Search Results - "George, Kristen M"
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Lifecourse socioeconomic changes and late-life cognition in a cohort of U.S.-born and U.S. immigrants: findings from the KHANDLE study
Published in BMC public health (13-05-2021)“…Low socioeconomic status (SES) in early and late life has been associated with lower late-life cognition. Less is known about how changes in SES from childhood…”
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AD and non‐AD mediators of the pathway between the APOE genotype and cognition
Published in Alzheimer's & dementia (01-06-2023)“…Introduction The apolipoprotein E (APOE) genotype is a driver of cognitive decline and dementia. We used causal mediation methods to characterize pathways…”
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Evaluating interpersonal discrimination and depressive symptoms as partial mediators of the effects of education on cognition: Evidence from the Study of Healthy Aging in African Americans (STAR)
Published in Alzheimer's & dementia (01-07-2023)“…Introduction Education is correlated with positive health outcomes, but associations are sometimes weaker among African Americans. The extent to which exposure…”
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What is the association between adverse childhood experiences and late-life cognitive decline? Study of Healthy Aging in African Americans (STAR) cohort study
Published in BMJ open (02-11-2023)“…ObjectivesAdverse childhood experiences (ACEs) are associated with higher risk of chronic disease, but little is known about the association with late life…”
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Association Between Thyroid Dysfunction and Incident Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study
Published in Journal of endocrinology and metabolism (01-08-2019)“…Abnormal thyroid hormone levels (high or low) and autoimmunity from autoimmune thyroid disease (AITD) may increase dementia risk. We examined the associations…”
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Association of Carotid Intima-Media Thickness and Other Carotid Ultrasound Features With Incident Dementia in the ARIC-NCS
Published in Journal of the American Heart Association (04-05-2021)“…Background Increased carotid intima-media thickness, interadventitial diameter, presence of carotid plaque, and lower distensibility are predictors for…”
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Neighborhood socioeconomic status and segregation linked to cognitive decline
Published in Alzheimer's & dementia : diagnosis, assessment & disease monitoring (01-01-2023)“…Introduction Few longitudinal studies have examined the joint impact of neighborhood segregation and neighborhood socioeconomic status (NSES) in cognitive…”
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Response to “proportion of life spent in Canada and stroke incidence and outcomes in immigrants”
Published in Annals of epidemiology (01-03-2023)Get full text
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Rural residence across the life course and late‐life cognitive decline in KHANDLE: A causal inference study
Published in Alzheimer's & dementia : diagnosis, assessment & disease monitoring (01-01-2023)“…Background Modifiable risks for dementia are more prevalent in rural populations, yet there is a dearth of research examining life course rural residence on…”
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Evaluation of racial and ethnic heterogeneity in the associations of sleep quality and sleep apnea risk with cognitive function and cognitive decline
Published in Alzheimer's & dementia : translational research & clinical interventions (01-01-2024)“…INTRODUCTION The prevalence of poor sleep quality and sleep apnea differs by race and ethnicity and may contribute to racial disparities in cognitive aging. We…”
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Differences in association of leisure time activities and cognition in a racially/ethnically diverse cohort of older adults: Findings from the KHANDLE study
Published in Alzheimer's & dementia : translational research & clinical interventions (2020)“…Introduction Leisure time activity is associated with better cognitive function but has not been well studied in racially/ethnically diverse cohorts, who may…”
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Magnetic resonance imaging of the cervical spinal cord in multiple sclerosis at 7T
Published in Multiple sclerosis (01-03-2016)“…Background: The clinical course of multiple sclerosis (MS) is mainly attributable to cervical and upper thoracic spinal cord dysfunction. High-resolution, 7T…”
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Life-Course Individual and Neighborhood Socioeconomic Status and Risk of Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study
Published in American journal of epidemiology (01-10-2020)“…Abstract We examined associations of individual- and neighborhood-level life-course (LC) socioeconomic status (SES) with incident dementia in the…”
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Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline
Published in Brain (London, England : 1878) (27-08-2022)“…Accumulating data suggest that cerebrovascular disease contributes to Alzheimer's disease pathophysiology and progression toward dementia. Cerebral amyloid…”
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Sex-specific effects of microglial activation on Alzheimer's disease proteinopathy in older adults
Published in Brain (London, England : 1878) (21-10-2022)“…Females show a disproportionate burden of Alzheimer's disease pathology and higher Alzheimer's disease dementia prevalences compared to males, yet the…”
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Impact of Cardiovascular Risk Factors in Adolescence, Young Adulthood, and Midlife on Late-Life Cognition: Study of Healthy Aging in African Americans
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01-09-2021)“…Midlife cardiovascular risk factors (CVRFs) increase risk of dementia. Black Americans experience an elevated prevalence of CVRFs and dementia. However, little…”
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The structural and social determinants of Alzheimer's disease related dementias
Published in Alzheimer's & dementia (01-07-2023)“…Introduction The projected growth of Alzheimer's disease (AD) and AD‐related dementia (ADRD) cases by midcentury has expanded the research field and impelled…”
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Education and Cardiovascular Health as Effect Modifiers of APOE ε4 on Dementia: The Atherosclerosis Risk in Communities Study
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01-06-2022)“…Abstract Background Both education and cardiovascular risk factors are strongly associated with dementia risk. However, it is not clear whether these…”
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School racial/ethnic composition, effect modification by caring teacher/staff presence, and mid-/late-life depressive symptoms: findings from the Study of Healthy Aging in African Americans
Published in American journal of epidemiology (03-09-2024)“…Abstract For Black students in the United States, attending schools with a higher proportion of White students is associated with worse mental and physical…”
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Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study
Published in Neurology (31-10-2023)“…Studies on the association between proton pump inhibitor (PPI) use and dementia report mixed results and do not examine the impact of cumulative PPI use. We…”
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