Search Results - "Gentleman, Steve M."

Microglial Activation in Traumatic Brain Injury by Donat, Cornelius K, Scott, Gregory, Gentleman, Steve M, Sastre, Magdalena

“…Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and mediating the immune response against peripheral infection…”
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Transmission of multiple system atrophy prions to transgenic mice by Watts, Joel C., Giles, Kurt, Oehler, Abby, Middleton, Lefkos, Dexter, David T., Gentleman, Steve M., DeArmond, Stephen J., Prusiner, Stanley B.

“…Prions are proteins that adopt alternative conformations, which become self-propagating. Increasing evidence argues that prions feature in the…”
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Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer’s and Parkinson’s disease by Liu, Alan King Lun, Chang, Raymond Chuen-Chung, Pearce, Ronald K. B., Gentleman, Steve M.

“…It has been well established that neuronal loss within the cholinergic nucleus basalis of Meynert (nbM) correlates with cognitive decline in dementing…”
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Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism by Prusiner, Stanley B., Woerman, Amanda L., Mordes, Daniel A., Watts, Joel C., Rampersaud, Ryan, Berry, David B., Patel, Smita, Oehler, Abby, Lowe, Jennifer K., Kravitz, Stephanie N., Geschwind, Daniel H., Glidden, David V., Halliday, Glenda M., Middleton, Lefkos T., Gentleman, Steve M., Grinberg, Lea T., Giles, Kurt

“…Prions are proteins that adopt alternative conformations that become self-propagating; the PrPScprion causes the rare human disorder Creutzfeldt–Jakob disease…”
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Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues by Lai, Hei Ming, Liu, Alan King Lun, Ng, Harry Ho Man, Goldfinger, Marc H., Chau, Tsz Wing, DeFelice, John, Tilley, Bension S., Wong, Wai Man, Wu, Wutian, Gentleman, Steve M.

“…Modern clearing techniques for the three-dimensional (3D) visualisation of neural tissue microstructure have been very effective when used on rodent brain but…”
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Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-β Precursor Protein by Parr, Callum, Carzaniga, Raffaela, Gentleman, Steve M., Van Leuven, Fred, Walter, Jochen, Sastre, Magdalena

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Chemical Probes for Visualizing Intact Animal and Human Brain Tissue by Lai, Hei Ming, Ng, Wai-Lung, Gentleman, Steve M, Wu, Wutian

“…Newly developed tissue clearing techniques can be used to render intact tissues transparent. When combined with fluorescent labeling technologies and optical…”
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Propagation of prions causing synucleinopathies in cultured cells by Woerman, Amanda L., Stöhr, Jan, Aoyagi, Atsushi, Rampersaud, Ryan, Krejciova, Zuzana, Watts, Joel C., Ohyama, Takao, Patel, Smita, Widjaja, Kartika, Oehler, Abby, Sanders, David W., Diamond, Marc I., Seeley, William W., Middleton, Lefkos T., Gentleman, Steve M., Mordes, Daniel A., Südhof, Thomas C., Giles, Kurt, Prusiner, Stanley B.

“…Increasingly, evidence argues that many neurodegenerative diseases, including progressive supranuclear palsy (PSP), are caused by prions, which are…”
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Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCAA53T) mouse lines by Woerman, Amanda L., Oehler, Abby, Kazmi, Sabeen A., Lee, Jisoo, Halliday, Glenda M., Middleton, Lefkos T., Gentleman, Steve M., Mordes, Daniel A., Spina, Salvatore, Grinberg, Lea T., Olson, Steven H., Prusiner, Stanley B.

“…Previously, we reported that intracranial inoculation of brain homogenate from multiple system atrophy (MSA) patient samples produces neurological disease in…”
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Interactions between APP secretases and inflammatory mediators by Sastre, Magdalena, Walter, Jochen, Gentleman, Steve M

“…There is now a large body of evidence linking inflammation to Alzheimer's disease (AD). This association manifests itself neuropathologically in the presence…”
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Amyloid pathology and axonal injury after brain trauma by Scott, Gregory, Ramlackhansingh, Anil F, Edison, Paul, Hellyer, Peter, Cole, James, Veronese, Mattia, Leech, Rob, Greenwood, Richard J, Turkheimer, Federico E, Gentleman, Steve M, Heckemann, Rolf A, Matthews, Paul M, Brooks, David J, Sharp, David J

“…OBJECTIVE:To image β-amyloid (Aβ) plaque burden in long-term survivors of traumatic brain injury (TBI), test whether traumatic axonal injury and Aβ are…”
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The aftermath of boxing revisited: identifying chronic traumatic encephalopathy pathology in the original Corsellis boxer series by Goldfinger, Marc H., Ling, Helen, Tilley, Bension S., Liu, Alan K. L., Davey, Karen, Holton, Janice L., Revesz, Tamas, Gentleman, Steve M.

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Linking environmental risk factors with epigenetic mechanisms in Parkinson’s disease by Tsalenchuk, Maria, Gentleman, Steve M., Marzi, Sarah J.

“…Sporadic Parkinson’s disease (PD) is a progressive neurodegenerative disease, with a complex risk structure thought to be influenced by interactions between…”
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Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's by Toomey, Christina E, Heywood, Wendy E, Evans, James R, Lachica, Joanne, Pressey, Sarah N, Foti, Sandrine C, Al Shahrani, Mesfer, D'Sa, Karishma, Hargreaves, Iain P, Heales, Simon, Orford, Michael, Troakes, Claire, Attems, Johannes, Gelpi, Ellen, Palkovits, Miklos, Lashley, Tammaryn, Gentleman, Steve M, Revesz, Tamas, Mills, Kevin, Gandhi, Sonia

“…The molecular drivers of early sporadic Parkinson's disease (PD) remain unclear, and the presence of widespread end stage pathology in late disease masks the…”
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Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson's disease with cognitive decline by Liu, Alan King Lun, Chau, Tsz Wing, Lim, Ernest Junwei, Ahmed, Idil, Chang, Raymond Chuen-Chung, Kalaitzakis, Michail E, Graeber, Manuel B, Gentleman, Steve M, Pearce, Ronald K B

“…Although the precise neuropathological substrates of cognitive decline in Parkinson's disease (PD) remain elusive, it has long been regarded that pathology in…”
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Rationalisation and Validation of an Acrylamide-Free Procedure in Three-Dimensional Histological Imaging by Lai, Hei Ming, Liu, Alan King Lun, Ng, Wai-Lung, DeFelice, John, Lee, Wing Sang, Li, Heng, Li, Wen, Ng, Ho Man, Chang, Raymond Chuen-Chung, Lin, Bin, Wu, Wutian, Gentleman, Steve M

“…Three-dimensional visualization of intact tissues is now being achieved by turning tissues transparent. CLARITY is a unique tissue clearing technique, which…”
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Phenotypic profile of alternative activation marker CD163 is different in Alzheimer's and Parkinson's disease by Pey, Peixuan, Pearce, Ronald K B, Kalaitzakis, Michail E, Griffin, W Sue T, Gentleman, Steve M

“…Microglial activation is a pathological feature common to both Alzheimer's and Parkinson's diseases (AD and PD). The classical activation involves release of…”
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Locus Coeruleus Pathology Indicates a Continuum of Lewy Body Dementia by Tilley, Bension S, Patel, Shivani R, Goldfinger, Marc H, Pearce, Ronald K B, Gentleman, Steve M

“…Lewy body dementia (LBD) has two main phenotypes: Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), separated by the 'one-year-rule'…”
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Author Correction: Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues by Lai, Hei Ming, Liu, Alan King Lun, Ng, Harry Ho Man, Goldfinger, Marc H., Chau, Tsz Wing, DeFelice, John, Tilley, Bension S., Wong, Wai Man, Wu, Wutian, Gentleman, Steve M.

“…In the original version of this Article, the concentration of boric acid buffer for the SDS clearing solution was given incorrectly as ‘1 M sodium borate’ and…”
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NSAIDs: How they Work and their Prospects as Therapeutics in Alzheimer's Disease by Sastre, Magdalena, Gentleman, Steve M

“…There is significant epidemiological evidence to suggest that there are beneficial effects of treatment with non-steroidal anti-inflammatory drugs (NSAIDs) in…”
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