Search Results - "Genové, Guillem"

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis by GAENGEL, Konstantin, GENOVE, Guillem, ARMULIK, Annika, BETSHOLTZ, Christer

“…Mural cells are essential components of blood vessels and are necessary for normal development, homeostasis, and organ function. Alterations in mural cell…”
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Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination by Muhl, Lars, Genové, Guillem, Leptidis, Stefanos, Liu, Jianping, He, Liqun, Mocci, Giuseppe, Sun, Ying, Gustafsson, Sonja, Buyandelger, Byambajav, Chivukula, Indira V., Segerstolpe, Åsa, Raschperger, Elisabeth, Hansson, Emil M., Björkegren, Johan L. M., Peng, Xiao-Rong, Vanlandewijck, Michael, Lendahl, Urban, Betsholtz, Christer

“…Many important cell types in adult vertebrates have a mesenchymal origin, including fibroblasts and vascular mural cells. Although their biological importance…”
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Early Loss of Pericytes and Perivascular Stromal Cell-Induced Scar Formation after Stroke by Fernández-Klett, Francisco, Potas, Jason R, Hilpert, Diana, Blazej, Katja, Radke, Josefine, Huck, Jojanneke, Engel, Odilo, Stenzel, Werner, Genové, Guillem, Priller, Josef

“…Despite its limited regenerative capacity, the central nervous system (CNS) shares more repair mechanisms with peripheral tissues than previously recognized…”
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Loss of Regulator of G-Protein Signaling 5 Leads to Neurovascular Protection in Stroke by Özen, Ilknur, Roth, Michaela, Barbariga, Marco, Gaceb, Abderahim, Deierborg, Tomas, Genové, Guillem, Paul, Gesine

“…BACKGROUND AND PURPOSE—In ischemic stroke, breakdown of the blood-brain barrier (BBB) aggravates brain damage. Pericyte detachment contributes to BBB…”
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Pericytes regulate the blood-brain barrier by Armulik, Annika, Betsholtz, Christer, Genové, Guillem, Mäe, Maarja, Nisancioglu, Maya H, Wallgard, Elisabet, Niaudet, Colin, He, Liqun, Norlin, Jenny, Lindblom, Per, Strittmatter, Karin, Johansson, Bengt R

“…The blood-brain barrier (BBB) consists of specific physical barriers, enzymes and transporters, which together maintain the necessary extracellular environment…”
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Brain pericytes acquire a microglial phenotype after stroke by Özen, Ilknur, Deierborg, Tomas, Miharada, Kenichi, Padel, Thomas, Englund, Elisabet, Genové, Guillem, Paul, Gesine

“…Pericytes are located on the abluminal side of endothelial cells lining the microvasculature in all organs. They have been identified as multipotent progenitor…”
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Regulator of G‐protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke by Roth, Michaela, Gaceb, Abderahim, Enström, Andreas, Padel, Thomas, Genové, Guillem, Özen, Ilknur, Paul, Gesine

“…ABSTRACT Poststroke recovery requires multiple repair mechanisms, including vascular remodeling and blood‐brain barrier (BBB) restoration. Brain pericytes are…”
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Endogenous brain pericytes are widely activated and contribute to mouse glioma microvasculature by Svensson, Andreas, Özen, Ilknur, Genové, Guillem, Paul, Gesine, Bengzon, Johan

“…Glioblastoma multiforme (GBM) is the most common brain tumor in adults. It presents an extremely challenging clinical problem, and treatment very frequently…”
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Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts by Uhrbom, Martin, Muhl, Lars, Genové, Guillem, Liu, Jianping, Palmgren, Henrik, Alexandersson, Ida, Karlsson, Fredrik, Zhou, Alex-Xianghua, Lunnerdal, Sandra, Gustafsson, Sonja, Buyandelger, Byambajav, Petkevicius, Kasparas, Ahlstedt, Ingela, Karlsson, Daniel, Aasehaug, Leif, He, Liqun, Jeansson, Marie, Betsholtz, Christer, Peng, Xiao-Rong

“…Cell identities are defined by intrinsic transcriptional networks and spatio-temporal environmental factors. Here, we explored multiple factors that contribute…”
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Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain by Saeed, Ahmed A., Genové, Guillem, Li, Tian, Lütjohann, Dieter, Olin, Maria, Mast, Natalia, Pikuleva, Irina A., Crick, Peter, Wang, Yuqin, Griffiths, William, Betsholtz, Christer, Björkhem, Ingemar

“…The presence of the blood-brain barrier (BBB) is critical for cholesterol metabolism in the brain, preventing uptake of lipoprotein-bound cholesterol from the…”
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A single-cell transcriptomic inventory of murine smooth muscle cells by Muhl, Lars, Mocci, Giuseppe, Pietilä, Riikka, Liu, Jianping, He, Liqun, Genové, Guillem, Leptidis, Stefanos, Gustafsson, Sonja, Buyandelger, Byambajav, Raschperger, Elisabeth, Hansson, Emil M, Björkegren, Johan L M, Vanlandewijck, Michael, Lendahl, Urban, Betsholtz, Christer

“…Smooth muscle cells (SMCs) execute important physiological functions in numerous vital organ systems, including the vascular, gastrointestinal, respiratory,…”
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Parenchymal pericytes are not the major contributor of extracellular matrix in the fibrotic scar after stroke in male mice by Roth, Michaela, Enström, Andreas, Aghabeick, Candice, Carlsson, Robert, Genové, Guillem, Paul, Gesine

“…Scar formation after injury of the brain or spinal cord is a common event. While glial scar formation by astrocytes has been extensively studied, much less is…”
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Retinoic acid receptor responder1 promotes development of glomerular diseases via the Nuclear Factor-κB signaling pathway by Möller-Hackbarth, Katja, Dabaghie, Dina, Charrin, Emmanuelle, Zambrano, Sonia, Genové, Guillem, Li, Xidan, Wernerson, Annika, Lal, Mark, Patrakka, Jaakko

“…Inflammatory pathways are activated in most glomerular diseases but molecular mechanisms driving them in kidney tissue are poorly known. We identified retinoic…”
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Hypertension‐evoked RhoA activity in vascular smooth muscle cells requires RGS5 by Arnold, Caroline, Demirel, Eda, Feldner, Anja, Genové, Guillem, Zhang, Hangjun, Sticht, Carsten, Wieland, Thomas, Hecker, Markus, Heximer, Scott, Korff, Thomas

“…G protein–mediated signaling plays a decisive role in blood pressure regulation and the phenotype of vascular smooth muscle cells (VSMCs); however, the…”
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RGS5 Determines Neutrophil Migration in the Acute Inflammatory Phase of Bleomycin-Induced Lung Injury by Sharma, Neha, Nagaraj, Chandran, Nagy, Bence M., Marsh, Leigh M., Bordag, Natalie, Zabini, Diana, Wygrecka, Malgorzata, Klepetko, Walter, Gschwandtner, Elisabeth, Genové, Guillem, Heinemann, Akos, Weir, E Kenneth, Kwapiszewska, Grazyna, Olschewski, Horst, Olschewski, Andrea

“…The regulator of G protein signaling (RGS) represents a widespread system of controllers of cellular responses. The activities of the R4 subfamily of RGSs have…”
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The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research by Muhl, Lars, He, Liqun, Sun, Ying, Andaloussi Mäe, Maarja, Pietilä, Riikka, Liu, Jianping, Genové, Guillem, Zhang, Lei, Xie, Yuan, Leptidis, Stefanos, Mocci, Giuseppe, Stritt, Simon, Osman, Ahmed, Anisimov, Andrey, Hemanthakumar, Karthik Amudhala, Räsänen, Markus, Hansson, Emil M., Björkegren, Johan, Vanlandewijck, Michael, Blomgren, Klas, Mäkinen, Taija, Peng, Xiao-Rong, Hu, Yizhou, Ernfors, Patrik, Arnold, Thomas D., Alitalo, Kari, Lendahl, Urban, Betsholtz, Christer

“…Humanized mouse models and mouse-adapted SARS-CoV-2 virus are increasingly used to study COVID-19 pathogenesis, so it is important to learn where the…”
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Publisher Correction: Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination by Muhl, Lars, Genové, Guillem, Leptidis, Stefanos, Liu, Jianping, He, Liqun, Mocci, Giuseppe, Sun, Ying, Gustafsson, Sonja, Buyandelger, Byambajav, Chivukula, Indira V., Segerstolpe, Åsa, Raschperger, Elisabeth, Hansson, Emil M., Björkegren, Johan L. M., Peng, Xiao-Rong, Vanlandewijck, Michael, Lendahl, Urban, Betsholtz, Christer

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells by Hong, JongWook, Tobin, Nicholas P, Rundqvist, Helene, Li, Tian, Lavergne, Marion, García-Ibáñez, Yaiza, Qin, Hanyu, Paulsson, Janna, Zeitelhofer, Manuel, Adzemovic, Milena Z, Nilsson, Ingrid, Roswall, Pernilla, Hartman, Johan, Johnson, Randall S, Östman, Arne, Bergh, Jonas, Poljakovic, Mirjana, Genové, Guillem

“…Pericytes are members of the tumor stroma; however, little is known about their origin, function, or interaction with other tumor components. Emerging evidence…”
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Generation and Characterization of rgs5 Mutant Mice by Nisancioglu, Maya H., Mahoney, William M., Kimmel, Dara D., Schwartz, Stephen M., Betsholtz, Christer, Genové, Guillem

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier by Mäe, Maarja Andaloussi, Li, Tian, Bertuzzi, Giacomo, Raschperger, Elisabeth, Vanlandewijck, Michael, He, Liqun, Nahar, Khayrun, Dalheim, Annika, Hofmann, Jennifer J., Laviña, Bàrbara, Keller, Annika, Betsholtz, Christer, Genové, Guillem

“…Diabetes mellitus is associated with cognitive impairment and various central nervous system pathologies such as stroke, vascular dementia, or Alzheimer’s…”
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