Search Results - "Georas, S N"

T-helper cell type-2 regulation in allergic disease by Georas, S. N, Guo, J, De Fanis, U, Casolaro, V

“…Substantial experimental evidence now supports the notion that allergic diseases are characterised by a skewing of the immune system towards a T-helper cell…”
Get full text

Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge by Georas, S. N., Berdyshev, E., Hubbard, W., Gorshkova, I. A., Usatyuk, P. V., Saatian, B., Myers, A. C., Williams, M. A., Xiao, H. Q., Liu, M., Natarajan, V.

“…Summary Background Lysophosphatidic acid (LPA) is a biologically active lysophospholipid and a component of normal plasma. LPA binds to receptors expressed on…”
Get full text

What is hypoxia‐inducible factor‐1 doing in the allergic lung? by Rangasamy, T., Semenza, G. L., Georas, S. N.

Get full text

Interleukin-13 Upregulates Eotaxin Expression in Airway Epithelial Cells by a STAT6-Dependent Mechanism by Matsukura, Satoshi, Stellato, Cristiana, Georas, Steve N, Casolaro, Vincenzo, Plitt, James R, Miura, Katsushi, Kurosawa, Shin, Schindler, Ulrike, Schleimer, Robert P

“…Interleukin (IL)-13 is a T helper 2-derived cytokine that has recently been implicated in allergic airway responses. We hypothesized that IL-13 may regulate…”
Get full text

Assessment of signal transducer and activator of transcription 6 as a target of glucocorticoid action in human airway epithelial cells by Heller, N. M., Matsukura, S., Georas, S. N., Boothby, M. R., Stellato, C., Schleimer, R. P.

“…Summary Background Activation of signal transducer and activator of transcription (STAT)6 by IL‐4 and IL‐13 is essential in many key epithelial responses in…”
Get full text

Eosinophil transendothelial migration induced by cytokines. I. Role of endothelial and eosinophil adhesion molecules in IL-1 beta-induced transendothelial migration by Ebisawa, M, Bochner, BS, Georas, SN, Schleimer, RP

“…IL-1 beta promotes adhesiveness in human umbilical vein endothelial cells (HuVEC) for eosinophils through expression of adhesion molecules including…”
Get full text

Altered adhesion molecule expression and endothelial cell activation accompany the recruitment of human granulocytes to the lung after segmental antigen challenge by Georas, S N, Liu, M C, Newman, W, Beall, L D, Stealey, B A, Bochner, B S

“…Mounting evidence suggests that inflammatory cells recruited to the lung can contribute to the pathogenesis of asthma. The factors governing the activation and…”
Get more information

Inhibition of NF-AT-Dependent Transcription by NF-κB: Implications for Differential Gene Expression in T Helper Cell Subsets by Casolaro, Vincenzo, Georas, Steve N., Song, Zhimin, Zubkoff, Ira D., Abdulkadir, Sarki A., Thanos, Dimitris, Ono, Santa Jeremy

“…Activation of individual CD4+T cells results in differential lymphokine expression: interleukin 2 (IL-2) is preferentially produced by T helper type 1 (TH1)…”
Get full text

Analysis of CD4+ T-cell gene expression in allergic subjects using two different microarray platforms by Hansel, N.N, Cheadle, C, Diette, G.B, Wright, J, Thompson, K.M, Barnes, K.C, Georas, S.N

“…Allergic diseases are thought to involve dysregulated activation of T cells including CD4+ lymphocytes. T-cell activation results in changes in gene…”
Get full text

Preferential Activation of Nuclear Factor of Activated T Cells c Correlates with Mouse Strain Susceptibility to Allergic Responses and Interleukin-4 Gene Expression by Keen, Judith Clancy, Sholl, Lynette, Wills-Karp, Marsha, Georas, Steve N

“…Dysregulated expression of the T helper 2 cytokine interleukin (IL)-4 is thought to play a fundamental role in the pathogenesis of allergic asthma. The…”
Get full text

Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells by Saatian, Bahman, Zhao, Yutong, He, Donghong, Georas, Steve N, Watkins, Tonya, Spannhake, Ernst Wm, Natarajan, Viswanathan

“…HBEpCs (human bronchial epithelial cells) contribute to airway inflammation by secreting a variety of cytokines and chemokines in response to allergens,…”
Get full text

AMP-Activated Kinase Regulates Cytoplasmic HuR by Wang, Wengong, Fan, Jinshui, Yang, Xiaoling, Fürer-Galban, Stefanie, Lopez de Silanes, Isabel, von Kobbe, Cayetano, Guo, Jia, Georas, Steve N., Foufelle, Fabienne, Hardie, D. Grahame, Carling, David, Gorospe, Myriam

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells by Matsukura, S, Stellato, C, Plitt, J R, Bickel, C, Miura, K, Georas, S N, Casolaro, V, Schleimer, R P

“…The C-C chemokine eotaxin is a potent chemoattractant for eosinophils and probably plays an important role in the pathogenesis of asthma, although the…”
Get full text

Expression of a functional laminin receptor (α6β1, very late activation antigen-6) on human eosinophils by GEORAS, S. N, MCINTYRE, B. W, EBISAWA, M, BEDNARCZYK, J. L, STERBINSKY, S. A, SCHLEIMER, R. P, BOCHNER, B. S

“…The mechanisms responsible for the accumulation of eosinophils at sites of allergic and other inflammatory reactions are unknown, but recent studies have…”
Get full text

Pulmonary infiltrates after cytokine therapy for stem cell transplantation : Massive deposition of eosinophil major basic protein detected by immunohistochemistry by O'HEARN, D. J, LEIFERMAN, K. M, ASKIN, F, GEORAS, S. N

“…Interleukin-2 (IL-2), a product of activated T-cells, is now being used in a number of protocols for cancer immunotherapy. In one stem cell transplantation…”
Get full text

Selective inhibition of interleukin-4 gene expression in human T cells by aspirin by Cianferoni, Antonella, Schroeder, John T., Kim, Jean, Schmidt, John W., Lichtenstein, Lawrence M., Georas, Steve N., Casolaro, Vincenzo

“…Previous studies indicated that aspirin (acetylsalicylic acid [ASA]) can have profound immunomodulatory effects by regulating cytokine gene expression in…”
Get full text

Histone deacetylation inhibits IL4 gene expression in T cells by Valapour, Maryam, Guo, Jia, Schroeder, John T., Keen, Judith, Cianferoni, Antonella, Casolaro, Vincenzo, Georas, Steve N.

“…Background: Dysregulated expression of IL-4 has been linked with allergic diseases. IL-4 expression is controlled at the level of gene transcription by the…”
Get full text

Cutaneous injection of human subjects with macrophage inflammatory protein-1 alpha induces significant recruitment of neutrophils and monocytes by Lee, S C, Brummet, M E, Shahabuddin, S, Woodworth, T G, Georas, S N, Leiferman, K M, Gilman, S C, Stellato, C, Gladue, R P, Schleimer, R P, Beck, L A

“…Macrophage inflammatory protein (MIP-1 alpha), a member of the CC chemokine subfamily, has been shown to attract T cells and monocytes in vitro and to be…”
Get full text

Yin-Yang 1 Activates Interleukin-4 Gene Expression in T Cells by Guo, Jia, Casolaro, Vincenzo, Seto, Edward, Yang, Wen-Ming, Chang, Cindy, Seminario, Maria-Cristina, Keen, Judith, Georas, Steve N.

“…Interleukin-4 (IL-4) is a multifunctional cytokine that plays an important role in immune and inflammatory responses. Expression of the IL-4 gene is tightly…”
Get full text

Polymorphic nucleotides within the human IL-4 promoter that mediate overexpression of the gene by Song, Z, Casolaro, V, Chen, R, Georas, SN, Monos, D, Ono, SJ

“…Atopy, which predisposes individuals to develop asthma, severe systemic anaphylaxis, and atopic dermatitis, is usually associated with dramatically elevated…”
Get full text