Search Results - "Genkin, Dmitry"

AAV‐mediated gene transfer of DNase I in the liver of mice with colorectal cancer reduces liver metastasis and restores local innate and adaptive immune response by Xia, Yujia, He, Jiayi, Zhang, Hongji, Wang, Han, Tetz, George, Maguire, Casey A., Wang, Yu, Onuma, Amblessed, Genkin, Dmitry, Tetz, Victor, Stepanov, Alexey, Terekhov, Stanislav, Ukrainskaya, Valeria, Huang, Hai, Tsung, Allan

“…Liver metastasis is a major cause of colorectal cancer‐related death. Although DNase I displays antimetastatic activity by inhibition of NETs, its clinical use…”
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Chemical polysialylation of human recombinant butyrylcholinesterase delivers a long-acting bioscavenger for nerve agents in vivo by Ilyushin, Denis G., Smirnov, Ivan V., Belogurov, Alexey A., Dyachenko, Igor A., Zharmukhamedova, Tatiana lu, Novozhilova, Tatjana I., Bychikhin, Eugene A., Serebryakova, Marina V., Kharybin, Oleg N., Murashev, Arkadii N., Anikienko, Konstantin A., Nikolaev, Eugene N., Ponomarenko, Natalia A., Genkin, Dmitry D., Blackburn, G. Michael, Masson, Patrick, Gabibov, Alexander G.

“…The creation of effective bioscavengers as a pretreatment for exposure to nerve agents is a challenging medical objective. We report a recombinant method using…”
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Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients by Gabibov, A. G., Genkin, Dmitry, Okunola, John, Zakharov, Konstantin, Stepanov, Alexey, Glagoleva, Irina, Belogurov, Alexey, Lomakin, Yakov, Smirnov, Ivan

“…We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic…”
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Liposome‐encapsulated peptides protect against experimental allergic encephalitis by Belogurov, Alexey A., Stepanov, Alexey V., Smirnov, Ivan V., Melamed, Dobroslav, Bacon, Andrew, Mamedov, Azad E., Boitsov, Vitali M., Sashchenko, Lidia P., Ponomarenko, Natalia A., Sharanova, Svetlana N., Boyko, Alexey N., Dubina, Michael V., Friboulet, Alain, Genkin, Dmitry D., Gabibov, Alexander G.

“…Multiple sclerosis (MS) is a severe inflammatory and neurodegenerative disease with an autoimmune background. Despite the variety of therapeutics available…”
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Strategies for induction of catalytic antibodies toward HIV-1 glycoprotein gp120 in autoimmune prone mice by Durova, Oxana M., Vorobiev, Ivan I., Smirnov, Ivan V., Reshetnyak, Andrew V., Telegin, Georgy B., Shamborant, Olga G., Orlova, Nadezda A., Genkin, Dmitry D., Bacon, Andrew, Ponomarenko, Natalia A., Friboulet, Alain, Gabibov, Alexander G.

“…Tremendous efforts to produce an efficient vaccine for HIV infection have been unsuccessful. The ability of HIV to utilize sophisticated mechanisms to escape…”
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Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma by Stepanov, Alexey V, Markov, Oleg V, Chernikov, Ivan V, Gladkikh, Daniil V, Zhang, Hongkai, Jones, Teresa, Sen'kova, Alexandra V, Chernolovskaya, Elena L, Zenkova, Marina A, Kalinin, Roman S, Rubtsova, Maria P, Meleshko, Alexander N, Genkin, Dmitry D, Belogurov, Jr, Alexey A, Xie, Jia, Gabibov, Alexander G, Lerner, Richard A

“…We report the development of a novel platform to enhance the efficacy and safety of follicular lymphoma (FL) treatment. Since lymphoma is a clonal malignancy…”
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Chemical Polysialylation of Recombinant Human Proteins by Smirnov, Ivan V, Vorobiev, Ivan I, Belogurov, Alexey A, Genkin, Dmitry D, Deyev, Sergey M, Gabibov, Alexander G

“…Design of drug with prolonged therapeutic action is one of the rapid developing fields of modern medical science and required implementation of different…”
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Neutrophil extracellular traps blockade in combination with PD-1 inhibition in treatment of colorectal cancer metastasis by Onuma, Amblessed, He, Jiayi, Xia, Yujia, Zhang, Hongji, Genkin, Dmitry, Tetz, George, Huang, Hai, Tsung, Allan

“…Abstract only e16002 Background: Immune checkpoint inhibitors (ICIs) are currently approved for microsatellite instability-high metastatic colorectal cancer…”
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Abstract B048: Neutrophil extracellular traps-targeting DNase I enhances the therapeutic efficacy of CAR-T cell adoptive immunotherapy in a syngeneic murine metastasis model by Stepanov, Alexey, Wang, Wenjian, Hou, Yingqin, Ivan Chernikov, Ivan Chernikov, Bissonnette, Reid, Tetz, George, Borisenko, Grigory, Genkin, Dmitry

“…In recent years, chimeric antigen receptor (CAR) T cell therapy has emerged as a promising approach for treating various malignancies, most notably in…”
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CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human, Proof-of-Concept Dose-Escalation Study by Belogurov, Alexey, Zakharov, Konstantin, Lomakin, Yakov, Surkov, Kirill, Avtushenko, Sergey, Kruglyakov, Peter, Smirnov, Ivan, Makshakov, Gleb, Lockshin, Curtis, Gregoriadis, Gregory, Genkin, Dmitry, Gabibov, Alexander, Evdoshenko, Evgeniy

“…Previously, we showed that CD206-targeted liposomal delivery of co-encapsulated immunodominant myelin basic protein (MBP) sequences MBP 46–62 , MBP 124–139 and…”
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Chemical polysialylation: Design of conjugated human oxyntomodulin with a prolonged anorexic effect in vivo by Vorobiev, Ivan, Matskevich, Viktor, Kovnir, Sergey, Orlova, Nadezhda, Knorre, Vera, Jain, Sanjay, Genkin, Dmitry, Gabibov, Alexandre, Miroshnikov, Anatoly

“…Recombinant gut hormone oxyntomodulin (OXM) is known to act as a satiety signal in human subjects and has therapeutic potential as an appetite controlling…”
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Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-[alpha] and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients by Lomakin, Yakov, Belogurov, Alexey, Jr, Glagoleva, Irina, Stepanov, Alexey, Zakharov, Konstantin, Okunola, John, Smirnov, Ivan, Genkin, Dmitry, Gabibov, Alexander

“…We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic…”
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