Search Results - "George, Judith A."

Accelerated structural decrements in the aging female rhesus macaque lung compared with males by Herring, Matt J, Avdalovic, Mark V, Quesenberry, Cheryl L, Putney, Lei F, Tyler, Nancy K, Ventimiglia, Frank F, St George, Judith A, Hyde, Dallas M

“…Aging is associated with morphometric changes in the lung that lead to decreased lung function. The nonhuman primate lung has been shown to have similar…”
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Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease by Hirsh, Andrew J, Zhang, Jim, Zamurs, Andra, Fleegle, Jacquelyn, Thelin, William R, Caldwell, Ray A, Sabater, Juan R, Abraham, William M, Donowitz, Mark, Cha, Boyoung, Johnson, Kevin B, St George, Judith A, Johnson, M Ross, Boucher, Richard C

“…Amiloride improves mucociliary clearance (MC) by blocking airway epithelial sodium channels (ENaC) and expanding airway surface liquid (ASL). However, the low…”
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Enhanced efficacy of melanoma vaccines in the absence of B lymphocytes by PERRICONE, Michael A, SMITH, Karen A, CLAUSSEN, Kirsten A, PLOG, Malinda S, HEMPEL, Donna M, ROBERTS, Bruce L, ST. GEORGE, Judith A, KAPLAN, Johanne M

“…Provoking a specific cellular immune response against tumor-associated antigens is a promising therapeutic strategy to treat cancers with defined antigens such…”
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Soluble Transforming Growth Factor-beta Type III Receptor Gene Transfection Inhibits Fibrous Airway Obliteration in a Rat Model of Bronchiolitis Obliterans by LIU, MINGYAO, SUGA, MICHIHARU, MACLEAN, ALEXANDRA A, ST. GEORGE, JUDITH A, SOUZA, DAVID W, KESHAVJEE, SHAF

“…Post-transplant bronchiolitis obliterans (BO) is characterized by fibroproliferation and fibrous obliteration of distal airways in chronically rejected lungs…”
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Preclinical safety and biodistribution of adenovirus-based cancer vaccines after intradermal delivery by Plog, Malinda S, Guyre, Cheryl A, Roberts, Bruce L, Goldberg, Mark, St George, Judith A, Perricone, Michael A

“…The recombinant adenoviral (Ad) vector is being considered as a cancer vaccine platform because it efficiently induces immune responses to tumor antigens by…”
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Characterization of an adenovirus gene transfer vector containing an E4 deletion by Armentano, D, Sookdeo, C C, Hehir, K M, Gregory, R J, St George, J A, Prince, G A, Wadsworth, S C, Smith, A E

“…We describe the construction and characterization of an adenovirus type 2 vector, Ad2E4ORF6, which has been modified in the E4 region to contain only open…”
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The plant pathogenesis related protein GLIPR-2 is highly expressed in fibrotic kidney and promotes epithelial to mesenchymal transition in vitro by Baxter, Ruth M., Crowell, Thomas P., George, Judith A., Getman, Michael E., Gardner, Humphrey

“…Fibrosis is the accumulation of extracellular matrix proteins and is a common end pathway in many chronic diseases. To identify novel mediators of fibrosis we…”
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Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. I. Methods, safety, and clinical implications by Joseph, P M, O'Sullivan, B P, Lapey, A, Dorkin, H, Oren, J, Balfour, R, Perricone, M A, Rosenberg, M, Wadsworth, S C, Smith, A E, St George, J A, Meeker, D P

“…Cystic fibrosis (CF), an autosomal recessive disorder resulting from mutations in the cystic fibrosis trans-membrane conductance regulator (CFTR) gene, is the…”
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Basis of pulmonary toxicity associated with cationic lipid-mediated gene transfer to the mammalian lung by Scheule, R K, St George, J A, Bagley, R G, Marshall, J, Kaplan, J M, Akita, G Y, Wang, K X, Lee, E R, Harris, D J, Jiang, C, Yew, N S, Smith, A E, Cheng, S H

“…Studies have indicated that although abundant levels of transgene expression could be achieved in the lungs of mice instilled with cationic lipid:pDNA…”
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Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. II. Transfection efficiency in airway epithelium by Perricone, M A, Morris, J E, Pavelka, K, Plog, M S, O'Sullivan, B P, Joseph, P M, Dorkin, H, Lapey, A, Balfour, R, Meeker, D P, Smith, A E, Wadsworth, S C, St George, J A

“…A phase I clinical trial was conducted in which recombinant adenovirus containing the cystic fibrosis trans-membrane regulator (CFTR) (Ad2/CFTR) was…”
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Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats by Zabner, Joseph, Petersen, Deanna M, Puga, Aurita P, Graham, Scott M, Couture, Larry A, Keyes, Lynn D, Lukason, Mike J, St. George, Judith A, Gregory, Richard J, Smith, Alan E, Welsh, Michael J

“…Gene therapy for cystic fibrosis (CF) will require the safe transfer of CFTR cDNA to airway epithelia in vivo. We showed previously that a recombinant…”
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Potentiation of gene transfer to the mouse lung by complexes of adenovirus vector and polycations improves therapeutic potential by Kaplan, J M, Pennington, S E, St George, J A, Woodworth, L A, Fasbender, A, Marshall, J, Cheng, S H, Wadsworth, S C, Gregory, R J, Smith, A E

“…Recombinant adenovirus (Ad) vectors are being considered for in vivo delivery of various therapeutic genes. One limiting factor in the development of Ad-based…”
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A concentrated and stable aerosol formulation of cationic lipid:DNA complexes giving high-level gene expression in mouse lung by Eastman, S J, Lukason, M J, Tousignant, J D, Murray, H, Lane, M D, St George, J A, Akita, G Y, Cherry, M, Cheng, S H, Scheule, R K

“…Advances in gene therapy vectors and techniques hold promise for treatment of many inherited and acquired diseases. For lung indications, especially those…”
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PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ by Sheppard, Kelly-Ann, Fitz, Lori J., Lee, Julie M., Benander, Christina, George, Judith A., Wooters, Joe, Qiu, Yongchang, Jussif, Jason M., Carter, Laura L., Wood, Clive R., Chaudhary, Divya

“…Engagement of the immunoinhibitory receptor, programmed death-1 (PD-1) attenuates T-cell receptor (TCR)-mediated activation of IL-2 production and T-cell…”
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Adenoviral Vector Expressing ICP47 Inhibits Adenovirus-Specific Cytotoxic T Lymphocytes in Nonhuman Primates by Scaria, Abraham, Sullivan, Jennifer A., St. George, Judith A., Kaplan, Johanne M., Lukason, Michael J., Morris, James E., Plog, Malinda, Nicolette, Charles, Gregory, Richard J., Wadsworth, Samuel C.

“…Studies from several laboratories have shown that administration of E1-deleted Ad vectors results only in transient transgene expression in the lungs of…”
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E4ORF3 Requirement for Achieving Long-Term Transgene Expression from the Cytomegalovirus Promoter in Adenovirus Vectors by Armentano, D, Smith, M P, Sookdeo, C C, Zabner, J, Perricone, M A, St George, J A, Wadsworth, S C, Gregory, R J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Adenovirus-Mediated Persistent Cystic Fibrosis Transmembrane Conductance Regulator Expression in Mouse Airway Epithelium by Scaria, A, St George, J A, Jiang, C, Kaplan, J M, Wadsworth, S C, Gregory, R J

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Safety of airway gene transfer with Ad2/CFTR2: aerosol administration in the nonhuman primate by McDonald, R J, Lukason, M J, Raabe, O G, Canfield, D R, Burr, E A, Kaplan, J M, Wadsworth, S C, St George, J A

“…In this study, the safety and efficacy of aerosol delivery to non-human primates of an adenoviral vector encoding the cystic fibrosis transmembrane conductance…”
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Increased contact time improves adenovirus-mediated CFTR gene transfer to nasal epithelium of CF mice by Jiang, C, Akita, G Y, Colledge, W H, Ratcliff, R A, Evans, M J, Hehir, K M, St George, J A, Wadsworth, S C, Cheng, S H

“…Multiple dosing with recombinant adenoviral vectors containing the cystic fibrosis transmembrane conductance regulator (CFTR) cDNA to the nasal mucosa of…”
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An ELISA method for the quantitation of tracheal mucins from human and nonhuman primates by Lin, H, Carlson, D M, St George, J A, Plopper, C G, Wu, R

“…Monoclonal antibodies, 17B1 and 17Q2, which are specific for large molecular weight mucous glycoproteins of airway epithelium, have been used to develop an…”
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