Search Results - "George, Christopher N."

Oestrogen and zoledronic acid driven changes to the bone and immune environments: Potential mechanisms underlying the differential anti-tumour effects of zoledronic acid in pre- and post-menopausal conditions by George, Christopher N., Canuas-Landero, Victor, Theodoulou, Elizavet, Muthana, Munitta, Wilson, Caroline, Ottewell, Penelope

“…•Zoledronic acid can prevent recurrence and improve survival when given in early breast cancer.•Anti-cancer effects were only observed in post-menopausal women…”
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Oestradiol Contributes to Differential Antitumour Effects of Adjuvant Zoledronic Acid Observed Between Pre- and Post-Menopausal Women by Canuas-Landero, Victor G, George, Christopher N, Lefley, Diane V, Corness, Hannah, Muthana, Munitta, Wilson, Caroline, Ottewell, Penelope D

“…Clinical trials have demonstrated that adding zoledronic acid (Zol) to (neo)adjuvant standard of care has differential antitumour effects in pre- and…”
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Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGFB signalling in vitro and in an OIM mouse model by Morita, Mai, Arshad, Fawaz, Quayle, Lewis A., George, Christopher N., Lefley, Diane V., Kalajzic, Ivo, Balsubramanian, Meena, Cebe, Tugba, Reilly, Gwen, Bishop, Nicolas J., Ottewell, Penelope D.

“…Excessive production of Transforming Growth Factor β (TGFβ) is commonly associated with dominant and recessive forms of OI. Previous reports have indicated…”
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Novel Methods of Targeting IL-1 Signalling for the Treatment of Breast Cancer Bone Metastasis by Zhou, Jiabao, Down, Jennifer M, George, Christopher N, Murphy, Jessica, Lefley, Diane V, Tulotta, Claudia, Alsharif, Marwa A, Leach, Michael, Ottewell, Penelope D

“…Breast cancer bone metastasis is currently incurable. Evidence suggests that inhibiting IL-1 signalling with the IL1R antagonist, Anakinra, or the IL1β…”
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Losartan alters osteoblast differentiation and increases bone mass through inhibition of TGF B signalling in vitro and in an OIM mouse model by Morita, Mai, Arshad, Fawaz, Quayle, Lewis A, George, Christopher N, Lefley, Diane V, Kalajzic, Ivo, Balsubramanian, Meena, Cebe, Tugba, Reilly, Gwen, Bishop, Nicolas J, Ottewell, Penelope D

“…Excessive production of Transforming Growth Factor β (TGFβ) is commonly associated with dominant and recessive forms of OI. Previous reports have indicated…”
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A hardware-driven profiling scheme for identifying program hot spots to support runtime optimization by Merten, Matthew C., Trick, Andrew R., George, Christopher N., Gyllenhaal, John C., Hwu, Wen-mei W.

“…This paper presents a novel hardware-based approach for identifying, profiling, and monitoring hot spots in order to support runtime optimization of general…”
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An architectural framework for runtime optimization by Merten, M.C., Trick, A.R., Barnes, R.D., Nystrom, E.M., George, C.N., Gyllenhaal, J.C., Hwu, W.-M.W.

“…Wide-issue processors continue to achieve higher performance by exploiting greater instruction-level parallelism. Dynamic techniques such as out-of-order…”
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Protecting IP in an agile software development environment by George, Christopher N, Millien, Raymond

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