Roles of mesenchymal stromal cells in the head and neck cancer microenvironment

Head and neck cancer (HNC), a common malignancy worldwide, is associated with high morbidity and mortality rates. Squamous cell carcinoma is the most common HNC type, followed by salivary gland carcinomas, head and neck sarcomas, and lymphomas. The microenvironment of HNCs comprises various cells th...

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Bibliographic Details
Published in:	Biomedicine & pharmacotherapy Vol. 144; p. 112269
Main Authors:	de Miranda, Marcelo Coutinho, Melo, Mariane Izabella Abreu de, Cunha, Pricila da Silva, Gentilini, Jovino, Faria, Jerusa Araújo Quintão Arantes, Rodrigues, Michele Angela, Gomes, Dawidson Assis
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01-12-2021 Elsevier
Subjects:	Biomarkers, Tumor Cancer metastasis Cancer microenvironment Carcinoma, Squamous Cell - pathology Epithelial-Mesenchymal Transition Head and neck cancer Head and Neck Neoplasms - pathology Humans Mesenchymal Stem Cells - pathology Mesenchymal stromal cells Neoplasm Metastasis Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - pathology Tumor Microenvironment Mesenchymal stromal cells Head and neck cancer Squamous cell carcinoma Cancer metastasis Cancer microenvironment
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Summary:	Head and neck cancer (HNC), a common malignancy worldwide, is associated with high morbidity and mortality rates. Squamous cell carcinoma is the most common HNC type, followed by salivary gland carcinomas, head and neck sarcomas, and lymphomas. The microenvironment of HNCs comprises various cells that regulate tumor development. Recent studies have reported that the tumor microenvironment, which modulates cancer progression, regulates cancer treatment response. However, the presence of different types of stromal cells in cancers is a major challenge to elucidate the role of individual cells in tumor progression. The role of mesenchymal stromal cells (MSCs), which are a component of the tumor microenvironment, in HNC is unclear. The major impediment for characterizing the role of MSCs in cancer progression is the lack of MSC-specific markers and their phenotypic similarity with stromal cells. This review aimed to summarize the latest findings on the role of MSCs in the progression of HNC to improve our understanding of HNC pathophysiology. [Display omitted] •We review evidences for the MSC secretome on the HNC microenviroment and progression.•We describe bidirecional communication between MSC and HNC on cell phenotypes.•We summarize in vitro and in vivo studies perfomed in HNC model.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Credit Author Statement Marcelo Coutinho de Miranda did the conceptualization and wrote the original draft; Mariane Izabella Abreu de Melo, Pricila da Silva Cunha, Jovino Gentilini Júnior, and Michele Angela Rodrigues participated in data interpretation and discussion; Jerusa Araújo Quintão Arantes Faria and Dawidson Assis Gomes reviewed and edited the manuscript. Author contributions MCM did the conceptualization and wrote the original draft; MIAM, PSC, JGJ, and MAR participated in data interpretation and discussion.; JAQAF and DAG reviewed and edited the manuscript.
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2021.112269