Role of curcumin on chloroquine phosphate-induced reproductive toxicity

The present study was conducted to screen the efficacy of curcumin against chloroquine phosphate (CQ)-induced reproductive toxicity in adult male Swiss albino mice. Animals were given oral doses of 100, 200, 300 mg/kg body weight (b.w.), and high dose of CQ (300 mg/kg b.w.) + curcumin (80 mg/kg b.w....

Full description

Saved in:

Bibliographic Details
Published in:	Drug and chemical toxicology (New York, N.Y. 1978) Vol. 35; no. 2; pp. 184 - 191
Main Authors:	Desai, Ketaki R., Dattani, Jignasa J., Rajput, Dhrupad K., Moid, Nilofar, Highland, Hyacinth N., George, Linzbuoy B.
Format:	Journal Article
Language:	English
Published:	United States Informa Healthcare 01-04-2012 Taylor & Francis
Subjects:	Acid Phosphatase - metabolism Adenosine Triphosphatases - metabolism Alkaline Phosphatase - metabolism Animals Antimalarials - toxicity Chloroquine - analogs & derivatives Chloroquine - toxicity Chloroquine phosphate curcumin Curcumin - pharmacology Dose-Response Relationship, Drug Drug Interactions Enzyme Inhibitors - pharmacology Male Mice oxidative stress Random Allocation reproductive toxicity Succinate Dehydrogenase - metabolism Superoxide Dismutase - metabolism Testis - drug effects Testis - metabolism Thiobarbituric Acid Reactive Substances - metabolism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The present study was conducted to screen the efficacy of curcumin against chloroquine phosphate (CQ)-induced reproductive toxicity in adult male Swiss albino mice. Animals were given oral doses of 100, 200, 300 mg/kg body weight (b.w.), and high dose of CQ (300 mg/kg b.w.) + curcumin (80 mg/kg b.w.) for 45 days. Animals of the withdrawal group were given high dose of CQ (300 mg/kg b.w.) for 45 days and, at day 46, were kept for another 45 days. Effects were observed on some key enzymes, such as alkaline phosphatase, which was found to be decreased, whereas acid phosphatase was increased and succinate dehydrogenase and adenosine triphosphatase were decreased. Oxidative parameters, such as superoxide dismutase declined, whereas thiobarbituric acid-reactive substances were found to be elevated. Protein level was also decreased. Gravimetric indices were also recorded. Results obtained indicated adverse effects of CQ in a dose-dependent manner. The presence of curcumin with CQ alleviated its toxic effects. Hence, it can be concluded that curcumin has beneficial influences and appears able to ameliorate CQ toxicity.
ISSN:	0148-0545 1525-6014
DOI:	10.3109/01480545.2011.589846