Search Results - "Geoffroy, Cédric G"

Myelin-associated inhibitors in axonal growth after CNS injury by Geoffroy, Cédric G, Zheng, Binhai

“…Highlights • Regeneration and sprouting are two forms of injury-induced axonal growth. • Myelin inhibitors modulate axonal sprouting after CNS injury. •…”
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Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System by Geoffroy, Cédric G., Hilton, Brett J., Tetzlaff, Wolfram, Zheng, Binhai

“…How aging impacts axon regeneration after CNS injury is not known. We assessed the impact of age on axon regeneration induced by Pten deletion in corticospinal…”
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NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans by Dickendesher, Travis L, Baldwin, Katherine T, Mironova, Yevgeniya A, Koriyama, Yoshiki, Raiker, Stephen J, Askew, Kim L, Wood, Andrew, Geoffroy, Cédric G, Zheng, Binhai, Liepmann, Claire D, Katagiri, Yasuhiro, Benowitz, Larry I, Geller, Herbert M, Giger, Roman J

“…In this study, the authors show that NgR1 and NgR3 can act as functional receptors for chondroitin sulfate proteoglycans (CSPGs), mediating inhibition of…”
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The Potential Role of Inflammation in Modulating Endogenous Hippocampal Neurogenesis After Spinal Cord Injury by Sefiani, Arthur, Geoffroy, Cédric G.

“…Currently there are approximately 291,000 people suffering from a spinal cord injury (SCI) in the United States. SCI is associated with traumatic changes in…”
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Novel adult cortical neuron processing and screening method illustrates sex- and age-dependent effects of pharmaceutical compounds by Sefiani, Arthur, Rusyn, Ivan, Geoffroy, Cédric G.

“…Neurodegenerative diseases and neurotraumatic injuries are typically age-associated disorders that can reduce neuron survival, neurite outgrowth, and synaptic…”
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Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice by Geoffroy, Cédric G, Lorenzana, Ariana O, Kwan, Jeffrey P, Lin, Kyle, Ghassemi, Omeed, Ma, Andrew, Xu, Nuo, Creger, Daniel, Liu, Kai, He, Zhigang, Zheng, Binhai

“…Axons in the adult CNS have poor ability to grow after injury, impeding functional recovery in patients of spinal cord injury. This has been attributed to both…”
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Assessing Spinal Axon Regeneration and Sprouting in Nogo-, MAG-, and OMgp-Deficient Mice by Lee, Jae K., Geoffroy, Cédric G., Chan, Andrea F., Tolentino, Kristine E., Crawford, Michael J., Leal, Marisa A., Kang, Brian, Zheng, Binhai

“…A central hypothesis for the limited capacity for adult central nervous system (CNS) axons to regenerate is the presence of myelin-derived axon growth…”
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Selective, Intrinsically Fluorescent Trk Modulating Probes by Pewklang, Thitima, Thompson, Tye, Sefiani, Arthur, Geoffroy, Cédric G., Kamkaew, Anyanee, Burgess, Kevin

“…Neurotrophins (NTs) elicit the growth, survival, and differentiation of neurons and other neuroectoderm tissues via activation of Trk receptors. Hot spots for…”
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The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms by Geoffroy, Cédric G., Meves, Jessica M., Zheng, Binhai

“…Age is an important consideration for recovery and repair after spinal cord injury. Spinal cord injury is increasingly affecting the middle-aged and aging…”
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Neuronal ablation of GHSR mitigates diet-induced depression and memory impairment via AMPK-autophagy signaling-mediated inflammation by Wang, Hongying, Shen, Zheng, Wu, Chia-Shan, Ji, Pengfei, Noh, Ji Yeon, Geoffroy, Cédric G, Kim, Sunja, Threadgill, David, Li, Jianrong, Zhou, Yu, Xiao, Xiaoqiu, Zheng, Hui, Sun, Yuxiang

“…Obesity is associated with chronic inflammation in the central nervous system (CNS), and neuroinflammation has been shown to have detrimental effects on mood…”
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The Influence of Neuron-Extrinsic Factors and Aging on Injury Progression and Axonal Repair in the Central Nervous System by Sutherland, Theresa C, Geoffroy, Cédric G

“…In the aging western population, the average age of incidence for spinal cord injury (SCI) has increased, as has the length of survival of SCI patients. This…”
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Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS by Chen, Meifan, Geoffroy, Cédric G., Meves, Jessica M., Narang, Aarti, Li, Yunbo, Nguyen, Mallorie T., Khai, Vung S., Kong, Xiangmei, Steinke, Christopher L., Carolino, Krislyn I., Elzière, Lucie, Goldberg, Mark P., Jin, Yishi, Zheng, Binhai

“…Reactive astrocytes influence post-injury recovery, repair, and pathogenesis of the mammalian CNS. Much of the regulation of astrocyte reactivity, however,…”
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Oligodendrocytic but not neuronal Nogo restricts corticospinal axon sprouting after CNS injury by Meves, Jessica M., Geoffroy, Cédric G., Kim, Noah D., Kim, Joseph J., Zheng, Binhai

“…Recovery from injury to the central nervous system (CNS) is limited in the mammalian adult. Nonetheless, some degree of spontaneous recovery occurs after…”
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Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons by Chen, Meifan, Geoffroy, Cédric G., Wong, Hetty N., Tress, Oliver, Nguyen, Mallorie T., Holzman, Lawrence B., Jin, Yishi, Zheng, Binhai

“…Leucine Zipper-bearing Kinase (LZK/MAP3K13) is a member of the mixed lineage kinase family with high sequence identity to Dual Leucine Zipper Kinase…”
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A novel Oct4/Pou5f1-like non-coding RNA controls neural maturation and mediates developmental effects of ethanol by Salem, Nihal A., Mahnke, Amanda H., Tseng, Alexander M., Garcia, Cadianna R., Jahromi, Hooman K., Geoffroy, Cédric G., Miranda, Rajesh C.

“…Prenatal ethanol exposure can result in loss of neural stem cells (NSCs) and decreased brain growth. Here, we assessed whether a noncoding RNA (ncRNA) related…”
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In vivo peptide-based delivery of a gene-modifying enzyme into cells of the central nervous system by Allen, Jason K., Sutherland, Theresa C., Prater, Austin R., Geoffroy, Cédric G., Pellois, Jean-Philippe

“…We report on the successful delivery of the Cre recombinase enzyme in the neural cells of mice in vivo by simple coinjection with peptides derived from…”
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Osteopenia in a Mouse Model of Spinal Cord Injury: Effects of Age, Sex and Motor Function by Hook, Michelle A, Falck, Alyssa, Dundumulla, Ravali, Terminel, Mabel, Cunningham, Rachel, Sefiani, Arthur, Callaway, Kayla, Gaddy, Dana, Geoffroy, Cédric G

“…After spinal cord injury (SCI), 80% of individuals are diagnosed with osteopenia or osteoporosis. The dramatic loss of bone after SCI increases the potential…”
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Age-Dependent Decline in Neuron Growth Potential and Mitochondria Functions in Cortical Neurons by Sutherland, Theresa C, Sefiani, Arthur, Horvat, Darijana, Huntington, Taylor E, Lei, Yuanjiu, West, A Phillip, Geoffroy, Cédric G

“…The age of incidence of spinal cord injury (SCI) and the average age of people living with SCI is continuously increasing. However, SCI is extensively modeled…”
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Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting by Geoffroy, Cédric G., Meves, Jessica M., Kim, Hugo Jae Mun, Romaus-Sanjurjo, Daniel, Sutherland, Theresa C., Li, Jeffrey J., Suen, Juliet, Sanchez, Joshua J., Zheng, Binhai

“…Axonal repair is critical for functional recovery after injury of the CNS. We previously reported that neuronal PTEN deletion exhibits an age-dependent decline…”
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Are mitochondria the key to reduce the age-dependent decline in axon growth after spinal cord injury? by Sutherland, Theresa, Geoffroy, Cédric

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