Search Results - "George, Susan. R."

Heteromeric Dopamine Receptor Signaling Complexes: Emerging Neurobiology and Disease Relevance by PERREAULT, Melissa L, HASBI, Ahmed, O'DOWD, Brian F, GEORGE, Susan R

“…The pharmacological modification of dopamine transmission has long been employed as a therapeutic tool in the treatment of many mental health disorders…”
Get full text

Dopamine D1-D2 receptor heteromer expression in key brain regions of rat and higher species: Upregulation in rat striatum after cocaine administration by Hasbi, Ahmed, Sivasubramanian, Meenalochani, Milenkovic, Marija, Komarek, Kristina, Madras, Bertha K., George, Susan R.

“…Dopamine receptors interact with other receptors to form heterooligomers. One such complex, the D1-D2 heteromer, demonstrated in cultured striatal neurons and…”
Get full text

Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review by Hasbi, Ahmed, Madras, Bertha K, George, Susan R

“…There is a growing liberalization of cannabis-based preparations for medical and recreational use. In multiple instances, anxiety and depression are cited as…”
Get full text

Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth by Hasbi, Ahmed, Fan, Theresa, Alijaniaram, Mohammad, Nguyen, Tuan, Perreault, Melissa L, O'Dowd, Brian F, George, Susan R

“…Although the perturbation of either the dopaminergic system or brain-derived neurotrophic factor (BDNF) levels has been linked to important neurological and…”
Get full text

Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders by Williams, Olivia O. F., Coppolino, Madeleine, George, Susan R., Perreault, Melissa L.

“…Dopamine is an important neurotransmitter that plays a key role in neuropsychiatric illness. Sex differences in dopaminergic signaling have been acknowledged…”
Get full text

D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum by Rashid, Asim J, So, Christopher H, Kong, Michael M.C, Furtak, Teresa, El-Ghundi, Mufida, Cheng, Regina, O'Dowd, Brian F, George, Susan R

“…We demonstrate a heteromeric D1-D2 dopamine receptor signaling complex in brain that is coupled to Gq/11 and requires agonist binding to both receptors for G…”
Get full text

Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors by Hasbi, Ahmed, Nguyen, Tuan, Rahal, Haneen, Manduca, Joshua D, Miksys, Sharon, Tyndale, Rachel F, Madras, Bertha K, Perreault, Melissa L, George, Susan R

“…Depression and anxiety are more common among females than males and represent a leading cause of disease-related disability in women. Since the dopamine D1-D2…”
Get full text

Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance by Hasbi, Ahmed, O'Dowd, Brian F, George, Susan R

“…Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as…”
Get full text

G-Protein-coupled receptor oligomerization and its potential for drug discovery by George, Susan R, O'Dowd, Brian F, Lee, Samuel P

“…G-protein-coupled receptors (GPCRs) represent by far the largest class of targets for modern drugs. Virtually all therapeutics that are directed towards GPCRs…”
Get full text

Building a new conceptual framework for receptor heteromers by Ferré, Sergi, Baler, Ruben, Bouvier, Michel, Caron, Marc G, Devi, Lakshmi A, Durroux, Thierry, Fuxe, Kjell, George, Susan R, Javitch, Jonathan A, Lohse, Martin J, Mackie, Ken, Milligan, Graeme, Pfleger, Kevin D G, Pin, Jean-Philippe, Volkow, Nora D, Waldhoer, Maria, Woods, Amina S, Franco, Rafael

“…Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this…”
Get full text

Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2 by Perreault, Melissa L, Fan, Theresa, Alijaniaram, Mohammed, O'Dowd, Brian F, George, Susan R

“…In basal ganglia a significant subset of GABAergic medium spiny neurons (MSNs) coexpress D1 and D2 receptors (D1R and D2R) along with the neuropeptides…”
Get full text

Prevalence of hypocalcaemia and its associated features in 22q11·2 deletion syndrome by Cheung, Evelyn Ning Man, George, Susan R., Costain, Gary A., Andrade, Danielle M., Chow, Eva W. C., Silversides, Candice K., Bassett, Anne S.

“…Summary Background 22q11·2 deletion syndrome (22q11·2DS) is a relatively common yet under‐recognized genetic syndrome that may present with endocrine features…”
Get full text

Disparate Effects of Lithium and a GSK-3 Inhibitor on Neuronal Oscillatory Activity in Prefrontal Cortex and Hippocampus by Nguyen, Tuan, Fan, Theresa, George, Susan R, Perreault, Melissa L

“…Glycogen synthase kinase-3 (GSK-3) plays a critical role in cognitive dysfunction associated with Alzheimer's disease (AD), yet the mechanism by which GSK-3…”
Get full text

Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB by Hasbi, Ahmed, Perreault, Melissa L, Shen, Maurice Y F, Fan, Theresa, Nguyen, Tuan, Alijaniaram, Mohammed, Banasikowski, Tomek J, Grace, Anthony A, O'Dowd, Brian F, Fletcher, Paul J, George, Susan R

“…A significant subpopulation of neurons in rat nucleus accumbens (NAc) coexpress dopamine D1 and D2 receptors, which can form a D1-D2 receptor complex, but…”
Get full text

Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal by Grieder, Taryn E, George, Olivier, Tan, Huibing, George, Susan R, Le Foll, Bernard, Laviolette, Steven R, van der Kooy, Derek

“…Nicotine, the main psychoactive ingredient of tobacco smoke, induces negative motivational symptoms during withdrawal that contribute to relapse in dependent…”
Get full text

Dopamine D1 and D2 Receptor Co-activation Generates a Novel Phospholipase C-mediated Calcium Signal by Lee, Samuel P, So, Christopher H, Rashid, Asim J, Varghese, George, Cheng, Regina, Lança, A José, O'Dowd, Brian F, George, Susan R

“…Although dopamine D1 and D2 receptors belong to distinct subfamilies of dopamine receptors, several lines of evidence indicate that they are functionally…”
Get full text

The dopamine d1-d2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in Basal Ganglia by Perreault, Melissa L, Hasbi, Ahmed, O'Dowd, Brian F, George, Susan R

“…Dopaminergic signaling within the basal ganglia has classically been thought to occur within two distinct neuronal pathways; the direct striatonigral pathway…”
Get full text

Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers by So, Christopher H, Verma, Vaneeta, Alijaniaram, Mohammad, Cheng, Regina, Rashid, Asim J, O'Dowd, Brian F, George, Susan R

“…In this report, we investigated whether the D5 dopamine receptor, given its structural and sequence homology with the D1 receptor, could interact with the D2…”
Get more information

Modification of the Terminal Residue of Apelin-13 Antagonizes Its Hypotensive Action by Lee, Dennis K, Saldivia, Victor R, Nguyen, Tuan, Cheng, Regina, George, Susan R, O’Dowd, Brian F

“…The apelin peptide is the endogenous ligand for the apelin G protein-coupled receptor. The distribution of the apelin peptides and receptor are widespread in…”
Get full text

A systematic review examining the effects of therapeutic radioactive iodine on ovarian function and future pregnancy in female thyroid cancer survivors by Sawka, Anna M., Lakra, Deepak C., Lea, Jane, Alshehri, Bandar, Tsang, Richard W., Brierley, James D., Straus, Sharon, Thabane, Lehana, Gafni, Amiram, Ezzat, Shereen, George, Susan R., Goldstein, David P.

“…Summary Background  For women with differentiated thyroid carcinoma (DTC), the effect of radioactive iodine (RAI) therapy on gonadal and reproductive function…”
Get full text