Search Results - "Georg, T"

Redox-directed cancer therapeutics: molecular mechanisms and opportunities by Wondrak, Georg T

“…Redox dysregulation originating from metabolic alterations and dependence on mitogenic and survival signaling through reactive oxygen species represents a…”
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On the Pitfalls of Using Arbiter-PUFs as Building Blocks by Becker, Georg T.

“…Physical unclonable functions (PUFs) have emerged as a promising solution for securing resource-constrained embedded devices such as RFID tokens. PUFs use the…”
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Tunable Production of (R)- or (S)‑Citronellal from Geraniol via a Bienzymatic Cascade Using a Copper Radical Alcohol Oxidase and Old Yellow Enzyme by Ribeaucourt, David, Höfler, Georg T, Yemloul, Mehdi, Bissaro, Bastien, Lambert, Fanny, Berrin, Jean-Guy, Lafond, Mickael, Paul, Caroline E

“…Biocatalytic pathways for the synthesis of (−)-menthol, the most sold flavor worldwide, are highly sought-after. To access the key intermediate (R)-citronellal…”
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Robust Fuzzy Extractors and Helper Data Manipulation Attacks Revisited: Theory versus Practice by Becker, Georg T.

“…Fuzzy extractors have been proposed in 2004 by Dodis et al. as a secure way to generate cryptographic keys from noisy sources. In recent years, fuzzy…”
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Genomic GLO1 deletion modulates TXNIP expression, glucose metabolism, and redox homeostasis while accelerating human A375 malignant melanoma tumor growth by Jandova, Jana, Wondrak, Georg T.

“…Glyoxalase 1 (encoded by GLO1) is a glutathione-dependent enzyme detoxifying the glycolytic byproduct methylglyoxal (MG), an oncometabolite involved in…”
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Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy by Zheng, Hongting, Whitman, Samantha A, Wu, Wei, Wondrak, Georg T, Wong, Pak K, Fang, Deyu, Zhang, Donna D

“…To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal function…”
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Vemurafenib Drives Epithelial-to-Mesenchymal Transition Gene Expression in BRAF Inhibitor‒Resistant BRAFV600E/NRASQ61K Melanoma Enhancing Tumor Growth and Metastasis in a Bioluminescent Murine Model by Jandova, Jana, Wondrak, Georg T.

“…BRAF inhibitor (BRAFi) resistance compromises long-term survivorship of patients with malignant melanoma, and mutant NRAS is a major mediator of BRAFi…”
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An Essential Role of NRF2 in Diabetic Wound Healing by Long, Min, Rojo de la Vega, Montserrat, Wen, Qing, Bharara, Manish, Jiang, Tao, Zhang, Rui, Zhou, Shiwen, Wong, Pak K, Wondrak, Georg T, Zheng, Hongting, Zhang, Donna D

“…The high mortality and disability of diabetic nonhealing skin ulcers create an urgent need for the development of more efficacious strategies targeting…”
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TLR4-directed Molecular Strategies Targeting Skin Photodamage and Carcinogenesis by Dickinson, Sally E, Wondrak, Georg T

“…Exposure to solar ultraviolet (UV) radiation is a causative factor in skin photodamage and carcinogenesis, and inflammatory dysregulation is a key mechanism…”
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Exposure to chlorinated drinking water alters the murine fecal microbiota by Jandova, Jana, Schiro, Gabriele, Duca, Frank A., Laubitz, Daniel, Wondrak, Georg T.

“…An abundant body of scientific studies and regulatory guidelines substantiates antimicrobial efficacy of freshwater chlorination ensuring drinking water safety…”
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Solar simulated ultraviolet radiation inactivates HCoV-NL63 and SARS-CoV-2 coronaviruses at environmentally relevant doses by Wondrak, Georg T., Jandova, Jana, Williams, Spencer J., Schenten, Dominik

“…The germicidal properties of short wavelength ultraviolet C (UVC) light are well established and used to inactivate many viruses and other microbes. However,…”
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Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer by Snell, Jeremy A, Jandova, Jana, Wondrak, Georg T

“…A multitude of extrinsic environmental factors (referred to in their entirety as the 'skin exposome') impact structure and function of skin and its…”
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Bitstream Fault Injections (BiFI)-Automated Fault Attacks Against SRAM-Based FPGAs by Swierczynski, Pawel, Becker, Georg T., Moradi, Amir, Paar, Christof

“…This contribution is concerned with the question whether an adversary can automatically manipulate an unknown FPGA bitstream realizing a cryptographic…”
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TLR4 in skin cancer: From molecular mechanisms to clinical interventions by Dickinson, Sally E., Wondrak, Georg T.

“…The health and economic burden imposed by skin cancer is substantial, creating an urgent need for the development of improved molecular strategies for its…”
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Automated benchmark network diversification for realistic attack simulation with application to moving target defense by Bajic, Alexander, Becker, Georg T.

“…With numbers of exploitable vulnerabilities and attacks on networks constantly increasing, it is important to employ defensive techniques to protect one’s…”
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The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2-b]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes by Park, Sophia L., Justiniano, Rebecca, Williams, Joshua D., Cabello, Christopher M., Qiao, Shuxi, Wondrak, Georg T.

“…Endogenous UVA chromophores may act as sensitizers of oxidative stress underlying cutaneous photoaging and photocarcinogenesis, but the molecular identity of…”
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Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo by Tao, Shasha, Zheng, Yi, Lau, Alexandria, Jaramillo, Melba C, Chau, Binh T, Lantz, R Clark, Wong, Pak K, Wondrak, Georg T, Zhang, Donna D

“…The NF-E2 p45-related factor 2 (Nrf2) signaling pathway regulates the cellular antioxidant response and activation of Nrf2 has recently been shown to limit…”
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Chemoenzymatic Halocyclization of 4‑Pentenoic Acid at Preparative Scale by Höfler, Georg T, But, Andrada, Younes, Sabry H. H, Wever, Ron, Paul, Caroline E, Arends, Isabel W. C. E, Hollmann, Frank

“…The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale…”
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Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner by Tao, Shasha, Rojo de la Vega, Montserrat, Quijada, Hector, Wondrak, Georg T., Wang, Ting, Garcia, Joe G. N., Zhang, Donna D.

“…Mechanical ventilation (MV) is a therapeutic intervention widely used in the clinic to assist patients that have difficulty breathing due to lung edema,…”
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The Drinking Water and Swimming Pool Disinfectant Trichloroisocyanuric Acid Causes Chlorination Stress Enhancing Solar UV‐Induced Inflammatory Gene Expression in AP‐1 Transgenic SKH‐1 Luciferase Reporter Mouse Skin by Snell, Jeremy A., Vaishampayan, Prajakta, Dickinson, Sally E., Jandova, Jana, Wondrak, Georg T.

“…Freshwater sanitation and disinfection using a variety of chemical entities as chlorination agents is an essential public health intervention ensuring water…”
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