Search Results - "Georg, N."

Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation by Huebsch, Nathaniel, Lippens, Evi, Lee, Kangwon, Mehta, Manav, Koshy, Sandeep T., Darnell, Max C., Desai, Rajiv M., Madl, Christopher M., Xu, Maria, Zhao, Xuanhe, Chaudhuri, Ovijit, Verbeke, Catia, Kim, Woo Seob, Alim, Karen, Mammoto, Akiko, Ingber, Donald E., Duda, Georg N., Mooney, David J.

“…The effectiveness of stem cell therapies has been hampered by cell death and limited control over fate. These problems can be partially circumvented by using…”
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The decisive early phase of bone regeneration by Duda, Georg N., Geissler, Sven, Checa, Sara, Tsitsilonis, Serafeim, Petersen, Ansgar, Schmidt-Bleek, Katharina

“…Bone has a remarkable endogenous regenerative capacity that enables scarless healing and restoration of its prior mechanical function, even under challenging…”
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The multifaceted roles of macrophages in bone regeneration: A story of polarization, activation and time by Schlundt, Claudia, Fischer, Heilwig, Bucher, Christian H., Rendenbach, Carsten, Duda, Georg N., Schmidt-Bleek, Katharina

“…To present knowledge, macrophages are found in all tissues of the human body. They are a cell population with high plasticity which come with a multitude of…”
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Towards multi-dynamic mechano-biological optimization of 3D-printed scaffolds to foster bone regeneration by Metz, Camille, Duda, Georg N., Checa, Sara

“…Substantial tissue loss, such as in large bone defects, represents a clinical challenge for which regenerative therapies and tissue engineering strategies aim…”
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Biomaterials that promote cell-cell interactions enhance the paracrine function of MSCs by Qazi, Taimoor H, Mooney, David J, Duda, Georg N, Geissler, Sven

“…Abstract Mesenchymal stromal cells (MSCs) secrete paracrine factors that play crucial roles during tissue regeneration. Whether this paracrine function is…”
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Biomaterial delivery of morphogens to mimic the natural healing cascade in bone by Mehta, Manav, Schmidt-Bleek, Katharina, Duda, Georg N., Mooney, David J.

“…Complications in treatment of large bone defects using bone grafting still remain. Our understanding of the endogenous bone regeneration cascade has inspired…”
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The Metabolic Microenvironment Steers Bone Tissue Regeneration by Loeffler, Julia, Duda, Georg N., Sass, F. Andrea, Dienelt, Anke

“…Over the past years, basic findings in cancer research have revealed metabolic symbiosis between different cell types to cope with high energy demands under…”
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Enzymatically-degradable alginate hydrogels promote cell spreading and in vivo tissue infiltration by Lueckgen, Aline, Garske, Daniela S., Ellinghaus, Agnes, Mooney, David J., Duda, Georg N., Cipitria, Amaia

“…Enzymatically-degradable materials recapitulate the dynamic and reciprocal interactions between cells and their native microenvironment by allowing cells to…”
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Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells by Geissler, Sven, Textor, Martin, Kühnisch, Jirko, Könnig, Delia, Klein, Oliver, Ode, Andrea, Pfitzner, Tilman, Adjaye, James, Kasper, Grit, Duda, Georg N

“…Mesenchymal stromal cells (MSCs) are of high relevance for the regeneration of mesenchymal tissues such as bone and cartilage. The promising role of MSCs in…”
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Hydrogels with tunable stress relaxation regulate stem cell fate and activity by Chaudhuri, Ovijit, Gu, Luo, Klumpers, Darinka, Darnell, Max, Bencherif, Sidi A., Weaver, James C., Huebsch, Nathaniel, Lee, Hong-pyo, Lippens, Evi, Duda, Georg N., Mooney, David J.

“…Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation. However, hydrogels used as synthetic ECMs for three-dimensional (3D)…”
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Niche-mimicking interactions in peptide-functionalized 3D hydrogels amplify mesenchymal stromal cell paracrine effects by Qazi, Taimoor H., Mooney, David J., Duda, Georg N., Geissler, Sven

“…Cells encounter complex environments in vivo where they interact with the extracellular matrix, neighboring cells, and soluble cues, which together influence…”
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Mechanobiologically optimized 3D titanium-mesh scaffolds enhance bone regeneration in critical segmental defects in sheep by Pobloth, Anne-Marie, Checa, Sara, Razi, Hajar, Petersen, Ansgar, Weaver, James C, Schmidt-Bleek, Katharina, Windolf, Markus, Tatai, Andras Á, Roth, Claudia P, Schaser, Klaus-Dieter, Duda, Georg N, Schwabe, Philipp

“…Three-dimensional (3D) titanium-mesh scaffolds offer many advantages over autologous bone grafting for the regeneration of challenging large segmental bone…”
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Biologic-free mechanically induced muscle regeneration by Cezar, Christine A., Roche, Ellen T., Vandenburgh, Herman H., Duda, Georg N., Walsh, Conor J., Mooney, David J.

“…Severe skeletal muscle injuries are common and can lead to extensive fibrosis, scarring, and loss of function. Clinically, no therapeutic intervention exists…”
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Strain shielding inspired re‐design of proximal femoral stems for total hip arthroplasty by Cilla, Myriam, Checa, Sara, Duda, Georg N.

“…ABSTRACT A large number of hip prosthesis with different designs have been developed. However, the influence of hip implant design changes on the strains…”
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Macrophages in bone fracture healing: Their essential role in endochondral ossification by Schlundt, Claudia, El Khassawna, Thaqif, Serra, Alessandro, Dienelt, Anke, Wendler, Sebastian, Schell, Hanna, van Rooijen, Nico, Radbruch, Andreas, Lucius, Richard, Hartmann, Susanne, Duda, Georg N, Schmidt-Bleek, Katharina

“…Abstract In fracture healing, skeletal and immune system are closely interacting through common cell precursors and molecular mediators. It is thought that the…”
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OMIBONE: Omics-driven computer model of bone regeneration for personalized treatment by Jaber, Mahdi, Schmidt, Johannes, Kalkhof, Stefan, Gerstenfeld, Louis, Duda, Georg N., Checa, Sara

“…Treatment of bone fractures are standardized according to the AO classification, which mainly refers to the mechanical stabilization required in a given…”
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Scaffold geometry modulation of mechanotransduction and its influence on epigenetics by Han, Pingping, Gomez, Guillermo A, Duda, Georg N., Ivanovski, Sašo, Poh, Patrina S.P.

“…The dynamics of cell mechanics and epigenetic signatures direct cell behaviour and fate, thus influencing regenerative outcomes. In recent years, the…”
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Aging Leads to a Dysregulation in Mechanically Driven Bone Formation and Resorption by Razi, Hajar, Birkhold, Annette I, Weinkamer, Richard, Duda, Georg N, Willie, Bettina M, Checa, Sara

“…ABSTRACT Physical activity is essential to maintain skeletal mass and structure, but its effect seems to diminish with age. To test the hypothesis that bone…”
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Cell therapy to improve regeneration of skeletal muscle injuries by Qazi, Taimoor H., Duda, Georg N., Ort, Melanie J., Perka, Carsten, Geissler, Sven, Winkler, Tobias

“…Diseases that jeopardize the musculoskeletal system and cause chronic impairment are prevalent throughout the Western world. In Germany alone, ~1.8 million…”
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Road crossing decisions in real and virtual environments: A comparative study on simulator validity by Feldstein, Ilja T., Dyszak, Georg N.

“…•Human perception and behavior in virtual environments may differ from those in real environments.•A novel and simple road crossing assessment method may…”
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