Search Results - "Georgatos, S D"

The lamin B receptor (LBR) provides essential chromatin docking sites at the nuclear envelope by Pyrpasopoulou, A., Meier, J., Maison, C., Simos, G., Georgatos, S. D.

“…Morphological studies have established that peripheral heterochromatin is closely associated with the nuclear envelope. The tight coupling of the two…”
Get full text

A Lamin B Receptor in the Nuclear Envelope by Worman, Howard J., Yuan, Jeffrey, Blobel, Günter, Georgatos, Spyros D.

“…Using a solution binding assay, we show that purified 125I-labeled lamin B binds in a saturable and specific fashion to lamin-depleted avian erythrocyte…”
Get full text

Lamin B Constitutes an Intermediate Filament Attachment Site at the Nuclear Envelope by Georgatos, Spyros D., Blobel, Günter

“…We found that urea extraction of turkey erythrocyte nuclear envelopes abolished their ability to bind exogenous125I-vimentin, while, at the same time, it…”
Get full text

Two Distinct Attachment Sites for Vimentin along the Plasma Membrane and the Nuclear Envelope in Avian Erythrocytes: A Basis for a Vectorial Assembly of Intermediate Filaments by Georgatos, Spyros D., Blobel, Günter

“…In vitro binding studies with isolated bovine lens vimentin and avian erythrocyte membranes reveal the existence of two functionally distinct sets of…”
Get full text

Binding of lamin A to polynucleosomes by YUAN, J, SIMOS, G, BLOBEL, G, GEORGATOS, S. D

“…Morphological observations suggest a close association between heterochromatin and the nuclear lamina. To investigate the molecular aspects of this…”
Get full text

Type B lamins remain associated with the integral nuclear envelope protein p58 during mitosis: implications for nuclear reassembly by Meier, J., Georgatos, S.D.

“…p58 (also referred to as the lamin B receptor) is an integral membrane protein of the nuclear envelope known to form a multimeric complex with the lamins and…”
Get full text

Taxol affects nuclear lamina and pore complex organization and inhibits import of karyophilic proteins into the cell nucleus by THEODOROPOULOS, P. A, POLIOUDAKI, H, KOSTAKI, O, DERDAS, S. P, GEORGOULIAS, V, DARGEMONT, C, GEORGATOS, S. D

“…Treatment of human carcinoma cells with Taxol induces focal unraveling of the nuclear lamina and extensive clustering or ectopic localization of the nuclear…”
Get full text

Filensin: A New Vimentin-Binding, Polymerization-Competent, and Membrane-Associated Protein of the Lens Fiber Cell by Merdes, Andreas, Brunkener, Mariann, Horstmann, Heinz, Georgatos, Spyros D.

“…We have studied the molecular properties of a 100-kD protein, termed filensin, which we have isolated from porcine lens membranes. Filensin represents a…”
Get full text

Binding of Two Desmin Derivatives to the Plasma Membrane and the Nuclear Envelope of Avian Erythrocytes: Evidence for a Conserved Site-Specificity in Intermediate Filament-Membrane Interactions by Georgatos, Spyros D., Weber, Klaus, Geisler, Norbert, Blobel, Gunter

“…Using solution binding assays, we found that a 45-kDa fragment of desmin, lacking 67 residues from the N terminus, could specifically associate with avian…”
Get full text

The 47-kD Lens-Specific Protein Phakinin Is a Tailless Intermediate Filament Protein and an Assembly Partner of Filensin by Merdes, Andreas, Gounari, Fotini, Georgatos, Spyros D.

“…In previous studies we have characterized a lens-specific intermediate filament (IF) protein, termed filensin. Filensin does not self-assemble into regular IFs…”
Get full text

Regulated Docking of Nuclear Membrane Vesicles to Vimentin Filaments during Mitosis by Maison, Christèle, Horstmann, Heinz, Georgatos, Spyros D.

“…During mitosis, several types of intermediate-sized filaments (IFs) undergo an extensive remodelling in response to phosphorylation by cdc 2 and other protein…”
Get full text

Heterotypic and Homotypic Associations between the Nuclear Lamins: Site-Specificity and Control by Phosphorylation by Georgatos, Spyros D., Stournaras, Christos, Blobel, Günter

“…Using purified components in affinity chromatography and blot binding assays, we have found that rat liver lamins A, B, and C can associate in homotypic and…”
Get full text

A Potential Role for the COOH-Terminal Domain in the Lateral Packing of Type III Intermediate Filaments by Kouklis, Panos D., Papamarcaki, Thomais, Merdes, Andreas, Georgatos, Spyros D.

“…To identify sites of self-association in type III intermediate filament (IF) proteins, we have taken an "anti-idiotypic antibody" approach. A mAb (anti-Ct),…”
Get full text

Dynamics of intermediate filaments: Recent progress and unanswered questions by Georgatos, Spyros D.

“…Intermediate filaments (IFs) have always been considered as the most static and ‘skeletal’ cellular elements. This view is now changing: new information…”
Get full text

Nuclear lamina heterogeneity in mammalian cells. Differential expression of the major lamins and variations in lamin B phosphorylation by Worman, H J, Lazaridis, I, Georgatos, S D

“…We have studied the molecular composition of the nuclear lamina in rat tissues of distinct embryological origin and the occurrence of the nuclear lamins during…”
Get full text

The Inner Nuclear Membrane Protein Lamin B Receptor Forms Distinct Microdomains and Links Epigenetically Marked Chromatin to the Nuclear Envelope by Makatsori, Dimitra, Kourmouli, Niki, Polioudaki, Hara, Shultz, Leonard D., Mclean, Kelvin, Theodoropoulos, Panayiotis A., Singh, Prim B., Georgatos, Spyros D.

“…Using heterochromatin-enriched fractions, we have detected specific binding of mononucleosomes to the N-terminal domain of the inner nuclear membrane protein…”
Get full text

Lamin A, Lamin B, and Lamin B Receptor Analogues in Yeast by Georgatos, Spyros D., Maroulakou, Ioanna, Blobel, Günter

“…Previous studies have shown that turkey erythrocyte lamin B is anchored to the nuclear envelope via a 58-kD integral membrane protein termed p58 or lamin B…”
Get full text

The Binding of Vimentin to Human Erythrocyte Membranes: A Model System for the Study of Intermediate Filament-Membrane Interactions by Georgatos, Spyros D., Marchesi, Vincent T.

“…We have characterized the association of the intermediate filament protein, vimentin, with the plasma membrane, using radioiodinated lens vimentin and various…”
Get full text

Network antibodies identify nuclear lamin B as a physiological attachment site for peripherin intermediate filaments by Djabali, K, Portier, M M, Gros, F, Blobel, G, Georgatos, S D

“…We studied the molecular associations between peripherin (a neuronal, type III intermediate filament subunit) and nuclear lamins. We show here that isolated…”
Get more information

Histones H3/H4 form a tight complex with the inner nuclear membrane protein LBR and heterochromatin protein 1 by Polioudaki, Hara, Kourmouli, Niki, Drosou, Victoria, Bakou, Alexandra, Theodoropoulos, Panayiotis A, Singh, Prim B, Giannakouros, Thomas, Georgatos, Spyros D

“…We have recently shown that heterochromatin protein 1 (HP1) interacts with the nuclear envelope in an acetylation‐dependent manner. Using purified components…”
Get full text