Search Results - "Genet, Gael"

Vascular endothelial cell specification in health and disease by Marziano, Corina, Genet, Gael, Hirschi, Karen K.

“…There are two vascular networks in mammals that coordinately function as the main supply and drainage systems of the body. The blood vasculature carries…”
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Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis by Genet, Gael, Boyé, Kevin, Mathivet, Thomas, Ola, Roxana, Zhang, Feng, Dubrac, Alexandre, Li, Jinyu, Genet, Nafiisha, Henrique Geraldo, Luiz, Benedetti, Lorena, Künzel, Steffen, Pibouin-Fragner, Laurence, Thomas, Jean-Leon, Eichmann, Anne

“…Endothelial cell migration, proliferation and survival are triggered by VEGF-A activation of VEGFR2. However, how these cell behaviors are regulated…”
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Lacteal junction zippering protects against diet-induced obesity by Zhang, Feng, Zarkada, Georgia, Han, Jinah, Li, Jinyu, Dubrac, Alexandre, Ola, Roxana, Genet, Gael, Boyé, Kevin, Michon, Pauline, Künzel, Steffen E, Camporez, Joao Paulo, Singh, Abhishek K, Fong, Guo-Hua, Simons, Michael, Tso, Patrick, Fernández-Hernando, Carlos, Shulman, Gerald I, Sessa, William C, Eichmann, Anne

“…Excess dietary lipid uptake causes obesity, a major global health problem. Enterocyte-absorbed lipids are packaged into chylomicrons, which enter the…”
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SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2 by Ola, Roxana, Künzel, Sandrine H., Zhang, Feng, Genet, Gael, Chakraborty, Raja, Pibouin-Fragner, Laurence, Martin, Kathleen, Sessa, William, Dubrac, Alexandre, Eichmann, Anne

“…Hereditary hemorrhagic telangiectasia (HHT) is an inherited vascular disorder that causes arteriovenous malformations (AVMs). Mutations in the genes encoding…”
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Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization by Rama, Nicolas, Dubrac, Alexandre, Mathivet, Thomas, Ní Chárthaigh, Róisín-Ana, Genet, Gael, Cristofaro, Brunella, Pibouin-Fragner, Laurence, Ma, Le, Eichmann, Anne, Chédotal, Alain

“…Slit ligand–Robo receptor signaling is needed for developmental angiogenesis in the retina and represents a therapeutic target in ocular neovascular diseases…”
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PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia by Ola, Roxana, Dubrac, Alexandre, Han, Jinah, Zhang, Feng, Fang, Jennifer S., Larrivée, Bruno, Lee, Monica, Urarte, Ana A., Kraehling, Jan R., Genet, Gael, Hirschi, Karen K., Sessa, William C., Canals, Francesc V., Graupera, Mariona, Yan, Minhong, Young, Lawrence H., Oh, Paul S., Eichmann, Anne

“…Activin receptor-like kinase 1 (ALK1) is an endothelial serine–threonine kinase receptor for bone morphogenetic proteins (BMPs) 9 and 10. Inactivating…”
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Endothelial cell cycle state determines propensity for arterial-venous fate by Chavkin, Nicholas W., Genet, Gael, Poulet, Mathilde, Jeffery, Erin D., Marziano, Corina, Genet, Nafiisha, Vasavada, Hema, Nelson, Elizabeth A., Acharya, Bipul R., Kour, Anupreet, Aragon, Jordon, McDonnell, Stephanie P., Huba, Mahalia, Sheynkman, Gloria M., Walsh, Kenneth, Hirschi, Karen K.

“…During blood vessel development, endothelial cells become specified toward arterial or venous fates to generate a circulatory network that provides nutrients…”
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The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization by Zhang, Feng, Prahst, Claudia, Mathivet, Thomas, Pibouin-Fragner, Laurence, Zhang, Jiasheng, Genet, Gael, Tong, Raymond, Dubrac, Alexandre, Eichmann, Anne

“…Vascular permeability and neovascularization are implicated in many diseases including retinopathies and diabetic wound healing. Robo4 is an…”
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Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization by Dubrac, Alexandre, Genet, Gael, Ola, Roxana, Zhang, Feng, Pibouin-Fragner, Laurence, Han, Jinah, Zhang, Jiasheng, Thomas, Jean-Léon, Chedotal, Alain, Schwartz, Martin A, Eichmann, Anne

“…BACKGROUND—Sprouting angiogenesis is a key process driving blood vessel growth in ischemic tissues and an important drug target in a number of diseases,…”
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Characterization of protein isoform diversity in human umbilical vein endothelial cells via long-read proteogenomics by Mehlferber, Madison M., Jeffery, Erin D., Saquing, Jamie, Jordan, Ben T., Sheynkman, Leon, Murali, Mayank, Genet, Gael, Acharya, Bipul R., Hirschi, Karen K., Sheynkman, Gloria M.

“…Endothelial cells (ECs) comprise the lumenal lining of all blood vessels and are critical for the functioning of the cardiovascular system. Their phenotypes…”
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Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone by Genet, Nafiisha, Genet, Gael, Chavkin, Nicholas W., Paila, Umadevi, Fang, Jennifer S., Vasavada, Hema H., Goldberg, Joshua S., Acharya, Bipul R., Bhatt, Neha S., Baker, Kasey, McDonnell, Stephanie P., Huba, Mahalia, Sankaranarayanan, Danya, Ma, Gerry Z.M., Eichmann, Anne, Thomas, Jean-Leon, ffrench-Constant, Charles, Hirschi, Karen K.

“…The subventricular zone (SVZ) is the largest neural stem cell (NSC) niche in the adult brain; herein, the blood-brain barrier is leaky, allowing direct…”
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Atomic force and electron microscopic-based study of sarcolemmal surface of living cardiomyocytes unveils unexpected mitochondrial shift in heart failure by Dague, Etienne, Genet, Gaël, Lachaize, Véronique, Guilbeau-Frugier, Céline, Fauconnier, Jérémy, Mias, Céline, Payré, Bruno, Chopinet, Louise, Alsteens, David, Kasas, Sandor, Severac, Childerick, Thireau, Jérôme, Heymes, Christophe, Honton, Benjamin, Lacampagne, Alain, Pathak, Atul, Sénard, Jean-Michel, Galés, Céline

“…Abstract Loss of T-tubules (TT), sarcolemmal invaginations of cardiomyocytes (CMs), was recently identified as a general heart failure (HF) hallmark. However,…”
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Adult resident cardiomyocytes wake up: new axis for cardiac tissue regeneration by Mias, Céline, Genet, Gaël, Pathak, Atul, Sénard, Jean-Michel, Galés, Céline

“…All cardiomyopathies and more specifically myocardial infarction always evolve to cardiomyocytes death and the ensuing heart failure setting. So far, cardiac…”
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Ephrin-B1 regulates the adult diastolic function through a late postnatal maturation of cardiomyocyte surface crests by Karsenty, Clement, Guilbeau-Frugier, Celine, Genet, Gaël, Seguelas, Marie-Helene, Alzieu, Philippe, Cazorla, Olivier, Montagner, Alexandra, Blum, Yuna, Dubroca, Caroline, Maupoint, Julile, Tramunt, Blandine, Cauquil, Marie, Sulpice, Thierry, Richard, Sylvain, Arcucci, Silvia, Flores-Flores, Remy, Pataluch, Nicolas, Montoriol, Romain, Sicard, Pierre, Deney, Antoine, Couffinhal, Thierry, Senard, Jean-Michel, Galés, Celine

“…The rod-shaped adult cardiomyocyte (CM) harbors a unique architecture of its lateral surface with periodic crests, relying on the presence of subsarcolemmal…”
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MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis by Wu, Yinyu, Paila, Umadevi, Genet, Gael, Hirschi, Karen K.

“…Embryonic definitive hematopoiesis generates hematopoietic stem and progenitor cells (HSPCs) that are essential for the establishment and maintenance of the…”
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Ephrin-B1 Is a Novel Specific Component of the Lateral Membrane of the Cardiomyocyte and Is Essential for the Stability of Cardiac Tissue Architecture Cohesion by Genet, Gaël, Guilbeau-Frugier, Céline, Honton, Benjamin, Dague, Etienne, Schneider, Michael D, Coatrieux, Christelle, Calise, Denis, Cardin, Christelle, Nieto, Cécile, Payré, Bruno, Dubroca, Caroline, Marck, Pauline, Heymes, Christophe, Dubrac, Alexandre, Arvanitis, Dina, Despas, Fabien, Altié, Marie-Françoise, Seguelas, Marie-Hélène, Delisle, Marie-Bernadette, Davy, Alice, Sénard, Jean-Michel, Pathak, Atul, Galés, Céline

“…RATIONALE:Cardiac tissue cohesion relying on highly ordered cardiomyocytes (CM) interactions is critical because most cardiomyopathies are associated with…”
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Cardiac fibroblasts regulate sympathetic nerve sprouting and neurocardiac synapse stability by Mias, Céline, Coatrieux, Christelle, Denis, Colette, Genet, Gaël, Seguelas, Marie-Hélène, Laplace, Nathalie, Rouzaud-Laborde, Charlotte, Calise, Denis, Parini, Angelo, Cussac, Daniel, Pathak, Atul, Sénard, Jean-Michel, Galés, Céline

“…Sympathetic nervous system (SNS) plays a key role in cardiac homeostasis and its deregulations always associate with bad clinical outcomes. To date, little is…”
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Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia by Genet, Gael, Genet, Nafiisha, Paila, Umadevi, Cain, Shelby R, Cwiek, Aleksandra, Chavkin, Nicholas W, Serbulea, Vlad, Figueras, Agnès, Cerdà, Pau, McDonnell, Stephanie P, Sankaranarayanan, Danya, Huba, Mahalia, Nelson, Elizabeth A, Riera-Mestre, Antoni, Hirschi, Karen K

“…Distinct endothelial cell cycle states (early G1 versus late G1) provide different "windows of opportunity" to enable the differential expression of genes that…”
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SMAD4 prevents flow induced arterial-venous malformations by inhibiting Casein Kinase 2 by Ola, Roxana, Künzel, Sandrine H, Zhang, Feng, Genet, Gael, Chakraborty, Raja, Pibouin-Fragner, Laurence, Martin, Kathleen, Sessa, William, Dubrac, Alexandre, Eichmann, Anne

“…BACKGROUND:Hereditary Hemorrhagic Telangiectasia (HHT) is an inherited vascular disorder that causes arterial-venous malformations (AVMs). Mutations in the…”
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Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neo-Vascularization by Dubrac, Alexandre, Genet, Gael, Ola, Roxana, Zhang, Feng, Pibouin-Fragner, Laurence, Han, Jinah, Zhang, Jiasheng, Thomas, Jean-Léon, Chedotal, Alain, Schwartz, Martin A., Eichmann, Anne

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