Search Results - "Geoghegan, Niall D."

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis by McArthur, Kate, Whitehead, Lachlan W, Heddleston, John M, Li, Lucy, Padman, Benjamin S, Oorschot, Viola, Geoghegan, Niall D, Chappaz, Stephane, Davidson, Sophia, San Chin, Hui, Lane, Rachael M, Dramicanin, Marija, Saunders, Tahnee L, Sugiana, Canny, Lessene, Romina, Osellame, Laura D, Chew, Teng-Leong, Dewson, Grant, Lazarou, Michael, Ramm, Georg, Lessene, Guillaume, Ryan, Michael T, Rogers, Kelly L, van Delft, Mark F, Kile, Benjamin T

“…Mitochondrial apoptosis is mediated by BAK and BAX, two proteins that induce mitochondrial outer membrane permeabilization, leading to cytochrome c release and…”
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MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis by Samson, Andre L., Zhang, Ying, Geoghegan, Niall D., Gavin, Xavier J., Davies, Katherine A., Mlodzianoski, Michael J., Whitehead, Lachlan W., Frank, Daniel, Garnish, Sarah E., Fitzgibbon, Cheree, Hempel, Anne, Young, Samuel N., Jacobsen, Annette V., Cawthorne, Wayne, Petrie, Emma J., Faux, Maree C., Shield-Artin, Kristy, Lalaoui, Najoua, Hildebrand, Joanne M., Silke, John, Rogers, Kelly L., Lessene, Guillaume, Hawkins, Edwin D., Murphy, James M.

“…Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is…”
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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Apicobasal RNA asymmetries regulate cell fate in the early mouse embryo by Hawdon, Azelle, Geoghegan, Niall D., Mohenska, Monika, Elsenhans, Anja, Ferguson, Charles, Polo, Jose M., Parton, Robert G., Zenker, Jennifer

“…The spatial sorting of RNA transcripts is fundamental for the refinement of gene expression to distinct subcellular regions. Although, in non-mammalian early…”
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4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation by Geoghegan, Niall D., Evelyn, Cindy, Whitehead, Lachlan W., Pasternak, Michal, McDonald, Phoebe, Triglia, Tony, Marapana, Danushka S., Kempe, Daryan, Thompson, Jennifer K., Mlodzianoski, Michael J., Healer, Julie, Biro, Maté, Cowman, Alan F., Rogers, Kelly L.

“…Host membrane remodeling is indispensable for viruses, bacteria, and parasites, to subvert the membrane barrier and obtain entry into cells. The malaria…”
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Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1 by Dans, Madeline G., Boulet, Coralie, Watson, Gabrielle M., Nguyen, William, Dziekan, Jerzy M., Evelyn, Cindy, Reaksudsan, Kitsanapong, Mehra, Somya, Razook, Zahra, Geoghegan, Niall D., Mlodzianoski, Michael J., Goodman, Christopher Dean, Ling, Dawson B., Jonsdottir, Thorey K., Tong, Joshua, Famodimu, Mufuliat Toyin, Kristan, Mojca, Pollard, Harry, Stewart, Lindsay B., Brandner-Garrod, Luke, Sutherland, Colin J., Delves, Michael J., McFadden, Geoffrey I., Barry, Alyssa E., Crabb, Brendan S., de Koning-Ward, Tania F., Rogers, Kelly L., Cowman, Alan F., Tham, Wai-Hong, Sleebs, Brad E., Gilson, Paul R.

“…With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833…”
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Author Correction: Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1 by Dans, Madeline G., Boulet, Coralie, Watson, Gabrielle M., Nguyen, William, Dziekan, Jerzy M., Evelyn, Cindy, Reaksudsan, Kitsanapong, Mehra, Somya, Razook, Zahra, Geoghegan, Niall D., Mlodzianoski, Michael J., Goodman, Christopher Dean, Ling, Dawson B., Jonsdottir, Thorey K., Tong, Joshua, Famodimu, Mufuliat Toyin, Kristan, Mojca, Pollard, Harry, Stewart, Lindsay B., Brandner-Garrod, Luke, Sutherland, Colin J., Delves, Michael J., McFadden, Geoffrey I., Barry, Alyssa E., Crabb, Brendan S., de Koning-Ward, Tania F., Rogers, Kelly L., Cowman, Alan F., Tham, Wai-Hong, Sleebs, Brad E., Gilson, Paul R.

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In situ visualization of endothelial cell-derived extracellular vesicle formation in steady state and malignant conditions by Atkin-Smith, Georgia K., Santavanond, Jascinta P., Light, Amanda, Rimes, Joel S., Samson, Andre L., Er, Jeremy, Liu, Joy, Johnson, Darryl N., Le Page, Mélanie, Rajasekhar, Pradeep, Yip, Raymond K. H., Geoghegan, Niall D., Rogers, Kelly L., Chang, Catherine, Bryant, Vanessa L., Margetts, Mai, Keightley, M. Cristina, Kilpatrick, Trevor J., Binder, Michele D., Tran, Sharon, Lee, Erinna F., Fairlie, Walter D., Ozkocak, Dilara C., Wei, Andrew H., Hawkins, Edwin D., Poon, Ivan K. H.

“…Endothelial cells are integral components of all vasculature within complex organisms. As they line the blood vessel wall, endothelial cells are constantly…”
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Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes by Morris, Silke, Geoghegan, Niall D, Sadler, Jessica B A, Koester, Anna M, Black, Hannah L, Laub, Marco, Miller, Lucy, Heffernan, Linda, Simpson, Jeremy C, Mastick, Cynthia C, Cooper, Jon, Gadegaard, Nikolaj, Bryant, Nia J, Gould, Gwyn W

“…Insulin-stimulated glucose transport is a characteristic property of adipocytes and muscle cells and involves the regulated delivery of glucose transporter…”
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Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion by Liang, Lung-Yu, Geoghegan, Niall D., Mlodzianoski, Michael, Leis, Andrew, Whitehead, Lachlan W., Surudoi, Minglyanna G., Young, Samuel N., Janes, Peter, Shepherd, Doulin, Ghosal, Debnath, Rogers, Kelly L., Murphy, James M., Lucet, Isabelle S.

“…EphB6 is an understudied ephrin receptor tyrosine pseudokinase that is downregulated in multiple types of metastatic cancers. Unlike its kinase-active…”
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Activation mechanism of PINK1 by Gan, Zhong Yan, Callegari, Sylvie, Cobbold, Simon A., Cotton, Thomas R., Mlodzianoski, Michael J., Schubert, Alexander F., Geoghegan, Niall D., Rogers, Kelly L., Leis, Andrew, Dewson, Grant, Glukhova, Alisa, Komander, David

“…Mutations in the protein kinase PINK1 lead to defects in mitophagy and cause autosomal recessive early onset Parkinson’s disease 1 , 2 . PINK1 has many unique…”
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Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors by Dent, Michael R, López-Duarte, Ismael, Dickson, Callum J, Geoghegan, Niall D, Cooper, Jonathan M, Gould, Ian R, Krams, Rob, Bull, James A, Brooks, Nicholas J, Kuimova, Marina K

“…In order to fully understand the dynamics of processes within biological lipid membranes, it is necessary to possess an intimate knowledge of the physical…”
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Increasing histone acetylation improves sociability and restores learning and memory in KAT6B-haploinsufficient mice by Bergamasco, Maria I, Vanyai, Hannah K, Garnham, Alexandra L, Geoghegan, Niall D, Vogel, Adam P, Eccles, Samantha, Rogers, Kelly L, Smyth, Gordon K, Blewitt, Marnie E, Hannan, Anthony J, Thomas, Tim, Voss, Anne K

“…Mutations in genes encoding chromatin modifiers are enriched among mutations causing intellectual disability. The continuing development of the brain…”
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The reinvention of twentieth century microscopy for three‐dimensional imaging by Whitehead, Lachlan W, McArthur, Kate, Geoghegan, Niall D, Rogers, Kelly L

“…In just over a decade, the field of biomedical research has witnessed a radical evolution in technologies for the 3‐ and 4‐dimensional imaging of biological…”
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Publisher Correction: Activation mechanism of PINK1 by Gan, Zhong Yan, Callegari, Sylvie, Cobbold, Simon A., Cotton, Thomas R., Mlodzianoski, Michael J., Schubert, Alexander F., Geoghegan, Niall D., Rogers, Kelly L., Leis, Andrew, Dewson, Grant, Glukhova, Alisa, Komander, David

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Sulfonylpiperazine compounds prevent Plasmodium falciparum invasion of red blood cells through interference with actin-1/profilin dynamics by Dans, Madeline G, Piirainen, Henni, Nguyen, William, Khurana, Sachin, Mehra, Somya, Razook, Zahra, Geoghegan, Niall D, Dawson, Aurelie T, Das, Sujaan, Parkyn Schneider, Molly, Jonsdottir, Thorey K, Gabriela, Mikha, Gancheva, Maria R, Tonkin, Christopher J, Mollard, Vanessa, Goodman, Christopher Dean, McFadden, Geoffrey I, Wilson, Danny W, Rogers, Kelly L, Barry, Alyssa E, Crabb, Brendan S, de Koning-Ward, Tania F, Sleebs, Brad E, Kursula, Inari, Gilson, Paul R

“…With emerging resistance to frontline treatments, it is vital that new antimalarial drugs are identified to target Plasmodium falciparum. We have recently…”
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PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum by Scally, Stephen W., Triglia, Tony, Evelyn, Cindy, Seager, Benjamin A., Pasternak, Michał, Lim, Pailene S., Healer, Julie, Geoghegan, Niall D., Adair, Amy, Tham, Wai-Hong, Dagley, Laura F., Rogers, Kelly L., Cowman, Alan F.

“…The most severe form of malaria is caused by Plasmodium falciparum . These parasites invade human erythrocytes, and an essential step in this process involves…”
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Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24 by Davidson, Sophia, Yu, Chien-Hsiung, Steiner, Annemarie, Ebstein, Frédéric, Baker, Paul J, Jarur-Chamy, Valentina, Hrovat Schaale, Katja, Laohamonthonkul, Pawat, Kong, Klara, Calleja, Dale J, Harapas, Cassandra R, Balka, Katherine R, Mitchell, Jacob, Jackson, Jacob T, Geoghegan, Niall D, Moghaddas, Fiona, Rogers, Kelly L, Mayer-Barber, Katrin D, De Jesus, Adriana A, De Nardo, Dominic, Kile, Benjamin T, Sadler, Anthony J, Poli, M Cecilia, Krüger, Elke, Goldbach Mansky, Raphaela, Masters, Seth L

“…Proteasome dysfunction can lead to autoinflammatory disease associated with elevated type I interferon (IFN-αβ) and NF-κB signaling; however, the innate immune…”
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Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein Pf START1 by Dans, Madeline G., Boulet, Coralie, Watson, Gabrielle M., Nguyen, William, Dziekan, Jerzy M., Evelyn, Cindy, Reaksudsan, Kitsanapong, Mehra, Somya, Razook, Zahra, Geoghegan, Niall D., Mlodzianoski, Michael J., Goodman, Christopher Dean, Ling, Dawson B., Jonsdottir, Thorey K., Tong, Joshua, Famodimu, Mufuliat Toyin, Kristan, Mojca, Pollard, Harry, Stewart, Lindsay B., Brandner-Garrod, Luke, Sutherland, Colin J., Delves, Michael J., McFadden, Geoffrey I., Barry, Alyssa E., Crabb, Brendan S., de Koning-Ward, Tania F., Rogers, Kelly L., Cowman, Alan F., Tham, Wai-Hong, Sleebs, Brad E., Gilson, Paul R.

“…With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833…”
Get full text