid, Bauer, Tom, Huynh Phuoc, Hai Phong, Steinhilber, Dieter, Angioni, Carlo, Hassan, Mohamed, Hock, Katharina J., Manolikakes, Georg, Zacharowski, Kai, Roos, Jessica, Maier, Thorsten J.

“…Endogenous nitro-fatty acids (NFA) are potent electrophilic lipid mediators that exert biological effects in vitro and in vivo via selective covalent…”
Get full text

Novel and Potent Inhibitors of 5-Lipoxygenase Product Synthesis Based on the Structure of Pirinixic Acid by Werz, Oliver, Greiner, Christine, Koeberle, Andreas, Hoernig, Christina, George, Sven, Popescu, Laura, Syha, Ivonne, Schubert-Zsilavecz, Manfred, Steinhilber, Dieter

“…A novel class of potent 5-lipoxygenase (5-LO) product synthesis inhibitors based on the structure of pirinixic acid…”
Get full text

3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells by Poeckel, Daniel, Tausch, Lars, George, Sven, Jauch, Johann, Werz, Oliver

“…Previously, we showed that 11-keto-boswellic acid and 3-O-acetyl-11-keto-BA (AKBA) stimulate Ca(2+) mobilization and activate mitogen-activated protein kinases…”
Get more information

On the biosynthesis of specialized pro-resolving mediators in human neutrophils and the influence of cell integrity by Mainka, Malwina, George, Sven, Angioni, Carlo, Ebert, Roland, Goebel, Tamara, Kampschulte, Nadja, Krommes, Andre, Weigert, Andreas, Thomas, Dominique, Schebb, Nils Helge, Steinhilber, Dieter, Kahnt, Astrid Stefanie

“…Neutrophils are key players in inflammation initiation and resolution. Little attention has been paid to the detailed biosynthesis of specialized pro-resolving…”
Get full text

Unlocking the potential: unveiling tyrphostins with Michael-reactive cyanoacrylate motif as promising inhibitors of human 5-lipoxygenase by Molitor, Maximilian, Menge, Amelie, Mandel, Sebastian, George, Sven, Müller, Susanne, Knapp, Stefan, Hofmann, Bettina, Steinhilber, Dieter, Häfner, Ann-Kathrin

“…Human 5-lipoxygenase (5-LO) is the key enzyme in the biosynthesis of leukotrienes, mediators of the innate immune system that also play an important role in…”
Get full text

Thiazole derivatives as dual inhibitors of deoxyribonuclease I and 5-lipoxygenase: A promising scaffold for the development of neuroprotective drugs by Marković, Ana, Živković, Aleksandra, Atanasova, Mariyana, Doytchinova, Irini, Hofmann, Bettina, George, Sven, Kretschmer, Simon, Rödl, Carmen, Steinhilber, Dieter, Stark, Holger, Šmelcerović, Andrija

“…A library of 43 thiazole derivatives, including 31 previously and 12 newly synthesized in the present study, was evaluated in vitro for their inhibitory…”
Get full text

Design, Synthesis, and Structure–Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5‑Lipoxygenase by Hiesinger, Kerstin, Kramer, Jan S, Beyer, Sandra, Eckes, Timon, Brunst, Steffen, Flauaus, Cathrin, Wittmann, Sandra K, Weizel, Lilia, Kaiser, Astrid, Kretschmer, Simon B. M, George, Sven, Angioni, Carlo, Heering, Jan, Geisslinger, Gerd, Schubert-Zsilavecz, Manfred, Schmidtko, Achim, Pogoryelov, Denys, Pfeilschifter, Josef, Hofmann, Bettina, Steinhilber, Dieter, Schwalm, Stephanie, Proschak, Ewgenij

“…Inhibition of multiple enzymes of the arachidonic acid cascade leads to synergistic anti-inflammatory effects. Merging of 5-lipoxygenase (5-LOX) and soluble…”
Get full text

Systematic Assessment of Fragment Identification for Multitarget Drug Design by Brunst, Steffen, Kramer, Jan S., Kilu, Whitney, Heering, Jan, Pollinger, Julius, Hiesinger, Kerstin, George, Sven, Steinhilber, Dieter, Merk, Daniel, Proschak, Ewgenij

“…Designed multitarget ligands are a popular approach to generating efficient and safe drugs, and fragment‐based strategies have been postulated as a versatile…”
Get full text

Repurposing of 8‐Hydroxyquinoline‐Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors by Gajic, Mihajlo, Knez, Damijan, Sosič, Izidor, Mravljak, Janez, Meden, Anže, Košak, Urban, Leitzbach, Luisa, George, Sven, Hofmann, Bettina, Zivkovic, Aleksandra, Steinhilber, Dieter, Stark, Holger, Gobec, Stanislav, Smelcerovic, Andrija, Anderluh, Marko

“…A library of 31 butyrylcholinesterase (BChE) and cathepsin B (CatB) inhibitors was screened in vitro for inhibition of deoxyribonuclease I (DNase I). Compounds…”
Get full text

Carborane‐Based Tebufelone Analogs and Their Biological Evaluation In Vitro by Braun, Sebastian, Paskaš, Svetlana, Laube, Markus, George, Sven, Hofmann, Bettina, Lönnecke, Peter, Steinhilber, Dieter, Pietzsch, Jens, Mijatović, Sanja, Maksimović‐Ivanić, Danijela, Hey‐Hawkins, Evamarie

“…The presence of inflammatory mediators in the tumor microenvironment, such as cytokines, growth factors or eicosanoids, indicate cancer‐related inflammatory…”
Get full text

Borcalein: a Carborane‐Based Analogue of Baicalein with 12‐Lipoxygenase‐Independent Toxicity by Kuhnert, Robert, Kuhnert, Lydia, Sárosi, Menyhárt‐B., George, Sven, Draca, Dijana, Paskas, Svetlana, Hofmann, Bettina, Steinhilber, Dieter, Honscha, Walther, Mijatović, Sanja, Maksimović‐Ivanić, Danijela, Hey‐Hawkins, Evamarie

“…12‐Lipoxygenase is crucial for tumour angiogenesis. 5,6,7‐Trihydroxy‐2‐phenyl‐4H‐1‐benzopyran‐4‐one (baicalein) is a suitable inhibitor for this enzyme but is…”
Get full text

Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP by Häfner, Ann-Kathrin, Gerstmeier, Jana, Hörnig, Michael, George, Sven, Ball, Ann-Katrin, Schröder, Mirjam, Garscha, Ulrike, Werz, Oliver, Steinhilber, Dieter

“…Human 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes (LTs), important mediators of inflammation. Cellular 5-LO activity is regulated…”
Get full text

In Vitro Cytostatic Effect on Tumor Cells by Carborane‐Based Dual Cyclooxygenase‐2 and 5‐Lipoxygenase Inhibitors (Adv. Therap. 4/2023) by Braun, Sebastian, Paskas, Svetlana, Laube, Markus, George, Sven, Hofmann, Bettina, Lönnecke, Peter, Steinhilber, Dieter, Pietzsch, Jens, Mijatović, Sanja S., Maksimović‐Ivanić, Danijela, Hey‐Hawkins, Evamarie

“…Cyclooxygenase‐2 (COX‐2) and 5‐lipoxygenase (5‐LO) are key enzymes in the biosynthesis of pro‐inflammatory and tumor‐inducing eicosanoids. Thus, dual…”
Get full text

In Vitro Cytostatic Effect on Tumor Cells by Carborane‐Based Dual Cyclooxygenase‐2 and 5‐Lipoxygenase Inhibitors by Braun, Sebastian, Paskas, Svetlana, Laube, Markus, George, Sven, Hofmann, Bettina, Lönnecke, Peter, Steinhilber, Dieter, Pietzsch, Jens, Mijatović, Sanja S., Maksimović‐Ivanić, Danijela, Hey‐Hawkins, Evamarie

“…The selective inhibition of enzymes that catalyze the conversion of arachidonic acid to inflammatory eicosanoids represents a promising approach for cancer…”
Get full text

Carborane‐Based Analogues of 5‐Lipoxygenase Inhibitors Co‐inhibit Heat Shock Protein 90 in HCT116 Cells by Kuhnert, Robert, Sárosi, Menyhárt‐Botond, George, Sven, Lönnecke, Peter, Hofmann, Bettina, Steinhilber, Dieter, Steinmann, Sara, Schneider‐Stock, Regine, Murganić, Blagoje, Mijatović, Sanja, Maksimović‐Ivanić, Danijela, Hey‐Hawkins, Evamarie

“…5‐Lipoxygenase converts arachidonic acid into leukotrienes, which are involved in inflammation and angiogenesis. The introduction of carboranes can improve the…”
Get full text

CarbORev‐5901: The First Carborane‐Based Inhibitor of the 5‐Lipoxygenase Pathway by Kuhnert, Robert, Sárosi, Menyhárt‐Botond, George, Sven, Lönnecke, Peter, Hofmann, Bettina, Steinhilber, Dieter, Murganic, Blagoje, Mijatovic, Sanja, Maksimovic‐Ivanic, Danijela, Hey‐Hawkins, Evamarie

“…The progression of cancer is accelerated by increased proliferation, angiogenesis, and inflammation. These processes are mediated by leukotrienes. Several…”
Get full text

Synthesis and Structure–Activity Relationship Studies of Novel Dual Inhibitors of Soluble Epoxide Hydrolase and 5‑Lipoxygenase by Meirer, Karin, Rödl, Carmen B, Wisniewska, Joanna M, George, Sven, Häfner, Ann-Kathrin, Buscató, Estel·la, Klingler, Franca-Maria, Hahn, Steffen, Berressem, Dirk, Wittmann, Sandra K, Steinhilber, Dieter, Hofmann, Bettina, Proschak, Ewgenij

“…Current research leads to the assumption that drugs affecting more than one target could result in a more efficient treatment of diseases and fewer safety…”
Get full text

Design and Synthesis of Novel 2-Amino-5-hydroxyindole Derivatives That Inhibit Human 5-Lipoxygenase by Landwehr, Jens, George, Sven, Karg, Eva-Maria, Poeckel, Daniel, Steinhilber, Dieter, Troschuetz, Reinhard, Werz, Oliver

“…Compounds that inhibit 5-lipoxygenase (5-LO), the key enzyme in the biosynthesis of leukotrienes (LTs), possess potential for the treatment of inflammatory and…”
Get full text

Identification of Natural-Product-Derived Inhibitors of 5-Lipoxygenase Activity by Ligand-Based Virtual Screening by Franke, Lutz, Schwarz, Oliver, Müller-Kuhrt, Lutz, Hoernig, Christina, Fischer, Lutz, George, Sven, Tanrikulu, Yusuf, Schneider, Petra, Werz, Oliver, Steinhilber, Dieter, Schneider, Gisbert

“…A natural product collection and natural-product-derived combinatorial libraries were virtually screened for potential inhibitors of human 5-lipoxygenase…”
Get full text