Search Results - "Gentleman, Stephen M"

Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease by Pienaar, Ilse S, Lee, Cecilia Heyne, Elson, Joanna L, McGuinness, Louisa, Gentleman, Stephen M, Kalaria, Raj N, Dexter, David T

“…Abstract Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has become an accepted treatment for motor symptoms in a subset of Parkinson's disease…”
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On the characterization of the heterogeneous mechanical response of human brain tissue by Forte, Antonio E., Gentleman, Stephen M., Dini, Daniele

“…The mechanical characterization of brain tissue is a complex task that scientists have tried to accomplish for over 50 years. The results in the literature…”
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Variation at the TRIM11 locus modifies progressive supranuclear palsy phenotype by Jabbari, Edwin, Woodside, John, Tan, Manuela M. X., Shoai, Maryam, Pittman, Alan, Ferrari, Raffaele, Mok, Kin Y., Zhang, David, Reynolds, Regina H., de Silva, Rohan, Grimm, Max‐Joseph, Respondek, Gesine, Müller, Ulrich, Al‐Sarraj, Safa, Gentleman, Stephen M., Lees, Andrew J., Warner, Thomas T., Hardy, John, Revesz, Tamas, Höglinger, Günter U., Holton, Janice L., Ryten, Mina, Morris, Huw R.

“…Objective The basis for clinical variation related to underlying progressive supranuclear palsy (PSP) pathology is unknown. We performed a genome‐wide…”
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Ergothioneine treatment protects neurons against N-methyl-D-aspartate excitotoxicity in an in vivo rat retinal model by MONCASTER, Juliet A, WALSH, Desmond T, GENTLEMAN, Stephen M, JEN, Ling-Sun, ARUOMA, Okezie I

“…Injection of the glutamate agonist N-methyl-D-aspartate into the vitreous body of the rat eye resulted in a number of morphological changes in the retina. Most…”
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Neuropathology of cigarette smoking by Chang, Raymond Chuen-Chung, Ho, Yuen-Shan, Wong, Shun, Gentleman, Stephen M., Ng, Ho-Keung

“…It is well established that cigarette smoking is hazardous to health and is a risk factor for many chronic diseases. However, its impact on the brain, whether…”
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Differential effects of interleukin-1β and S100B on amyloid precursor protein in rat retinal neurons by Anderson, Peter

“…Purpose: Interleukin-1β (IL-1β) and S100B calcium binding protein B (S100B) have been implicated in the pathogenesis of Alzheimer’s disease. Both are present…”
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Striatal β-Amyloid Deposition in Parkinson Disease With Dementia by Kalaitzakis, Michail E, Graeber, Manuel B, Gentleman, Stephen M, Pearce, Ronald K. B

“…Dementia is common in Parkinson disease (PD), although its anatomic and pathologic substrates remain undefined. Recently, striatal abnormalities in Lewy body…”
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Amyloid-Beta Peptide Is Toxic to Neurons In Vivo via Indirect Mechanisms by Walsh, Desmond T., Montero, Rosa M., Bresciani, Laura G., Jen, Angela Y.T., Leclercq, Pascale D., Saunders, Debbie, EL-Amir, Ahmed N., Gbadamoshi, Lukemann, Gentleman, Stephen M., Jen, Ling-Sun

“…We have studied the neurotoxicity of amyloid-beta (Aβ) after a single unilateral intravitreal injection. Within the retina apoptotic cells were seen throughout…”
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Loss of angiotensin II receptor expression in dopamine neurons in Parkinson's disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation by Zawada, W Michael, Mrak, Robert E, Biedermann, JoAnn, Palmer, Quinton D, Gentleman, Stephen M, Aboud, Orwa, Griffin, W Sue T

“…In rodent models of Parkinson's disease (PD), dopamine neuron loss is accompanied by increased expression of angiotensin II (AngII), its type 1 receptor (AT1),…”
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Axonal injury is accentuated in the caudal corpus callosum of head-injured patients by Leclercq, P D, McKenzie, J E, Graham, D I, Gentleman, S M

“…Amyloid precursor protein (APP) accumulation is a sensitive marker for the axonal damage that is commonly seen in the brain as the result of head injury. This…”
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Controversies over the staging of α-synuclein pathology in Parkinson’s disease by Kalaitzakis, Michail E., Graeber, Manuel B., Gentleman, Stephen M., Pearce, Ronald K. B.

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Increase in HLA-DR Immunoreactive Microglia in Frontal and Temporal Cortex of Chronic Schizophrenics by RADEWICZ, KATRINA, GAREY, LAURENCE J, GENTLEMAN, STEPHEN M, REYNOLDS, RICHARD

“…Glia play a major role in neuronal migration, synapse formation, and control of neurotransmission in the developing and mature nervous system. This study…”
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Tau acts as an independent genetic risk factor in pathologically proven PD by Charlesworth, Gavin, Gandhi, Sonia, Bras, Jose M, Barker, Roger A, Burn, David J, Chinnery, Patrick F, Gentleman, Stephen M, Guerreiro, Rita, Hardy, John, Holton, Janice L, Lees, Andrew, Morrison, Karen, Sheerin, Una-Marie, Williams, Nigel, Morris, Huw, Revesz, Tamas, Wood, Nicholas W

“…Abstract MAPT has been repeatedly linked with Parkinson's disease (PD) in association studies. Although tau deposition may be seen in PD, its relevance to the…”
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Acute and chronic effects of intravitreally injected β-amyloid on the neurotransmitter system in the retina by Aruoma, Okezie I, Jen, Sheila S.M, Watts, Helena R, George, Joseph, Gentleman, Stephen M, Anderson, Peter J.B, Jen, Ling-Sun

“…Abstract The potential cytotoxic effect of aggregated Aβ1–42 to neurons that express classical neurotransmitters, including acetylcholine, gamma-amino butyric…”
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Response from Authors by Kalaitzakis, Michail E, Graeber, Manuel B, Gentleman, Stephen M, Pearce, Ronald K. B

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Alterations in presenilin 1 processing by amyloid-β peptide in the rat retina by WATTS, Helena R, VINCE, Valerie, WALSH, Desmond T, BRESCIANI, Laura G, GENTLEMAN, Stephen M, JEN, Ling-Sun, ANDERSON, Peter J. B

“…Accumulating evidence indicates that mutations in the presenilin 1 (PS1) gene are responsible for most cases of familial Alzheimer's disease (AD). Although its…”
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Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy by Kovacs, Gabor G., Ferrer, Isidro, Grinberg, Lea T., Alafuzoff, Irina, Attems, Johannes, Budka, Herbert, Cairns, Nigel J., Crary, John F., Duyckaerts, Charles, Ghetti, Bernardino, Halliday, Glenda M., Ironside, James W., Love, Seth, Mackenzie, Ian R., Munoz, David G., Murray, Melissa E., Nelson, Peter T., Takahashi, Hitoshi, Trojanowski, John Q., Ansorge, Olaf, Arzberger, Thomas, Baborie, Atik, Beach, Thomas G., Bieniek, Kevin F., Bigio, Eileen H., Bodi, Istvan, Dugger, Brittany N., Feany, Mel, Gelpi, Ellen, Gentleman, Stephen M., Giaccone, Giorgio, Hatanpaa, Kimmo J., Heale, Richard, Hof, Patrick R., Hofer, Monika, Hortobágyi, Tibor, Jellinger, Kurt, Jicha, Gregory A., Ince, Paul, Kofler, Julia, Kövari, Enikö, Kril, Jillian J., Mann, David M., Matej, Radoslav, McKee, Ann C., McLean, Catriona, Milenkovic, Ivan, Montine, Thomas J., Murayama, Shigeo, Lee, Edward B., Rahimi, Jasmin, Rodriguez, Roberta D., Rozemüller, Annemieke, Schneider, Julie A., Schultz, Christian, Seeley, William, Seilhean, Danielle, Smith, Colin, Tagliavini, Fabrizio, Takao, Masaki, Thal, Dietmar Rudolf, Toledo, Jon B., Tolnay, Markus, Troncoso, Juan C., Vinters, Harry V., Weis, Serge, Wharton, Stephen B., White, Charles L., Wisniewski, Thomas, Woulfe, John M., Yamada, Masahito, Dickson, Dennis W.

“…Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its…”
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A need to clarify the role of apolipoprotein E in peripheral nerve injury and repair by Geranmayeh, Fatemeh, Christian, Lynne, Turkheimer, Federico E, Gentleman, Stephen M, O'Neill, Kevin S

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Up-regulation of soluble amyloid precursor protein fragment secretion in the rat retina in vivo by metabotropic glutamate receptor stimulation by Croucher, Martin J, Patel, Hemanshu, Walsh, Desmond T, Moncaster, Juliet A, Gentleman, Stephen M, Fazal, Abidali, Jen, Ling-Sun

“…Using the novel rat retinal-vitreal model we have investigated the effect of metabotropic glutamate receptor activation on amyloid precursor protein (APP)…”
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The antioxidant cocktail, effective microorganism X (EM-X), protects retinal neurons in rats against N-methyl-D-aspartate excitotoxicity in vivo by Aruoma, Okezie I, Moncaster, Juliet A, Walsh, Desmond T, Gentleman, Stephen M, Ke, Bin, Liang, Yun-Fei, Higa, Teruo, Jen, Ling Sun

“…Injection of the glutamate agonist N-methyl-D-aspartate (NMDA) into the vitreous body of rats resulted in severe degeneration of neurons in the retina, with a…”
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