Search Results - "George, Sophie A."

Single Prolonged Stress Disrupts Retention of Extinguished Fear in Rats by Knox, Dayan, George, Sophie A, Fitzpatrick, Christopher J, Rabinak, Christine A, Maren, Stephen, Liberzon, Israel

“…Clinical research has linked post-traumatic stress disorder (PTSD) with deficits in fear extinction. However, it is not clear whether these deficits result…”
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Sleep alterations following exposure to stress predict fear-associated memory impairments in a rodent model of PTSD by Vanderheyden, William M., George, Sophie A., Urpa, Lea, Kehoe, Michaela, Liberzon, Israel, Poe, Gina R.

“…Sleep abnormalities, such as insomnia, nightmares, hyper-arousal, and difficulty initiating or maintaining sleep, are diagnostic criteria of posttraumatic…”
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CRH-stimulated cortisol release and food intake in healthy, non-obese adults by George, Sophie A, Khan, Samir, Briggs, Hedieh, Abelson, James L

“…Summary Background There is considerable anecdotal and some scientific evidence that stress triggers eating behavior, but underlying physiological mechanisms…”
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Maternal Separation Induces Sex-Specific Differences in Sensitivity to Traumatic Stress by Knox, Dayan, Stout-Oswald, Stephanie A, Tan, Melissa, George, Sophie A, Liberzon, Israel

“…Post-traumatic stress disorder (PTSD) is a debilitating psychiatric disorder with a high economic burden. Two risk factors for increasing the chances of…”
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Altered locus coeruleus-norepinephrine function following single prolonged stress by George, Sophie A., Knox, Dayan, Curtis, Andre L., Aldridge, J. Wayne, Valentino, Rita J., Liberzon, Israel

“…Data from preclinical and clinical studies have implicated the norepinephrine system in the development and maintenance of post‐traumatic stress disorder. The…”
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Prospective measurement of skin conductance response during trauma interview predicts future PTSD severity in trauma exposed children by Basarkod, Sattvik, Valbrun, Shaurel, Wiltshire, Charis, France, John McClellan, Davie, William, Winters, Sterling, George, Sophie A., Stenson, Anais F., Jovanovic, Tanja

“…Previous cross-sectional studies have shown that sympathetic nervous system (SNS) arousal is positively associated with posttraumatic stress disorder (PTSD)…”
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Diminished Value Discrimination in Obsessive-Compulsive Disorder: A Prospect Theory Model of Decision-Making Under Risk by George, Sophie A, Sheynin, Jony, Gonzalez, Richard, Liberzon, Israel, Abelson, James L

“…It has been hypothesized that people diagnosed with anxiety and obsessive-compulsive disorder (OCD) exhibit behavioral aberrations when faced with the…”
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Research With Refugees and Vulnerable Populations in a Post-COVID World: Challenges and Opportunities by Saad, Bassem, George, Sophie A., Bazzi, Celine, Gorski, Kathleen, Abou-Rass, Noor, Shoukfeh, Rajaa, Javanbakht, Arash

“…At the Stress, Trauma and Anxiety Research Clinic (STARC) at Wayne State University in Detroit, we are currently amid data collection for a longitudinal…”
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The effect of chronic phenytoin administration on single prolonged stress induced extinction retention deficits and glucocorticoid upregulation in the rat medial prefrontal cortex by George, Sophie A., Rodriguez-Santiago, Mariana, Riley, John, Rodriguez, Elizabeth, Liberzon, Israel

“…Rationale Post-traumatic stress disorder (PTSD) is a chronic, debilitating disorder. Only two pharmacological agents are approved for PTSD treatment, and they…”
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Alterations in cognitive flexibility in a rat model of post-traumatic stress disorder by George, Sophie A., Rodriguez-Santiago, Mariana, Riley, John, Abelson, James L., Floresco, Stan B., Liberzon, Israel

“…•Single prolonged stress (SPS) leads to complex alterations in flexible responding.•SPS did not impair acquisition of either a response or visual-cue…”
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Severe, multimodal stress exposure induces PTSD-like characteristics in a mouse model of single prolonged stress by Perrine, Shane A., Eagle, Andrew L., George, Sophie A., Mulo, Kostika, Kohler, Robert J., Gerard, Justin, Harutyunyan, Arman, Hool, Steven M., Susick, Laura L., Schneider, Brandy L., Ghoddoussi, Farhad, Galloway, Matthew P., Liberzon, Israel, Conti, Alana C.

“…•Development of a mouse single prolonged stress (mSPS) model of PTSD.•Exposure to mSPS enhanced cue-induced fear, which was attenuated by paroxetine.•mSPS…”
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Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex by Knox, Dayan, Perrine, Shane A., George, Sophie A., Galloway, Matthew P., Liberzon, Israel

“…Application of single prolonged stress (SPS) in rats induces changes in neuroendocrine function and arousal that are characteristic of post traumatic stress…”
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D-Cycloserine Facilitates Reversal in an Animal Model of Post-traumatic Stress Disorder by George, Sophie A., Rodriguez-Santiago, Mariana, Riley, John, Abelson, James L., Floresco, Stan B., Liberzon, Israel

“…•DCS had a beneficial effect on response discrimination reversal in SPS rats.•Error-type analysis indicated DCS helped to maintain accurate responding.•DCS was…”
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SSRI-Enhanced Locus Coeruleus Activity and Adolescent Suicide: Lessons from Animal Models by Liberzon, Israel, George, Sophie A

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Unconditioned freezing is enhanced in an appetitive context: Implications for the contextual dependency of unconditioned fear by Knox, Dayan, Fitzpatrick, Christopher J., George, Sophie A., Abelson, James L., Liberzon, Israel

“…► Unconditioned fear is enhanced in an appetitive context. ► This enhancement suggests unconditioned fear is sensitive to contextual modulation. ► This…”
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Early handling attenuates enhancement of glucocorticoid receptors in the prefrontal cortex in an animal model of post-traumatic stress disorder by George, Sophie A, Stout, Stephanie A, Tan, Melissa, Knox, Dayan, Liberzon, Israel

“…Changes in glucocorticoid receptors (GRs) have been implicated in the pathogenesis of stress related psychiatric disorders such as depression and…”
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