Search Results - "Gentle, Ian E"

A non‐death function of the mitochondrial apoptosis apparatus in immunity by Brokatzky, Dominik, Dörflinger, Benedikt, Haimovici, Aladin, Weber, Arnim, Kirschnek, Susanne, Vier, Juliane, Metz, Arlena, Henschel, Julia, Steinfeldt, Tobias, Gentle, Ian E, Häcker, Georg

“…Apoptosis is a frequent form of programmed cell death, but the apoptotic signaling pathway can also be engaged at a low level, in the absence of cell death. We…”
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Diversity of cell death signaling pathways in macrophages upon infection with modified vaccinia virus Ankara (MVA) by Klaas, Lioba, Vier, Juliane, Gentle, Ian E., Häcker, Georg, Kirschnek, Susanne

“…Regulated cell death frequently occurs upon infection by intracellular pathogens, and extent and regulation is often cell-type-specific. We aimed to identify…”
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Molecular architecture and function of the Omp85 family of proteins by Gentle, Ian E., Burri, Lena, Lithgow, Trevor

“…Summary Omp85 is a protein found in Gram‐negative bacteria where it serves to integrate proteins into the bacterial outer membrane. Members of the Omp85 family…”
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Supramolecular Complexes in Cell Death and Inflammation and Their Regulation by Autophagy by Gentle, Ian E

“…Signaling activation is a tightly regulated process involving myriad posttranslational modifications such as phosphorylation/dephosphorylation,…”
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Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post-transcriptional regulator Ccr4-Pop2 by Dagley, Michael J, Gentle, Ian E, Beilharz, Traude H, Pettolino, Filomena A, Djordjevic, Julianne T, Lo, Tricia L, Uwamahoro, Nathalie, Rupasinghe, Thusitha, Tull, Dedreja L, McConville, Malcolm, Beaurepaire, Cecile, Nantel, André, Lithgow, Trevor, Mitchell, Aaron P, Traven, Ana

“…The cell wall is essential for viability of fungi and is an effective drug target in pathogens such as Candida albicans. The contribution of…”
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Mitochondrial Metabolomics of Sym1-Depleted Yeast Cells Revealed Them to Be Lysine Auxotroph by Lagies, Simon, Pan, Daqiang, Mohl, Daniel A, Plattner, Dietmar A, Gentle, Ian E, Kammerer, Bernd

“…Metabolomics has expanded from cellular to subcellular level to elucidate subcellular compartmentalization. By applying isolated mitochondria to metabolome…”
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Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins by Goodall, Katharine J, Finch-Edmondson, Megan L, van Vuuren, Joanne, Yeoh, George C, Gentle, Ian E, Vince, James E, Ekert, Paul G, Vaux, David L, Callus, Bernard A

“…Apoptosis mediated by Bax or Bak is usually thought to be triggered by BH3-only members of the Bcl-2 protein family. BH3-only proteins can directly bind to and…”
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Pattern Recognition Receptors of Nucleic Acids Can Cause Sublethal Activation of the Mitochondrial Apoptosis Pathway during Viral Infection by Gradzka-Boberda, Sylwia, Gentle, Ian E, Häcker, Georg

“…The mitochondrial apoptosis pathway has the function to kill the cell, but recent work shows that this pathway can also be activated to a sublethal level,…”
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GM‐CSF suppresses antioxidant signaling and drives IL‐1β secretion through NRF2 downregulation by Di Carlo, Sara, Häcker, Georg, Gentle, Ian E

“…GM‐CSF is a potent inflammatory cytokine regulating myeloid cell differentiation, hematopoiesis, and various other functions. It is functionally associated…”
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Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane by Burri, Lena, Strahm, Yvan, Hawkins, Christine J, Gentle, Ian E, Puryer, Michelle A, Verhagen, Anne, Callus, Bernard, Vaux, David, Lithgow, Trevor

“…DIABLO/Smac is a mitochondrial protein that can promote apoptosis by promoting the release and activation of caspases. To do so, DIABLO/Smac must first be…”
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Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak by Waguia Kontchou, Collins, Gentle, Ian E., Weber, Arnim, Schoeniger, Axel, Edlich, Frank, Häcker, Georg

“…Apoptosis acts in defense against microbial infection, and many infectious agents have developed strategies to inhibit host cell apoptosis. The human pathogen…”
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Conserved substrate binding by chaperones in the bacterial periplasm and the mitochondrial intermembrane space by Alcock, Felicity H, Grossmann, J Günter, Gentle, Ian E, Likić, Vladimir A, Lithgow, Trevor, Tokatlidis, Kostas

“…Mitochondria were derived from intracellular bacteria and the mitochondrial intermembrane space is topologically equivalent to the bacterial periplasm. Both…”
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Infection of epithelial cells with Chlamydia trachomatis inhibits TNF‐induced apoptosis at the level of receptor internalization while leaving non‐apoptotic TNF‐signalling intact by Waguia Kontchou, Collins, Tzivelekidis, Tina, Gentle, Ian E, Häcker, Georg

“…Summary Chlamydia trachomatis is an obligate intracellular bacterial pathogen of medical importance. C. trachomatis develops inside a membranous vacuole in the…”
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TIR‐domain‐containing adapter‐inducing interferon‐β (TRIF) forms filamentous structures, whose pro‐apoptotic signalling is terminated by autophagy by Gentle, Ian E., McHenry, Kevin T., Weber, Arnim, Metz, Arlena, Kretz, Oliver, Porter, Dale, Häcker, Georg

“…The formation of amyloid‐like protein structures has recently emerged as a feature in signal transduction, particularly in innate immunity. These structures…”
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The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection by Moeed, Abdul, Thilmany, Nico, Beck, Frederic, Puthussery, Bhagya K., Ortmann, Noemi, Haimovici, Aladin, Badr, M. Tarek, Haghighi, Elham Bavafaye, Boerries, Melanie, Öllinger, Rupert, Rad, Roland, Kirschnek, Susanne, Gentle, Ian E., Donakonda, Sainitin, Petric, Philipp P., Hummel, Jonas F., Pfaffendorf, Elisabeth, Zanetta, Paola, Schell, Christoph, Schwemmle, Martin, Weber, Arnim, Häcker, Georg

“…Mitochondria react to infection with sub-lethal signals in the apoptosis pathway. Mitochondrial signals can be inflammatory but mechanisms are only partially…”
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Inhibitors of apoptosis proteins (IAPs) are required for effective T-cell expansion/survival during antiviral immunity in mice by Gentle, Ian E., Moelter, Isabel, Lechler, Nadja, Bambach, Sarah, Vucikuja, Smiljka, Häcker, Georg, Aichele, Peter

“…Inhibitors of apoptosis proteins (IAPs) were originally described as regulating apoptosis by direct binding to caspases. More recently, IAPs have been…”
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Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes by Gradzka, Sylwia, Thomas, Oliver S., Kretz, Oliver, Haimovici, Aladin, Vasilikos, Lazaros, Wong, Wendy Wei-Lynn, Häcker, Georg, Gentle, Ian E.

“…Inhibitor of Apoptosis Proteins act as E3 ubiquitin ligases to regulate NF-κB signalling from multiple pattern recognition receptors including NOD2, as well as…”
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New perspectives in TNF-R1-induced NF-κB signaling by Gentle, Ian E, Silke, John

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In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8 by Gentle, Ian E., Wong, W. Wei-Lynn, Evans, Joseph M., Bankovacki, Alexandra, Cook, Wendy D., Khan, Nufail R., Nachbur, Ulrich, Rickard, James, Anderton, Holly, Moulin, Maryline, Lluis, Josep Maria, Moujalled, Donia M., Silke, John, Vaux, David L.

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Conserved Motifs Reveal Details of Ancestry and Structure in the Small TIM Chaperones of the Mitochondrial Intermembrane Space by Gentle, Ian E., Perry, Andrew J., Alcock, Felicity H., Liki, Vladimir A., Dolezal, Pavel, Ng, Ee Ting, Purcell, Anthony W., McConnville, Malcolm, Naderer, Thomas, Chanez, Anne-Laure, Charrière, Fabien, Aschinger, Caroline, Schneider, André, Tokatlidis, Kostas, Lithgow, Trevor

“…The mitochondrial inner and outer membranes are composed of a variety of integral membrane proteins, assembled into the membranes posttranslationally. The…”
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