Search Results - "Georgakilas, Alexandros"

The challenge of drug resistance in cancer treatment: a current overview by Nikolaou, Michail, Pavlopoulou, Athanasia, Georgakilas, Alexandros G., Kyrodimos, Efthymios

“…It is generally accepted that recent advances in anticancer agents have contributed significantly to the improvement of both the disease-free survival and…”
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p21: A Two-Faced Genome Guardian by Georgakilas, Alexandros G, Martin, Olga A, Bonner, William M

“…Upon DNA damage or other stressors, the tumor suppressor p53 is activated, leading to transient expression of the cyclin-dependent kinase inhibitor (CKI) p21…”
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Toxicity and adverse effects of Tamoxifen and other anti-estrogen drugs by YANG, Geniey, NOWSHEEN, Somaira, AZIZ, Khaled, GEORGAKILAS, Alexandros G

“…Breast cancer is a heterogeneous disease affecting thousands of people every year. Multiple factors are responsible in causing breast cancer while a number of…”
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Formation of Clustered DNA Damage after High-LET Irradiation：A Review by Hada, Megumi, Georgakilas, Alexandros G

“…Radiation can cause as well as cure cancer. The risk of developing radiation-induced cancer has traditionally been estimated from cancer incidence among…”
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Induction and Repair of Clustered DNA Lesions: What Do We Know So Far? by Georgakilas, Alexandros G., O'Neill, Peter, Stewart, Robert D.

“…The accumulated evidence in the literature indicates that a cluster of two or more lesions within one or two helical turns of the DNA is more challenging to…”
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Low dose ionizing radiation effects on the immune system by Lumniczky, Katalin, Impens, Nathalie, Armengol, Gemma, Candéias, Serge, Georgakilas, Alexandros G., Hornhardt, Sabine, Martin, Olga A., Rödel, Franz, Schaue, Dörthe

“…•Immune alterations are present in many ionizing radiation-induced adverse health outcomes.•Low doses of ionizing radiation induce subtle but persistent immune…”
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Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis by Mavragani, Ifigeneia V, Nikitaki, Zacharenia, Souli, Maria P, Aziz, Asef, Nowsheen, Somaira, Aziz, Khaled, Rogakou, Emmy, Georgakilas, Alexandros G

“…Cellular effects of ionizing radiation (IR) are of great variety and level, but they are mainly damaging since radiation can perturb all important components…”
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Oxidative stress, DNA methylation and carcinogenesis by Franco, Rodrigo, Schoneveld, Onard, Georgakilas, Alexandros G, Panayiotidis, Mihalis I

“…Abstract Transformation of a normal cell to a malignant one requires phenotypic changes often associated with each of the initiation, promotion and progression…”
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Ionizing Radiation and Complex DNA Damage: From Prediction to Detection Challenges and Biological Significance by Mavragani, Ifigeneia V, Nikitaki, Zacharenia, Kalospyros, Spyridon A, Georgakilas, Alexandros G

“…Biological responses to ionizing radiation (IR) have been studied for many years, generally showing the dependence of these responses on the quality of…”
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Ionizing radiation-induced circulatory and metabolic diseases by Tapio, Soile, Little, Mark P., Kaiser, Jan Christian, Impens, Nathalie, Hamada, Nobuyuki, Georgakilas, Alexandros G., Simar, David, Salomaa, Sisko

“…•Ionizing radiation causes adverse circulatory and metabolic effects at high doses.•Low-dose radiation is causally associated with circulatory disease.•Impact…”
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Recent Advances in Cancer Therapy Based on Dual Mode Gold Nanoparticles by Spyratou, Ellas, Makropoulou, Mersini, Efstathopoulos, Efstathios P, Georgakilas, Alexandros G, Sihver, Lembit

“…Many tumor-targeted strategies have been used worldwide to limit the side effects and improve the effectiveness of therapies, such as chemotherapy,…”
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Editorial: Metal nanoparticles in cancer: detection, diagnosis, therapy and their pharmacological assessment by Peana, Massimiliano, Georgakilas, Alexandros G

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The Role of Human Endogenous Retroviruses in Cancer Immunotherapy of the Post-COVID-19 World by Logotheti, Stella, Stiewe, Thorsten, Georgakilas, Alexandros G

“…At the outbreak of the COVID-19 global crisis, diverse scientific groups suggested that this unprecedented emergency could act as a ‘blessing in disguise’ [...]…”
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Codon Usage and Phenotypic Divergences of SARS-CoV-2 Genes by Dilucca, Maddalena, Forcelloni, Sergio, Georgakilas, Alexandros G, Giansanti, Andrea, Pavlopoulou, Athanasia

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first occurred in Wuhan (China) in December of 2019, causes a severe acute respiratory…”
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Role of the immune system and inflammation in ionizing radiation effects by Georgakilas, Alexandros G

“…[...]I would like to sincerely express my high appreciation to all authors and groups contributing their time, knowledge and expertise to this Special Issue of…”
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Determinants of resistance to chemotherapy and ionizing radiation in breast cancer stem cells by Pavlopoulou, Athanasia, Oktay, Yavuz, Vougas, Konstantinos, Louka, Maria, Vorgias, Constantinos E., Georgakilas, Alexandros G.

“…•Determinants of anti-oncogenic treatment resistance in breast cancer stem cells by the use of bioinformatics.•Mechanisms underlying stemness,…”
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Codon usage bias in radioresistant bacteria by Dilucca, Maddalena, Pavlopoulou, Athanasia, Georgakilas, Alexandros G., Giansanti, Andrea

“…The relationship between patterns of codon usage bias (CUB), the preferential usage of synonimous nucleotide triplets encoding the same amino acid, and…”
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Molecular determinants of radiosensitivity in normal and tumor tissue: A bioinformatic approach by Pavlopoulou, Athanasia, Bagos, Pantelis, Koutsandrea, Vasiliki, Georgakilas, Alexandros G

“…Abstract Although radiation therapy is a treatment of choice for cancer, a high percentage of patients develop adverse effects in normal tissue following…”
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More than Meets the Eye: Integration of Radiomics with Transcriptomics for Reconstructing the Tumor Microenvironment and Predicting Response to Therapy by Logotheti, Stella, Georgakilas, Alexandros G

“…For over a decade, large cancer-related datasets (big data) have continuously been produced and made publicly available to the scientific community [...]…”
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p73 isoforms meet evolution of metastasis by Logotheti, Stella, Pavlopoulou, Athanasia, Marquardt, Stephan, Takan, Işıl, Georgakilas, Alexandros G., Stiewe, Thorsten

“…Cancer largely adheres to Darwinian selection. Evolutionary forces are prominent during metastasis, the final and incurable disease stage, where cells acquire…”
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