Search Results - "Genes and immunity"

The aging gut microbiome and its impact on host immunity by Bosco, Nabil, Noti, Mario

“…The microbiome plays a fundamental role in the maturation, function, and regulation of the host-immune system from birth to old age. In return, the immune…”
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Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics by Demeure, Christian E., Dussurget, Olivier, Mas Fiol, Guillem, Le Guern, Anne-Sophie, Savin, Cyril, Pizarro-Cerdá, Javier

“…Plague is a vector-borne disease caused by Yersinia pestis . Transmitted by fleas from rodent reservoirs, Y. pestis emerged <6000 years ago from an enteric…”
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Gene–environment interactions and their impact on human health by Virolainen, Samuel J., VonHandorf, Andrew, Viel, Kenyatta C. M. F., Weirauch, Matthew T., Kottyan, Leah C.

“…The molecular processes underlying human health and disease are highly complex. Often, genetic and environmental factors contribute to a given disease or…”
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Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders by Slominski, Radomir M., Tuckey, Robert C., Manna, Pulak R., Jetten, Anton M., Postlethwaite, Arnold, Raman, Chander, Slominski, Andrzej T.

“…Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being delivered to the inner membrane of mitochondria by StAR and…”
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TMEM173 variants and potential importance to human biology and disease by Patel, Seema, Jin, Lei

“…TMEM173 gene encodes the protein STING (stimulator of interferon genes), a key player in host defense against pathogens. Mutations in the human TMEM173 gene…”
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Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients by Mantovani, Stefania, Daga, Sergio, Fallerini, Chiara, Baldassarri, Margherita, Benetti, Elisa, Picchiotti, Nicola, Fava, Francesca, Gallì, Anna, Zibellini, Silvia, Bruttini, Mirella, Palmieri, Maria, Croci, Susanna, Amitrano, Sara, Alaverdian, Diana, Capitani, Katia, Furini, Simone, Mari, Francesca, Meloni, Ilaria, Frullanti, Elisa, Mondelli, Mario U., Renieri, Alessandra

“…Toll-like receptors (TLR) are crucial components in the initiation of innate immune responses to a variety of pathogens, triggering the production of…”
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Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β by Palomares, O, Martín-Fontecha, M, Lauener, R, Traidl-Hoffmann, C, Cavkaytar, O, Akdis, M, Akdis, C A

“…The prevalence of allergic diseases has significantly increased in industrialized countries. Allergen-specific immunotherapy (AIT) remains as the only curative…”
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IRF7: activation, regulation, modification and function by Ning, S, Pagano, J S, Barber, G N

“…Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial…”
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Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: diagnosis, genetics, pathophysiology and treatment by Ravelli, A, Grom, A A, Behrens, E M, Cron, R Q

“…Macrophage activation syndrome (MAS) is a severe, frequently fatal complication of systemic juvenile idiopathic arthritis (sJIA) with features of…”
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Emergence and significance of carbohydrate-specific antibodies by Kappler, Katharina, Hennet, Thierry

“…Carbohydrate-specific antibodies are widespread among all classes of immunoglobulins. Despite their broad occurrence, little is known about their formation and…”
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Revisiting steroidogenesis and its role in immune regulation with the advanced tools and technologies by Chakraborty, Soura, Pramanik, Jhuma, Mahata, Bidesh

“…Historically tools and technologies facilitated scientific discoveries. Steroid hormone research is not an exception. Unfortunately, the dramatic advancement…”
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Evolution and function of interleukin-4 receptor signaling in adaptive immunity and neutrophils by Heeb, Lukas E. M., Egholm, Cecilie, Boyman, Onur

“…The cytokines interleukin (IL)-4 and IL-13, signaling via the IL-4 receptor (IL-4R), orchestrate type 2 immunity to helminth infections and toxins. Activation…”
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The genetics of macrophage activation syndrome by Schulert, Grant S., Cron, Randy Q.

“…Macrophage activation syndrome (MAS), or secondary hemophagocytic lymphohistiocytosis (HLH), is a cytokine storm syndrome associated with multi-organ system…”
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Immunoglobulin germline gene variation and its impact on human disease by Mikocziova, Ivana, Greiff, Victor, Sollid, Ludvig M.

“…Immunoglobulins (Ig) play an important role in the immune system both when expressed as antigen receptors on the cell surface of B cells and as antibodies…”
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Role of DAMPs in respiratory virus-induced acute respiratory distress syndrome—with a preliminary reference to SARS-CoV-2 pneumonia by Land, Walter Gottlieb

“…When surveying the current literature on COVID-19, the “cytokine storm” is considered to be pathogenetically involved in its severe outcomes such as acute…”
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Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes by Miller, F W, Chen, W, O'Hanlon, T P, Cooper, R G, Vencovsky, J, Rider, L G, Danko, K, Wedderburn, L R, Lundberg, I E, Pachman, L M, Reed, A M, Ytterberg, S R, Padyukov, L, Selva-O'Callaghan, A, Radstake, T R, Isenberg, D A, Chinoy, H, Ollier, W E R, Scheet, P, Peng, B, Lee, A, Byun, J, Lamb, J A, Gregersen, P K, Amos, C I

“…Autoimmune muscle diseases (myositis) comprise a group of complex phenotypes influenced by genetic and environmental factors. To identify genetic risk factors…”
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Mechanisms of microbe-immune system dialogue within the skin by Lunjani, Nonhlanhla, Ahearn-Ford, Sinead, Dube, Felix S., Hlela, Carol, O’Mahony, Liam

“…The prevalence and severity of dermatological conditions such as atopic dermatitis have increased dramatically during recent decades. Many of the factors…”
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Predicting the response of the dental pulp to SARS-CoV2 infection: a transcriptome-wide effect cross-analysis by Galicia, Johnah C., Guzzi, Pietro H., Giorgi, Federico M., Khan, Asma A.

“…Pulpitis, inflammation of the dental pulp, is a disease that often necessitates emergency dental care. While pulpitis is considered to be a microbial disease…”
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Immunogenic cell death and its therapeutic or prognostic potential in high-grade glioma by Decraene, Brecht, Yang, Yihan, De Smet, Frederik, Garg, Abhishek D., Agostinis, Patrizia, De Vleeschouwer, Steven

“…Immunogenic cell death (ICD) has emerged as a key component of therapy-induced anti-tumor immunity. Over the past few years, ICD was found to play a pivotal…”
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Human gene expression profiles of susceptibility and resistance in tuberculosis by Maertzdorf, J, Repsilber, D, Parida, S K, Stanley, K, Roberts, T, Black, G, Walzl, G, Kaufmann, S H E

“…Tuberculosis (TB) still poses a profound burden on global health, owing to significant morbidity and mortality worldwide. Although a fully functional immune…”
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