Search Results - "Geoffrey W. McCaughan"

Alcoholic Liver Disease in Asia, Europe, and North America by Liangpunsakul, Suthat, Haber, Paul, McCaughan, Geoff

“…Alcoholic liver diseases comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from…”
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COVID‐19 and comorbidities: A role for dipeptidyl peptidase 4 (DPP4) in disease severity? by Bassendine, Margaret F., Bridge, Simon H., McCaughan, Geoffrey W., Gorrell, Mark D.

“…The coronavirus disease 2019 (COVID‐19) pandemic is caused by a novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), similar to…”
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Current perspectives on the tumor microenvironment in hepatocellular carcinoma by Santhakumar, Cositha, Gane, Edward J., Liu, Ken, McCaughan, Geoffrey W.

“…Hepatocellular carcinoma (HCC) is a heterogeneous inflammation-driven malignancy, which, despite significant advances in management, continues to portend a…”
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Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma by Vongsuvanh, Roslyn, van der Poorten, David, Iseli, Tristan, Strasser, Simone I, McCaughan, Geoffrey W, George, Jacob

“…Robust biomarkers for population-level hepatocellular carcinoma (HCC) surveillance are lacking. We compared serum midkine (MDK), dickkopf-1 (DKK1), osteopontin…”
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Frailty in advanced liver disease by Laube, Robyn, Wang, Hogan, Park, Laura, Heyman, Joanne K., Vidot, Helen, Majumdar, Avik, Strasser, Simone I., McCaughan, Geoffrey W., Liu, Ken

“…Prognostication of patients with cirrhosis is complex, depending on more than just the severity of liver disease. Scores such as the model for end‐stage liver…”
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Immunotherapy for hepatocellular carcinoma: recent advances and future perspectives by Xu, Weiqi, Liu, Ken, Chen, Minjiang, Sun, Jin-Yu, McCaughan, Geoffrey W, Lu, Xiao-Jie, Ji, Jiansong

“…The introduction of immunotherapies has been a major development in the treatment of many advanced cancers, including hepatocellular carcinoma (HCC). We are…”
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A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs by English, Kieran, Kwan, Rain, Holz, Lauren E., McGuffog, Claire, Krol, Jelte M. M., Kempe, Daryan, Kaisho, Tsuneyasu, Heath, William R., Lisowski, Leszek, Biro, Maté, McCaughan, Geoffrey W., Bowen, David G., Bertolino, Patrick

“…While CD4 + T cells are a prerequisite for CD8 + T cell-mediated protection against intracellular hepatotropic pathogens, the mechanisms facilitating the…”
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Feasibility of conducting a randomized control trial for liver cancer screening: Is a randomized controlled trial for liver cancer screening feasible or still needed? by Poustchi, Hossein, Farrell, Geoffrey C., Strasser, Simone I., Lee, Alice U., McCaughan, Geoffrey W., George, Jacob

“…Screening for hepatocellular carcinoma (HCC) is commonly practiced and recommended in published guidelines, but evidence for its efficacy has been…”
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APASL HCV guidelines of virus-eradicated patients by DAA on how to monitor HCC occurrence and HBV reactivation by Kanda, Tatsuo, Lau, George K. K., Wei, Lai, Moriyama, Mitsuhiko, Yu, Ming-Lung, Chuang, Wang-Long, Ibrahim, Alaaeldin, Lesmana, Cosmas Rinaldi Adithya, Sollano, Jose, Kumar, Manoj, Jindal, Ankur, Sharma, Barjesh Chander, Hamid, Saeed S., Kadir Dokmeci, A., Mamun-Al-Mahtab, McCaughan, Geoffrey W., Wasim, Jafri, Crawford, Darrell H. G., Kao, Jia-Horng, Ooka, Yoshihiko, Yokosuka, Osamu, Sarin, Shiv Kumar, Omata, Masao

“…In the direct-acting antiviral (DAA) era for hepatitis C virus (HCV) infection, sustained virological response (SVR) is very high, but close attention must be…”
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Induction Phase of Spontaneous Liver Transplant Tolerance by McCaughan, Geoffrey W, Bowen, David G, Bertolino, Patrick J

“…The liver has long been known to possess tolerogenic properties. Early experiments in liver transplantation demonstrated that in animal models, hepatic…”
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Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling by Cochrane, Catherine R, Vaghjiani, Vijesh, Szczepny, Anette, Jayasekara, W Samantha N, Gonzalez-Rajal, Alvaro, Kikuchi, Kazu, McCaughan, Geoffrey W, Burgess, Andrew, Gough, Daniel J, Watkins, D Neil, Cain, Jason E

“…Ligand-dependent activation of Hedgehog (Hh) signaling in cancer occurs without mutations in canonical pathway genes. Consequently, the genetic basis of Hh…”
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The liver contains distinct interconnected networks of CX3CR1+ macrophages, XCR1+ type 1 and CD301a+ type 2 conventional dendritic cells embedded within portal tracts by English, Kieran, Tan, Sioh Yang, Kwan, Rain, Holz, Lauren E, Sierro, Frederic, McGuffog, Claire, Kaisho, Tsuneyasu, Heath, William R, MacDonald, Kelli PA, McCaughan, Geoffrey W, Bowen, David G, Bertolino, Patrick

“…Portal tracts are key intrahepatic structures where leukocytes accumulate during immune responses. They contain the blood inflow, which includes portal blood…”
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Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses by Tay, Szun Szun, Wong, Yik Chun, McDonald, David M, Wood, Nicole A W, Roediger, Ben, Sierro, Frederic, Mcguffog, Claire, Alexander, Ian E, Bishop, G Alex, Gamble, Jennifer R, Weninger, Wolfgang, McCaughan, Geoffrey W, Bertolino, Patrick, Bowen, David G

“…CD8 T-cell responses to liver-expressed antigens range from deletional tolerance to full effector differentiation resulting in overt hepatotoxicity. The…”
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Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation by Cabanes-Creus, Marti, Liao, Sophia H. Y., Gale Navarro, Renina, Knight, Maddison, Nazareth, Deborah, Lau, Ngee-Soon, Ly, Mark, Zhu, Erhua, Roca-Pinilla, Ramon, Bugallo Delgado, Ricardo, Vicente, Ana F., Baltazar, Grober, Westhaus, Adrian, Merjane, Jessica, Crawford, Michael, McCaughan, Geoffrey W., Unzu, Carmen, González-Aseguinolaza, Gloria, Alexander, Ian E., Pulitano, Carlo, Lisowski, Leszek

“…Developing clinically predictive model systems for evaluating gene transfer and gene editing technologies has become increasingly important in the era of…”
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Hepatocyte entry leads to degradation of autoreactive CD8 T cells by Benseler, Volker, Warren, Alessandra, Vo, Michelle, Holz, Lauren E, Tay, Szun S, Le Couteur, David G, Breen, Eamon, Allison, Anthony C, van Rooijen, Nico, McGuffog, Claire, Schlitt, Hans J, Bowen, David G, McCaughan, Geoffrey W, Bertolino, Patrick

“…Although most self-reactive T cells are eliminated in the thymus, mechanisms to inactivate or control T cells specific for extrathymic antigens are required…”
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Novel miRNA-based drug CD5-2 reduces liver tumor growth in diethylnitrosamine-treated mice by normalizing tumor vasculature and altering immune infiltrate by Liu, Ken, Chen, Jinbiao, Zhao, Yang, Boland, Jade, Ting, Ka Ka, Lockwood, Glen, McKenzie, Catriona, Kench, James, Vadas, Mathew A., Gamble, Jennifer R., McCaughan, Geoffrey W.

“…Introduction Liver cancers exhibit abnormal (leaky) vasculature, hypoxia and an immunosuppressive microenvironment. Normalization of tumor vasculature is an…”
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Hepascore: An Accurate Validated Predictor of Liver Fibrosis in Chronic Hepatitis C Infection by Adams, Leon A, Bulsara, Max, Rossi, Enrico, DeBoer, Bastiaan, Speers, David, George, Jacob, Kench, James, Farrell, Geoffrey, McCaughan, Geoffrey W, Jeffrey, Gary P

“…Staging hepatic fibrosis by liver biopsy guides prognosis and treatment of hepatitis C, but is invasive and expensive. We sought to create an algorithm of…”
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Lamivudine Plus Low-Dose Hepatitis B Immunoglobulin to Prevent Recurrent Hepatitis B Following Liver Transplantation by Gane, Edward J, Angus, Peter W, Strasser, Simone, Crawford, Darrell H.G, Ring, John, Jeffrey, Gary P, McCaughan, Geoffrey W

“…Background & Aims: High-dose intravenous hepatitis B immunoglobulin (HBIG) may prevent recurrent hepatitis B virus (HBV) infection, but the cost has limited…”
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dipeptidyl peptidase IV family in cancer and cell biology by Yu, Denise M.T, Yao, Tsun-Wen, Chowdhury, Sumaiya, Nadvi, Naveed A, Osborne, Brenna, Church, W. Bret, McCaughan, Geoffrey W, Gorrell, Mark D

“…Of the 600+ known proteases identified to date in mammals, a significant percentage is involved or implicated in pathogenic and cancer processes. The…”
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Combination of lamivudine and adefovir without hepatitis B immune globulin is safe and effective prophylaxis against hepatitis B virus recurrence in hepatitis B surface antigen–positive liver transplant candidates by Gane, Edward J., Patterson, Scott, Strasser, Simone I., McCaughan, Geoffrey W., Angus, Peter W.

“…Without effective prophylaxis, liver transplantation for hepatitis B virus (HBV)–related liver disease is frequently complicated by severe and rapidly…”
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