Search Results - "George, B S"

Mitochondrial calcium uptake by Williams, George S. B., Boyman, Liron, Chikando, Aristide C., Khairallah, Ramzi J., Lederer, W. J.

“…Calcium (Ca²⁺) uptake into the mitochondrial matrix is critically important to cellular function. As a regulator of matrix Ca²⁺ levels, this flux influences…”
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Stimulated Emission Depletion Live-Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction by Wagner, Eva, Lauterbach, Marcel A, Kohl, Tobias, Westphal, Volker, Williams, George S.B, Steinbrecher, Julia H, Streich, Jan-Hendrik, Korff, Brigitte, Tuan, Hoang-Trong M, Hagen, Brian, Luther, Stefan, Hasenfuss, Gerd, Parlitz, Ulrich, Jafri, M Saleet, Hell, Stefan W, Lederer, W Jonathan, Lehnart, Stephan E

“…RATIONALE:Transverse tubules (TTs) couple electric surface signals to remote intracellular Ca release units (CRUs). Diffraction-limited imaging studies have…”
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Chronic Sympathetic Hyperactivity Triggers Electrophysiological Remodeling and Disrupts Excitation-Contraction Coupling in Heart by Joca, Humberto C., Santos‐Miranda, Artur, Joviano-Santos, Julliane V., Maia-Joca, Rebeca P. M., Brum, Patricia C., Williams, George S. B., Cruz, Jader S.

“…The sympathetic nervous system is essential for maintenance of cardiac function via activation of post-junctional adrenergic receptors. Prolonged adrenergic…”
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The growing importance of mitochondrial calcium in health and disease by Boyman, Liron, Williams, George S. B., Lederer, W. J.

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Superresolution Modeling of Calcium Release in the Heart by Walker, Mark A., Williams, George S.B., Kohl, Tobias, Lehnart, Stephan E., Jafri, M. Saleet, Greenstein, Joseph L., Lederer, W.J., Winslow, Raimond L.

“…Stable calcium-induced calcium release (CICR) is critical for maintaining normal cellular contraction during cardiac excitation-contraction coupling. The…”
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Dynamics of Calcium Sparks and Calcium Leak in the Heart by Williams, George S.B., Chikando, Aristide C., Tuan, Hoang-Trong M., Sobie, Eric A., Lederer, W.J., Jafri, M. Saleet

“…We present what we believe to be a new mathematical model of Ca2+ leak from the sarcoplasmic reticulum (SR) in the heart. To our knowledge, it is the first to…”
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Calcium Movement in Cardiac Mitochondria by Boyman, Liron, Chikando, Aristide C., Williams, George S.B., Khairallah, Ramzi J., Kettlewell, Sarah, Ward, Christopher W., Smith, Godfrey L., Kao, Joseph P.Y., Lederer, W. Jonathan

“…Existing theory suggests that mitochondria act as significant, dynamic buffers of cytosolic calcium ([Ca2+]i) in heart. These buffers can remove up to…”
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Models of cardiac excitation–contraction coupling in ventricular myocytes by Williams, George S.B., Smith, Gregory D., Sobie, Eric A., Jafri, M. Saleet

“…Mathematical and computational modeling of cardiac excitation–contraction coupling has produced considerable insights into how the heart muscle contracts. With…”
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Mitochondrial calcium and the regulation of metabolism in the heart by Williams, George S.B, Boyman, Liron, Lederer, W. Jonathan

“…Abstract Consumption of adenosine triphosphate (ATP) by the heart can change dramatically as the energetic demands increase from a period of rest to strenuous…”
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Axial tubule junctions control rapid calcium signaling in atria by Brandenburg, Sören, Kohl, Tobias, Williams, George S B, Gusev, Konstantin, Wagner, Eva, Rog-Zielinska, Eva A, Hebisch, Elke, Dura, Miroslav, Didié, Michael, Gotthardt, Michael, Nikolaev, Viacheslav O, Hasenfuss, Gerd, Kohl, Peter, Ward, Christopher W, Lederer, W Jonathan, Lehnart, Stephan E

“…The canonical atrial myocyte (AM) is characterized by sparse transverse tubule (TT) invaginations and slow intracellular Ca2+ propagation but exhibits rapid…”
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NCLX: The mitochondrial sodium calcium exchanger by Boyman, Liron, Williams, George S.B, Khananshvili, Daniel, Sekler, Israel, Lederer, W.J

“…Abstract The free Ca 2 + concentration within the mitochondrial matrix ([Ca 2 + ]m ) regulates the rate of ATP production and other [Ca 2 + ]m sensitive…”
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Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes by Greiser, Maura, Kerfant, Benoît-Gilles, Williams, George S B, Voigt, Niels, Harks, Erik, Dibb, Katharine M, Giese, Anne, Meszaros, Janos, Verheule, Sander, Ravens, Ursula, Allessie, Maurits A, Gammie, James S, van der Velden, Jolanda, Lederer, W Jonathan, Dobrev, Dobromir, Schotten, Ulrich

“…Atrial fibrillation (AF) is characterized by sustained high atrial activation rates and arrhythmogenic cellular Ca2+ signaling instability; however, it is not…”
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Moment Closure for Local Control Models of Calcium-Induced Calcium Release in Cardiac Myocytes by Williams, George S.B., Huertas, Marco A., Sobie, Eric A., Jafri, M. Saleet, Smith, Gregory D.

“…In prior work, we introduced a probability density approach to modeling local control of Ca 2+-induced Ca 2+ release in cardiac myocytes, where we derived…”
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Quantitative tests reveal that microtubules tune the healthy heart but underlie arrhythmias in pathology by Joca, Humberto C., Coleman, Andrew K., Ward, Chris W., Williams, George S. B.

“…Key points Our group previously discovered and characterized the microtubule mechanotransduction pathway linking diastolic stretch to NADPH oxidase 2‐derived…”
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Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction by FLAHERTY, J. T, PITT, B, BRINKER, J. A, BECKER, L. C, MANCINI, J, TOPOL, E, WERNS, S. W, GRUBER, J. W, HEUSER, R. R, ROTHBAUM, D. A, BURWELL, L. R, GEORGE, B. S, KEREIAKES, D. J, DEITCHMAN, D, GUSTAFSON, N

“…Animal studies have demonstrated a burst of oxygen free radical generation after reperfusion of ischemic myocardium that could be blocked by administration of…”
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Egg quality, larval growth and phenotypic plasticity in a forcipulate seastar by George, Sophie B

“…The present study provides the first clear evidence of larval developmental plasticity in forcipulate seastars and a relationship between egg size and…”
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Ryanodine receptor sensitivity governs the stability and synchrony of local calcium release during cardiac excitation-contraction coupling by Wescott, Andrew P, Jafri, M. Saleet, Lederer, W.J, Williams, George S.B

“…Abstract Calcium-induced calcium release is the principal mechanism that triggers the cell-wide [Ca 2 + ]i transient that activates muscle contraction during…”
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The Physiological and Biochemical Response of Ribbed Mussels to Rising Temperatures: Benefits of Salt Marsh Cordgrass by Smith, A, Erber, J, Watson, A, Johnson, C, Gato, W E, George, S B

“…Synopsis Salt marsh ecosystems are heavily reliant on ribbed mussel (Geukensia demissa) populations to aid in rapid recovery from droughts. The focus of this…”
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Ambiguous interactions between diastolic and SR Ca2+ in the regulation of cardiac Ca2+ release by Sobie, Eric A., Williams, George S.B., Lederer, W.J.

“…Sobie et al. highlight unresolved issues concerning the regulation of sarcoplasmic reticulum calcium release in cardiac myocytes…”
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Pharmacodynamics of chimeric glycoprotein IIb/IIIa integrin antiplatelet antibody Fab 7E3 in high-risk coronary angioplasty by Tcheng, J E, Ellis, S G, George, B S, Kereiakes, D J, Kleiman, N S, Talley, J D, Wang, A L, Weisman, H F, Califf, R M, Topol, E J

“…Thrombosis has been implicated as central to the clinical complications of coronary angioplasty (PTCA). Chimeric monoclonal 7E3 Fab (c7E3 Fab) is the first of…”
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