Search Results - "Geng, Xiaokun"

NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease by Rastogi, Radhika, Geng, Xiaokun, Li, Fengwu, Ding, Yuchuan

“…Nicotinamide adenine dinucleotide phosphate (NAPDH) oxidase (NOX) is an enzyme complex with the sole function of producing superoxide anion and reactive oxygen…”
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Preconditioning in neuroprotection: From hypoxia to ischemia by Li, Sijie, Hafeez, Adam, Noorulla, Fatima, Geng, Xiaokun, Shao, Guo, Ren, Changhong, Lu, Guowei, Zhao, Heng, Ding, Yuchuan, Ji, Xunming

“…Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even organisms from subsequent lethal injury caused by hypoxia or…”
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Phenothiazine Inhibits Neuroinflammation and Inflammasome Activation Independent of Hypothermia After Ischemic Stroke by Guo, Sichao, Geng, Xiaokun, Lee, Hangil, Ding, Yuchuan

“…A depressive or hibernation-like effect of chlorpromazine and promethazine (C + P) on brain activity was reported to induce neuroprotection, with or without…”
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Therapeutic Target and Cell-signal Communication of Chlorpromazine and Promethazine in Attenuating Blood–Brain Barrier Disruption after Ischemic Stroke by Li, Fengwu, Geng, Xiaokun, Yip, James, Ding, Yuchuan

“…Ischemic stroke destroys blood–brain barrier (BBB) integrity. There are currently no effective treatments available in the clinical setting. Post-ischemia…”
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Exploring the Therapeutic Potential of Peritoneal Dialysis (PD) in the Treatment of Neurological Disorders by Cheng, Muyuan, Ding, Yuchuan, Kim, Enoch, Geng, Xiaokun

“…Peritoneal dialysis (PD) is a well-established renal replacement therapy commonly employed in clinical practice. While its primary application is in the…”
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Remote Ischemic Postconditioning vs. Physical Exercise After Stroke: an Alternative Rehabilitation Strategy? by Geng, Xiaokun, Wang, Qingzhu, Lee, Hangil, Huber, Christian, Wills, Melissa, Elkin, Kenneth, Li, Fengwu, Ji, Xunming, Ding, Yuchuan

“…There remain debates on neuroprotection and rehabilitation techniques for acute ischemic stroke patients. Therapeutic physical exercise following stroke has…”
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Adjuvant High-Flow Normobaric Oxygen After Mechanical Thrombectomy for Anterior Circulation Stroke: a Randomized Clinical Trial by Cheng, Zhe, Geng, Xiaokun, Tong, Yanna, Dornbos, David, Hussain, Mohammed, Rajah, Gary B., Gao, Jie, Ma, Linlin, Li, Fenghai, Du, Huishan, Fisher, Marc, Ding, Yuchuan

“…Adjuvant neuroprotective therapies for acute ischemic stroke (AIS) have demonstrated benefit in animal studies, albeit without human translation. We…”
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Dyskinesia-hyperpyrexia syndrome in Parkinson's disease triggered by overdose of levodopa - a case report and literature review by Du, Xiangnan, Wang, Xuemei, Geng, Xiaokun

“…Dyskinesia-hyperpyrexia syndrome, a rare medical emergency in Parkinson's disease, is first described in 2010. It is characterized by severe continuous…”
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In Search of a Dose: The Functional and Molecular Effects of Exercise on Post-stroke Rehabilitation in Rats by Li, Fengwu, Geng, Xiaokun, Huber, Christian, Stone, Christopher, Ding, Yuchuan

“…Although physical exercise has been demonstrated to augment recovery of the post-stroke brain, the question of what level of exercise intensity optimizes…”
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Filtered air intervention reduces inflammation and hypothalamus–pituitary–adrenal axis activation in adult male and female rats after PM 2.5 exposure by Liu, Cuiying, Yang, Jian, Guan, Longfei, Zhu, Yuequan, Geng, Xiaokun

“…Previous studies have indicated that particulate matter 2.5 (PM2.5) exposure stimulates systemic inflammation and activates the hypothalamus–pituitary–adrenal…”
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Hibernation-like neuroprotection in stroke by attenuating brain metabolic dysfunction by Forreider, Brian, Pozivilko, David, Kawaji, Qingwen, Geng, Xiaokun, Ding, Yuchuan

“…Many mammalian species naturally undergo hibernation, a process that is associated with drastic changes in metabolism and systemic physiology. Their ability to…”
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Perspectives on benefit of early and prereperfusion hypothermia by pharmacological approach in stroke by Li, Fengwu, Gao, Jie, Kohls, Wesley, Geng, Xiaokun, Ding, Yuchuan

“…Stroke kills or disables approximately 15 million people worldwide each year. It is the leading cause of brain injury, resulting in persistent neurological…”
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Neuroprotective Effects of Exercise Postconditioning After Stroke via SIRT1-Mediated Suppression of Endoplasmic Reticulum (ER) Stress by Li, Fengwu, Geng, Xiaokun, Lee, Hangil, Wills, Melissa, Ding, Yuchuan

“…While it is well-known that pre-stroke exercise conditioning reduces the incidence of stroke and the development of comorbidities, it is unclear whether…”
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Plasmacytoid Dendritic Cells Protect Against Middle Cerebral Artery Occlusion Induced Brain Injury by Priming Regulatory T Cells by Chen, Chen, Chencheng, Zhang, Cuiying, Liu, Xiaokun, Geng

“…Regulatory T cells (Tregs) play an anti-inflammatory effect to protect against ischemic stroke. Plasmacytoid dendritic cells (pDCs) can induce regulatory T…”
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Phosphoenolpyruvate Carboxykinase (PCK) in the Brain Gluconeogenic Pathway Contributes to Oxidative and Lactic Injury After Stroke by Geng, Xiaokun, Shen, Jiamei, Li, Fengwu, Yip, James, Guan, Longfei, Rajah, Gary, Peng, Changya, DeGracia, Donald, Ding, Yuchuan

“…To demonstrate the role of the rate-limiting and ATP-dependent gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PCK) in oxidative and lactic stress and…”
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Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization by Liu, Zongjian, Ran, Yuanyuan, Huang, Shuo, Wen, Shaohong, Zhang, Wenxiu, Liu, Xiangrong, Ji, Zhili, Geng, Xiaokun, Ji, Xunming, Du, Huishan, Leak, Rehana K, Hu, Xiaoming

“…Stroke is the most common type of cerebrovascular disease and is a leading cause of disability and death. Ischemic stroke accounts for approximately 80% of all…”
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Induced Inflammatory and Oxidative Markers in Cerebral Microvasculature by Mentally Depressive Stress by Zhu, Yuequan, Haddad, Yazeed, Yun, Ho Jun, Geng, Xiaokun, Ding, Yuchuan

“…Background. Cerebrovascular disease (CVD) is recognized as the leading cause of permanent disability worldwide. Depressive disorders are associated with…”
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Early neurological deterioration in acute ischemic stroke patients after intravenous thrombolysis with alteplase predicts poor 3-month functional prognosis - data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) by Che, Fengli, Wang, Anxin, Ju, Yi, Ding, Yarong, Duan, Honglian, Geng, Xiaokun, Zhao, Xingquan, Wang, Yongjun

“…We aimed to investigate the risk factors of early neurological deterioration (END) after intravenous thrombolysis with recombinant tissue-type plasminogen…”
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Rapid Intravenous Glyceryl Trinitrate in Ischemic Damage (RIGID): A potential neuroprotection strategy for acute ischemic stroke (AIS) patients by Cai, Lipeng, Ding, Yuchuan, Rajah, Gary, Tong, Yanna, Duan, Honglian, Han, Zhenzhen, Gao, Jie, Cheng, Zhe, Xin, Ruiqiang, Jiang, Shangqian, Geng, Xiaokun

“…Despite advances in intravenous thrombolysis and endovascular thrombectomy, numerous acute ischemic stroke survivors continue to experience various disability…”
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Perspectives on effect of spleen in ischemic stroke by Ding, Yarong, DeGracia, Donald, Geng, Xiaokun, Ding, Yuchuan

“…Despite decades of research, stroke therapies are limited to recanalization therapies that can only be used on <10% of stroke patients; the vast majority of…”
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