Search Results - "Genes & diseases"

Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics by Anand, Uttpal, Dey, Abhijit, Chandel, Arvind K. Singh, Sanyal, Rupa, Mishra, Amarnath, Pandey, Devendra Kumar, De Falco, Valentina, Upadhyay, Arun, Kandimalla, Ramesh, Chaudhary, Anupama, Dhanjal, Jaspreet Kaur, Dewanjee, Saikat, Vallamkondu, Jayalakshmi, Pérez de la Lastra, José M.

“…Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions of deaths every…”
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Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis by Feng, Yixiao, Spezia, Mia, Huang, Shifeng, Yuan, Chengfu, Zeng, Zongyue, Zhang, Linghuan, Ji, Xiaojuan, Liu, Wei, Huang, Bo, Luo, Wenping, Liu, Bo, Lei, Yan, Du, Scott, Vuppalapati, Akhila, Luu, Hue H., Haydon, Rex C., He, Tong-Chuan, Ren, Guosheng

“…As the most commonly occurring cancer in women worldwide, breast cancer poses a formidable public health challenge on a global scale. Breast cancer consists of…”
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The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases by Zinatizadeh, Mohammad Reza, Schock, Bettina, Chalbatani, Ghanbar Mahmoodi, Zarandi, Peyman Kheirandish, Jalali, Seyed Amir, Miri, Seyed Rouhollah

“…The nuclear factor kappa B (NF-kB) family of transcription factors plays an essential role as stressors in the cellular environment, and controls the…”
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Emergence of antibiotic resistance Pseudomonas aeruginosa in intensive care unit; a critical review by Pachori, Preeti, Gothalwal, Ragini, Gandhi, Puneet

“…The emergence of antibiotic resistant bacteria in the healthcare is a serious concern. In the Healthcare premises precisely intensive care unit are major…”
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Advances in the early diagnosis of hepatocellular carcinoma by Wang, Weiyi, Wei, Chao

“…Hepatocellular carcinoma (HCC) is one of the most prevalent cancers globally. In contrast to the declining death rates observed for all other common cancers…”
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Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy by Deng, Yanhui, Qiao, Lifeng, Du, Mingyan, Qu, Chao, Wan, Ling, Li, Jie, Huang, Lulin

“…Age-related macular degeneration (AMD) is a complex eye disorder and is the leading cause of incurable blindness worldwide in the elderly. Clinically, AMD…”
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Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine by Lee, Cody S., Bishop, Elliot S., Zhang, Ruyi, Yu, Xinyi, Farina, Evan M., Yan, Shujuan, Zhao, Chen, Zeng, Zongyue, Shu, Yi, Wu, Xingye, Lei, Jiayan, Li, Yasha, Zhang, Wenwen, Yang, Chao, Wu, Ke, Wu, Ying, Ho, Sherwin, Athiviraham, Aravind, Lee, Michael J., Wolf, Jennifer Moriatis, Reid, Russell R., He, Tong-Chuan

“…With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology, it is anticipated that…”
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CCL5/CCR5 axis in human diseases and related treatments by Zeng, Zhen, Lan, Tianxia, Wei, Yuquan, Wei, Xiawei

“…To defense harmful stimuli or maintain the immune homeostasis, the body produces and recruits a superfamily of cytokines such as interleukins, interferons,…”
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Immunogenic effects of chemotherapy-induced tumor cell death by Wang, Yi-Jun, Fletcher, Rochelle, Yu, Jian, Zhang, Lin

“…Emerging evidence suggests that the clinical success of conventional chemotherapy is not solely attributed to tumor cell toxicity, but also results from the…”
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DNA methylation in human diseases by Jin, Zelin, Liu, Yun

“…Even though the importance of epigenetics was first recognized in light of its role in tissue development, an increasing amount of evidence has shown that it…”
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Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats by Hou, Yongying, Wang, Ke, Wan, Weijun, Cheng, Yue, Pu, Xia, Ye, Xiufeng

“…Ischemic stroke is a common disease with high mortality and morbidity worldwide. One of the important pathophysiological effects of ischemic stroke is…”
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Emerging roles of lncRNAs in the post-transcriptional regulation in cancer by He, Rong-Zhang, Luo, Di-Xian, Mo, Yin-Yuan

“…Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal role in regulation of diverse cellular processes. In particular, lncRNAs…”
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Targeting matrix metalloproteinases in cancer: Bringing new life to old ideas by Cathcart, Jillian, Pulkoski-Gross, Ashleigh, Cao, Jian

“…Since the identification of matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, as being a driving factor for cancer progression and…”
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Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: Implications in lipid metabolic disorders by Yang, Zhou, Yu, Guang-li, Zhu, Xiao, Peng, Tian-hong, Lv, Yun-cheng

“…The goal this review is to clarify the effects of the fat mass and obesity-associated protein (FTO) in lipid metabolism regulation and related underlying…”
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Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance by Mohammed, Maryam K., Shao, Connie, Wang, Jing, Wei, Qiang, Wang, Xin, Collier, Zachary, Tang, Shengli, Liu, Hao, Zhang, Fugui, Huang, Jiayi, Guo, Dan, Lu, Minpeng, Liu, Feng, Liu, Jianxiang, Ma, Chao, Shi, Lewis L., Athiviraham, Aravind, He, Tong-Chuan, Lee, Michael J.

“…Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,…”
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Epigenetic mechanisms as a new approach in cancer treatment: An updated review by Fardi, Masoumeh, Solali, Saeed, Farshdousti Hagh, Majid

“…Epigenetic, along with genetic mechanisms, is essential for natural evolution and maintenance of specific patterns of gene expression in mammalians. Global…”
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The biogenesis and secretion of exosomes and multivesicular bodies (MVBs): Intercellular shuttles and implications in human diseases by Xu, Minxue, Ji, Jie, Jin, Dandan, Wu, Yue, Wu, Tong, Lin, Renjie, Zhu, Shengze, Jiang, Feng, Ji, Yifei, Bao, Baijun, Li, Mei, Xu, Weisong, Xiao, Mingbing

“…Exosomes carry and transmit signaling molecules used for intercellular communication. The generation and secretion of exosomes is a multistep interlocking…”
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Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: Current status in clinical trials by Song, Yanlin, Bi, Zhenfei, Liu, Yu, Qin, Furong, Wei, Yuquan, Wei, Xiawei

“…Molecular target inhibitors have been regularly approved by Food and Drug Administration (FDA) for tumor treatment, and most of them intervene in tumor cell…”
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The critical roles of m6A modification in metabolic abnormality and cardiovascular diseases by Zhang, Beijian, Jiang, Hao, Dong, Zhen, Sun, Aijun, Ge, Junbo

“…N6-methyladenosine (m6A) RNA methylation is an emerging area of epigenetics, which is a reversible and dynamic modification mediating by ‘writers’ (methylase,…”
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NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation by Liu, Xiaoguang, Zhang, Yilei, Zhuang, Li, Olszewski, Kellen, Gan, Boyi

“…Cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11; also known as xCT) plays a key role in antioxidant defense by mediating cystine…”
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