Search Results - "George, R."
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The JAK-STAT Pathway at Twenty
Published in Immunity (Cambridge, Mass.) (20-04-2012)“…We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular…”
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Targeting the Hepatocyte Growth Factor–cMET Axis in Cancer Therapy
Published in Journal of clinical oncology (10-09-2012)“…The hepatocyte growth factor (HGF) and its receptor, the transmembrane tyrosine kinase cMET, promote cell proliferation, survival, motility, and invasion as…”
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The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin
Published in Drugs (New York, N.Y.) (01-10-2021)“…The epidemiology of invasive fungal infections is changing, with new populations at risk and the emergence of resistance caused by the selective pressure from…”
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4
Programmed Death-Ligand 1 Heterogeneity and Its Impact on Benefit From Immune Checkpoint Inhibitors in NSCLC
Published in Journal of thoracic oncology (01-09-2020)“…Programmed death-ligand 1 (PD-L1) expression may vary in different disease sites and at different time points of the disease course. We aimed to investigate…”
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5
Aspergillosis: Epidemiology, Diagnosis, and Treatment
Published in Infectious disease clinics of North America (01-06-2021)“…The spectrum of disease produced by Aspergillus species ranges from allergic syndromes to chronic pulmonary conditions and invasive infections. Invasive…”
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6
P2X7 receptor regulation of non‐classical secretion from immune effector cells
Published in Cellular microbiology (01-11-2012)“…Summary P2X7 receptors (P2X7R) are extracellular ATP‐gated ion channels expressed in the immune effector cells that carry out critical protective responses…”
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50th Anniversary Perspective: Functional Nanoparticles from the Solution Self-Assembly of Block Copolymers
Published in Macromolecules (09-05-2017)“…This Perspective outlines recent advances concerning the formation and potential uses of block copolymer micelles, a class of soft-matter-based nanoparticles…”
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Aspiring Antifungals: Review of Current Antifungal Pipeline Developments
Published in Journal of fungi (Basel) (01-03-2020)“…Invasive fungal infections are associated with significant morbidity and mortality, and their management is restricted to a variety of agents from five…”
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Advances in high-speed atomic force microscopy (HS-AFM) reveal dynamics of transmembrane channels and transporters
Published in Current opinion in structural biology (01-08-2019)“…•HS-AFM detects conformational changes of unlabeled membrane proteins.•In situ responses to pH, ligands, temperature and light can be visualized.•Developments…”
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10
Canonical Microcircuits for Predictive Coding
Published in Neuron (Cambridge, Mass.) (21-11-2012)“…This Perspective considers the influential notion of a canonical (cortical) microcircuit in light of recent theories about neuronal processing. Specifically,…”
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11
Evidence for antibody as a protective correlate for COVID-19 vaccines
Published in Vaccine (22-07-2021)“…A correlate of protection (CoP) is urgently needed to expedite development of additional COVID-19 vaccines to meet unprecedented global demand. To assess…”
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12
Wildfire smoke, a potential infectious agent
Published in Science (American Association for the Advancement of Science) (18-12-2020)“…Bacteria and fungi are transported in wildland fire smoke emissions Wildfires over the past 3 years have resulted in lengthy episodes of smoke inundation…”
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13
Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
Published in Nature communications (15-02-2016)“…Although extracellular ATP is abundant at sites of inflammation, its role in activating inflammasome signalling in neutrophils is not well characterized. In…”
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14
Exciting red and competent blue: the importance of color in marketing
Published in Journal of the Academy of Marketing Science (01-09-2012)“…From beverages to consumer electronics, marketers are using color in innovative ways. Despite this, little academic research has investigated the role that…”
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15
Aspergillus Infections
Published in The New England journal of medicine (14-10-2021)“…Aspergillosis is an opportunistic fungal infection that poses a particular risk for patients with neutrophil defects and causes diverse clinical syndromes…”
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16
High-speed AFM height spectroscopy reveals µs-dynamics of unlabeled biomolecules
Published in Nature communications (26-11-2018)“…Dynamics are fundamental to the functions of biomolecules and can occur on a wide range of time and length scales. Here we develop and apply high-speed AFM…”
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Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America
Published in Clinical infectious diseases (15-08-2016)“…It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment…”
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Coccidioidomycosis
Published in Infectious disease clinics of North America (01-03-2016)“…Coccidioides immitis and C posadasii are pathogenic dimorphic fungi responsible for causing coccidioidomycosis in the Southwestern United States and Central…”
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19
HIV latency is reversed by ACSS2-driven histone crotonylation
Published in The Journal of clinical investigation (01-03-2018)“…Eradication of HIV-1 (HIV) is hindered by stable viral reservoirs. Viral latency is epigenetically regulated. While the effects of histone acetylation and…”
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Long-range exciton transport in conjugated polymer nanofibers prepared by seeded growth
Published in Science (American Association for the Advancement of Science) (25-05-2018)“…Easily processed materials with the ability to transport excitons over length scales of more than 100 nanometers are highly desirable for a range of…”
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