Search Results - "George, Benson M"

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity by Gordon, Sydney R., Maute, Roy L., Dulken, Ben W., Hutter, Gregor, George, Benson M., McCracken, Melissa N., Gupta, Rohit, Tsai, Jonathan M., Sinha, Rahul, Corey, Daniel, Ring, Aaron M., Connolly, Andrew J., Weissman, Irving L.

“…Mouse and human tumour-associated macrophages express PD-1, which increases with cancer stage and induces decreased phagocytosis by macrophages; by contrast,…”
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Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma by Ji, Andrew L., Rubin, Adam J., Thrane, Kim, Jiang, Sizun, Reynolds, David L., Meyers, Robin M., Guo, Margaret G., George, Benson M., Mollbrink, Annelie, Bergenstråhle, Joseph, Larsson, Ludvig, Bai, Yunhao, Zhu, Bokai, Bhaduri, Aparna, Meyers, Jordan M., Rovira-Clavé, Xavier, Hollmig, S. Tyler, Aasi, Sumaira Z., Nolan, Garry P., Lundeberg, Joakim, Khavari, Paul A.

“…To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC), we combined single-cell RNA sequencing with spatial…”
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Is age just a number? Intensive therapy for core binding factor acute myeloid leukemia in older adults by George, Benson M., Luskin, Marlise R.

“…Not available.Not available…”
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Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy by Barkal, Amira A., Weiskopf, Kipp, Kao, Kevin S., Gordon, Sydney R., Rosental, Benyamin, Yiu, Ying Y., George, Benson M., Markovic, Maxim, Ring, Nan G., Tsai, Jonathan M., McKenna, Kelly M., Ho, Po Yi, Cheng, Robin Z., Chen, James Y., Barkal, Layla J., Ring, Aaron M., Weissman, Irving L., Maute, Roy L.

“…Exciting progress in the field of cancer immunotherapy has renewed the urgency of the need for basic studies of immunoregulation in both adaptive cell lineages…”
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Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types by Loh, Kyle M., Chen, Angela, Koh, Pang Wei, Deng, Tianda Z., Sinha, Rahul, Tsai, Jonathan M., Barkal, Amira A., Shen, Kimberle Y., Jain, Rajan, Morganti, Rachel M., Shyh-Chang, Ng, Fernhoff, Nathaniel B., George, Benson M., Wernig, Gerlinde, Salomon, Rachel E.A., Chen, Zhenghao, Vogel, Hannes, Epstein, Jonathan A., Kundaje, Anshul, Talbot, William S., Beachy, Philip A., Ang, Lay Teng, Weissman, Irving L.

“…Stem-cell differentiation to desired lineages requires navigating alternating developmental paths that often lead to unwanted cell types. Hence, comprehensive…”
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Where Hematopoietic Stem Cells Live: The Bone Marrow Niche by Szade, Krzysztof, Gulati, Gunsagar S, Chan, Charles K F, Kao, Kevin S, Miyanishi, Masanori, Marjon, Kristopher D, Sinha, Rahul, George, Benson M, Chen, James Y, Weissman, Irving L

“…Hematopoietic stem cells (HSCs) can sustain the production of blood throughout one's lifetime. However, for proper self-renewal of its own population and…”
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Effects of mechanical loading on cortical defect repair using a novel mechanobiological model of bone healing by Liu, Chao, Carrera, Robert, Flamini, Vittoria, Kenny, Lena, Cabahug-Zuckerman, Pamela, George, Benson M., Hunter, Daniel, Liu, Bo, Singh, Gurpreet, Leucht, Philipp, Mann, Kenneth A., Helms, Jill A., Castillo, Alesha B.

“…Mechanical loading is an important aspect of post-surgical fracture care. The timing of load application relative to the injury event may differentially…”
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Identification of tumorigenic cells and therapeutic targets in pancreatic neuroendocrine tumors by Krampitz, Geoffrey Wayne, George, Benson M., Willingham, Stephen B., Volkmer, Jens-Peter, Weiskopf, Kipp, Jahchan, Nadine, Newman, Aaron M., Sahoo, Debashis, Zemek, Allison J., Yanovsky, Rebecca L., Nguyen, Julia K., Schnorr, Peter J., Mazur, Pawel K., Sage, Julien, Longacre, Teri A., Visser, Brendan C., Poultsides, George A., Norton, Jeffrey A., Weissman, Irving L.

“…Pancreatic neuroendocrine tumors (PanNETs) are a type of pancreatic cancer with limited therapeutic options. Consequently, most patients with advanced disease…”
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Neutrophil and monocyte kinetics play critical roles in mouse peritoneal adhesion formation by Tsai, Jonathan M., Shoham, Maia, Fernhoff, Nathaniel B., George, Benson M., Marjon, Kristopher D., McCracken, Melissa N., Kao, Kevin S., Sinha, Rahul, Volkmer, Anne Kathrin, Miyanishi, Masanori, Seita, Jun, Rinkevich, Yuval, Weissman, Irving L.

“…Peritoneal adhesions are pathological fibroses that ensnare organs after abdominal surgery. This dense connective tissue can cause small bowel obstruction,…”
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Small RNAs are modified with N-glycans and displayed on the surface of living cells by Flynn, Ryan A., Pedram, Kayvon, Malaker, Stacy A., Batista, Pedro J., Smith, Benjamin A.H., Johnson, Alex G., George, Benson M., Majzoub, Karim, Villalta, Peter W., Carette, Jan E., Bertozzi, Carolyn R.

“…Glycans modify lipids and proteins to mediate inter- and intramolecular interactions across all domains of life. RNA is not thought to be a major target of…”
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Single-cell analysis reveals T cell infiltration in old neurogenic niches by Dulken, Ben W., Buckley, Matthew T., Navarro Negredo, Paloma, Saligrama, Naresha, Cayrol, Romain, Leeman, Dena S., George, Benson M., Boutet, Stéphane C., Hebestreit, Katja, Pluvinage, John V., Wyss-Coray, Tony, Weissman, Irving L., Vogel, Hannes, Davis, Mark M., Brunet, Anne

“…The mammalian brain contains neurogenic niches that comprise neural stem cells and other cell types. Neurogenic niches become less functional with age, but how…”
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Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity by Ring, Nan Guo, Herndler-Brandstetter, Dietmar, Weiskopf, Kipp, Shan, Liang, Volkmer, Jens-Peter, George, Benson M., Lietzenmayer, Melanie, McKenna, Kelly M., Naik, Tejaswitha J., McCarty, Aaron, Zheng, Yunjiang, Ring, Aaron M., Flavell, Richard A., Weissman, Irving L.

“…Cancer immunotherapy has emerged as a promising therapeutic intervention. However, complete and durable responses are only seen in a fraction of patients who…”
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Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes by Sockolosky, Jonathan T, Trotta, Eleonora, Parisi, Giulia, Picton, Lora, Su, Leon L, Le, Alan C, Chhabra, Akanksha, Silveria, Stephanie L, George, Benson M, King, Indigo C, Tiffany, Matthew R, Jude, Kevin, Sibener, Leah V, Baker, David, Shizuru, Judith A, Ribas, Antoni, Bluestone, Jeffrey A, Garcia, K Christopher

“…Interleukin-2 (IL-2) is a cytokine required for effector T cell expansion, survival, and function, especially for engineered T cells in adoptive cell…”
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Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma by Ji, Andrew L., Rubin, Adam J., Thrane, Kim, Jiang, Sizun, Reynolds, David L., Meyers, Robin M., Guo, Margaret G., George, Benson M., Mollbrink, Annelie, Bergenstråhle, Joseph, Larsson, Ludvig, Bai, Yunhao, Zhu, Bokai, Bhaduri, Aparna, Meyers, Jordan M., Rovira-Clavé, Xavier, Hollmig, S. Tyler, Aasi, Sumaira Z., Nolan, Garry P., Lundeberg, Joakim, Khavari, Paul A.

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Aneuploidy Drives Genomic Instability in Yeast by Sheltzer, Jason M., Blank, Heidi M., Pfau, Sarah J., Tange, Yoshie, George, Benson M., Humpton, Timothy J., Brito, Ilana L., Hiraoka, Yasushi, Niwa, Osami, Amon, Angelika

“…Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by…”
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Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5⁺ mouse long-term hematopoietic stem cells by Gulati, Gunsagar S., Zukowska, Monika, Noh, Joseph J., Zhang, Allison, Wesche, Daniel J., Sinha, Rahul, George, Benson M., Weissman, Irving L., Szade, Krzysztof

“…Hematopoietic stem cells (HSCs) self-renew and generate all blood cells. Recent studies with single cell transplants and lineage tracing suggest that adult…”
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Design of a mucin-selective protease for targeted degradation of cancer-associated mucins by Pedram, Kayvon, Shon, D. Judy, Tender, Gabrielle S., Mantuano, Natalia R., Northey, Jason J., Metcalf, Kevin J., Wisnovsky, Simon P., Riley, Nicholas M., Forcina, Giovanni C., Malaker, Stacy A., Kuo, Angel, George, Benson M., Miller, Caitlyn L., Casey, Kerriann M., Vilches-Moure, José G., Ferracane, Michael J., Weaver, Valerie M., Läubli, Heinz, Bertozzi, Carolyn R.

“…Targeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Here, to expand the landscape of targetable…”
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Antibody Conditioning Enables MHC-Mismatched Hematopoietic Stem Cell Transplants and Organ Graft Tolerance by George, Benson M., Kao, Kevin S., Kwon, Hye-Sook, Velasco, Brenda J., Poyser, Jessica, Chen, Angela, Le, Alan C., Chhabra, Akanksha, Burnett, Cassandra E., Cajuste, Devon, Hoover, Malachia, Loh, Kyle M., Shizuru, Judith A., Weissman, Irving L.

“…Hematopoietic cell transplantation can correct hematological and immunological disorders by replacing a diseased blood system with a healthy one, but this…”
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Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain by Buckley, Matthew T, Sun, Eric D, George, Benson M, Liu, Ling, Schaum, Nicholas, Xu, Lucy, Reyes, Jaime M, Goodell, Margaret A, Weissman, Irving L, Wyss-Coray, Tony, Rando, Thomas A, Brunet, Anne

“…The diversity of cell types is a challenge for quantifying aging and its reversal. Here we develop 'aging clocks' based on single-cell transcriptomics to…”
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Normal and Neoplastic Stem Cells by McCracken, Melissa N, George, Benson M, Kao, Kevin S, Marjon, Kristopher D, Raveh, Tal, Weissman, Irving L

“…A stem cell is broadly defined as a cell that retains the capacity to self-renew, a feature that confers the ability to continuously make identical daughter…”
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