Search Results - "Georgakis, Georgios V."

Design and radiosynthesis of class-IIa HDAC inhibitor with high molar activity via repositioning the 18F-radiolabel by Xu, Sulan, Huang, Chun-Han, Eyermann, Christopher, Georgakis, Georgios V., Turkman, Nashaat

“…The design and radiosynthesis of [ 18 F]NT376, a high potency inhibitor of class-IIa histone deacetylases (HDAC) is reported. We utilized a three-step…”
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Development of a Radiolabeled Cyclin-Dependent Kinases 4 and 6 (CDK4/6) Inhibitor for Brain and Cancer PET Imaging by Huang, Chun-Han, Khan, Palwasha, Xu, Sulan, Cohen, Jules, Georgakis, Georgios V, Turkman, Nashaat

“…The synthesis, biochemical evaluation and radiosynthesis of a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor and radioligand was performed. NT431, a newly…”
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Development of Patient-Derived Gastric Cancer Organoids from Endoscopic Biopsies and Surgical Tissues by Gao, Mei, Lin, Miranda, Rao, Manisha, Thompson, Hannah, Hirai, Kelsi, Choi, Minsig, Georgakis, Georgios V., Sasson, Aaron R., Bucobo, Juan Carlos, Tzimas, Demetri, D’Souza, Lionel S., Buscaglia, Jonathan M., Davis, James, Shroyer, Kenneth R., Li, Jinyu, Powers, Scott, Kim, Joseph

“…Background Organoids are three-dimensional in vitro models of human disease developed from benign and malignant gastrointestinal tissues with tremendous…”
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Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines by Buglio, Daniela, Georgakis, Georgios V., Hanabuchi, Shino, Arima, Kazuhiko, Khaskhely, Noor M., Liu, Yong-Jun, Younes, Anas

“…Epigenetic changes have been implicated in silencing several B-cell genes in Hodgkin and Reed-Sternberg cells (HRS) of Hodgkin lymphoma (HL), and this…”
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Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL‐R1 and TRAIL‐R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin‐ and bortezomib‐induced cell death by Georgakis, Georgios V., Li, Yang, Humphreys, Robin, Andreeff, Michael, O'Brien, Susan, Younes, Mamoun, Carbone, Antonino, Albert, Vivian, Younes, Anas

“…Summary Tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL/Apo2L) is a death protein that preferentially kills tumour cells while sparing normal…”
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Inhibition of Heat Shock Protein 90 Function by 17-Allylamino-17-Demethoxy-Geldanamycin in Hodgkin's Lymphoma Cells Down-Regulates Akt Kinase, Dephosphorylates Extracellular Signal–Regulated Kinase, and Induces Cell Cycle Arrest and Cell Death by GEORGAKIS, Georgios V, YANG LI, RASSIDAKIS, Georgios Z, MARTINEZ-VALDEZ, Hector, MEDEIROS, L. Jeffrey, YOUNES, Anas

“…Purpose: Heat shock protein 90 (HSP90) is a chaperone for several client proteins involved in transcriptional regulation, signal transduction, and cell cycle…”
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The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells by Luqman, Mohammad, Klabunde, Sha, Lin, Karen, Georgakis, Georgios V., Cherukuri, Anu, Holash, Jocelyn, Goldbeck, Cheryl, Xu, Xiaomei, Kadel, Edward E., Lee, Sang Hoon, Aukerman, Sharon Lea, Jallal, Bahija, Aziz, Natasha, Weng, Wen-Kai, Wierda, William, O'Brien, Susan, Younes, Anas

“…B-cell chronic lymphocytic leukemia (B-CLL) is a lymphoproliferative disorder characterized by the surface expression of CD20, CD5 antigens, as well as the…”
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Inhibition of the phosphatidylinositol‐3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma by Georgakis, Georgios V., Li, Yang, Rassidakis, Georgios Z., Medeiros, L. Jeffrey, Mills, Gordon B., Younes, Anas

“…Summary Activation of the phosphatidylinositol 3‐kinase (PI3K) pathway has been linked with tumour cell growth, survival and resistance to therapy in several…”
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Induction of Cell Cycle Arrest and Apoptosis by the Proteasome Inhibitor PS-341 in Hodgkin Disease Cell Lines Is Independent of Inhibitor of Nuclear Factor-κB Mutations or Activation of the CD30, CD40, and RANK Receptors by Zheng, Bei, Georgakis, Georgios V., Li, Yang, Bharti, Alok, McConkey, David, Aggarwal, Bharat B., Younes, Anas

“…Purpose: The malignant Hodgkin and Reed-Sternberg cells of Hodgkin disease (HD) are known to constitutively express high levels of activated nuclear factor κB…”
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Direct therapeutic targeting of immune checkpoint PD-1 in pancreatic cancer by Gao, Mei, Lin, Miranda, Moffitt, Richard A., Salazar, Marcela A., Park, Jinha, Vacirca, Jeffrey, Huang, Chuan, Shroyer, Kenneth R., Choi, Minsig, Georgakis, Georgios V., Sasson, Aaron R., Talamini, Mark A., Kim, Joseph

“…Background Pancreatic cancer (PC) hijacks innate cellular processes to promote cancer growth. We hypothesized that PC exploits PD-1/PD-L1 not only to avoid…”
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ASO Visual Abstract: A Multicenter, Phase 1, Trial Evaluating Nanoliposomal Irinotecan for Heated Intraperitoneal Chemotherapy Combined with Cytoreductive Surgery in Patients with Peritoneal Surface Disease by Choi, Minsig, Harper, Megan M., Pandalai, Prakash K., Abdel-Misih, Sherif R. Z., Patel, Reema A., Ellis, Carleton S., Reusch, Ellen, Reynolds, Jeri, Vacchi-Suzzi, Caterina, Park, Jinha M., Georgakis, Georgios V., Kim, Joseph

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A Multicenter Phase 1 Trial Evaluating Nanoliposomal Irinotecan for Heated Intraperitoneal Chemotherapy Combined with Cytoreductive Surgery for Patients with Peritoneal Surface Disease by Choi, Minsig, Harper, Megan M., Pandalai, Prakash K., Abdel-Misih, Sherif R. Z., Patel, Reema A., Ellis, Carleton S., Reusch, Ellen, Reynolds, Jeri, Vacchi-Suzzi, Caterina, Park, Jinha M., Georgakis, Georgios V., Kim, Joseph

“…Background Nanoliposomal irinotecan (nal-IRI) is a promising novel hyperthermic intraperitoneal chemotherapy (HIPEC) agent given its enhanced efficacy against…”
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Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma by Yazbeck, Victor Y, Buglio, Daniela, Georgakis, Georgios V, Li, Yang, Iwado, Eiji, Romaguera, Jorge E, Kondo, Seiji, Younes, Anas

“…Objective To investigate the mechanisms of antiproliferative effect induced by the mammalian target of rapamycin (mTOR) inhibitor temsirolimus in mantle cell…”
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Correction: Direct therapeutic targeting of immune checkpoint PD-1 in pancreatic cancer by Gao, Mei, Lin, Miranda, Moffitt, Richard A., Salazar, Marcela A., Park, Jinha, Vacirca, Jeffrey, Huang, Chuan, Shroyer, Kenneth R., Choi, Minsig, Georgakis, Georgios V., Sasson, Aaron R., Talamini, Mark A., Kim, Joseph

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Prognostic significance of serum B-lymphocyte stimulator level in Hodgkin's lymphoma by Oki, Yasuhiro, Georgakis, Georgios V, Migone, Thi-Sau, Kwak, Larry W, Younes, Anas

“…Department of Lymphoma and Myeloma, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, 77030 and Department of Clinical Immunoassays, Human…”
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The heat shock protein 90 inhibitor 17‐AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9 by Georgakis, Georgios V., Li, Yang, Younes, Anas

“…Summary Mantle cell lymphoma (MCL), a distinct type of non‐Hodgkin lymphoma, is characterised by the overexpression of cyclin D1. Heat shock protein 90 (HSP90)…”
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Case report of intestinal non-rotation, heterotaxy, and polysplenia in a patient with pancreatic cancer by Pagkratis, Spyridon, Kryeziu, Sara, Lin, Miranda, Hoque, Samah, Bucobo, Juan Carlos, Buscaglia, Jonathan M., Georgakis, Georgios V., Sasson, Aaron R., Kim, Joseph

“…Heterotaxy with polysplenia is an extremely rare congenital condition resulting from abnormal arrangement of organs in the abdominal and thoracic cavities…”
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From Rapa Nui to rapamycin: targeting PI3K/Akt/mTOR for cancer therapy by Georgakis, Georgios V, Younes, Anas

“…One of the most prominent pathways explored in the area of targeted therapy is the PI3K/Akt/mTOR pathway, which plays a central role in cell survival and…”
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Heat-shock protein 90 inhibitors in cancer therapy: 17AAG and beyond by Georgakis, Georgios V, Younes, Anas

“…Heat-shock protein 90 (HSP90) has diverse functions in mammalian cells. It acts as molecular chaperone, together with several co-chaperone molecules (such as…”
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The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression by Georgakis, Georgios V., Li, Yang, Rassidakis, Georgios Z., Medeiros, L. Jeffrey, Younes, Anas

“…Heat shock protein 90 (HSP90) chaperones and maintains the molecular integrity of a variety of signal transduction proteins, including the…”
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