Search Results - "Genes & cancer"

The promising immune checkpoint LAG-3: from tumor microenvironment to cancer immunotherapy by Long, Long, Zhang, Xue, Chen, Fuchun, Pan, Qi, Phiphatwatchara, Pronnaphat, Zeng, Yuyang, Chen, Honglei

“…Cancer immunotherapy and tumor microenvironment have been at the forefront of research over the past decades. Targeting immune checkpoints especially…”
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Vascular Endothelial Growth Factor (VEGF) and Its Receptor (VEGFR) Signaling in Angiogenesis: A Crucial Target for Anti- and Pro-Angiogenic Therapies by Shibuya, Masabumi

“…The vascular endothelial growth factor (VEGF) and its receptor (VEGFR) have been shown to play major roles not only in physiological but also in most…”
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Role of p38 MAP Kinase Signal Transduction in Solid Tumors by Koul, Hari K, Pal, Mantu, Koul, Sweaty

“…Mitogen-activated protein kinases (MAPKs) mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the main subgroups, the p38…”
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Hypoxia-induced angiogenesis: good and evil by Krock, Bryan L, Skuli, Nicolas, Simon, M Celeste

“…The vascular network delivers oxygen (O(2)) and nutrients to all cells within the body. It is therefore not surprising that O(2) availability serves as a…”
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Ras in cancer and developmental diseases by Fernández-Medarde, Alberto, Santos, Eugenio

“…Somatic, gain-of-function mutations in ras genes were the first specific genetic alterations identified in human cancer about 3 decades ago. Studies during the…”
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis by Rivlin, Noa, Brosh, Ran, Oren, Moshe, Rotter, Varda

“…Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis. In most cases, the p53 gene is mutated, giving rise to a stable mutant protein…”
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Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications by Shvartsur, Anna, Bonavida, Benjamin

“…Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many…”
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DNA methylation: superior or subordinate in the epigenetic hierarchy? by Jin, Bilian, Li, Yajun, Robertson, Keith D

“…Epigenetic modifications are heritable changes in gene expression not encoded by the DNA sequence. In the past decade, great strides have been made in…”
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RAS Interaction with PI3K: More Than Just Another Effector Pathway by Castellano, Esther, Downward, Julian

“…RAS PROTEINS ARE SMALL GTPASES KNOWN FOR THEIR INVOLVEMENT IN ONCOGENESIS: around 25% of human tumors present mutations in a member of this family. RAS…”
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Mitogen-activated protein kinases and their role in radiation response by Munshi, Anupama, Ramesh, Rajagopal

“…Ionizing radiation, like a variety of other cellular stress factors, can activate or down-regulate multiple signaling pathways, leading to either increased…”
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Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer by Kogure, Takayuki, Yan, Irene K, Lin, Wen-Lang, Patel, Tushar

“…Although the expression of long noncoding RNA (lncRNA) is altered in hepatocellular cancer (HCC), their biological effects are poorly defined. We have…”
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The ERK Cascade: Distinct Functions within Various Subcellular Organelles by Wortzel, Inbal, Seger, Rony

“…The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is a central signaling pathway that regulates a wide variety of stimulated cellular processes,…”
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Desmoplasia in pancreatic ductal adenocarcinoma: insight into pathological function and therapeutic potential by Cannon, Andrew, Thompson, Christopher, Hall, Bradley R, Jain, Maneesh, Kumar, Sushil, Batra, Surinder K

“…Extensive desmoplasia is a prominent feature of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Initially, studies demonstrated that desmoplasia…”
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Li-fraumeni syndrome by Malkin, David

“…Li-Fraumeni syndrome (LFS) is a classic cancer predisposition disorder that is commonly associated with germline mutations of the p53 tumor suppressor gene…”
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The dual role of sirtuins in cancer by Bosch-Presegué, Laia, Vaquero, Alejandro

“…Among the greatest challenges facing organisms is that of detecting and effectively responding to life-threatening environmental changes that are intimately…”
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PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control by Georgescu, Maria-Magdalena

“…The PI3K-Akt pathway is a major survival pathway activated in cancer. Efforts to develop targeted therapies have not been fully successful, mainly because of…”
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Raf family kinases: old dogs have learned new tricks by Matallanas, David, Birtwistle, Marc, Romano, David, Zebisch, Armin, Rauch, Jens, von Kriegsheim, Alexander, Kolch, Walter

“…First identified in the early 1980s as retroviral oncogenes, the Raf proteins have been the objects of intense research. The discoveries 10 years later that…”
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Therapeutic strategies for targeting ras proteins by Gysin, Stephan, Salt, Megan, Young, Amy, McCormick, Frank

“…Ras genes are frequently activated in cancer. Attempts to develop drugs that target mutant Ras proteins have, so far, been unsuccessful. Tumors bearing these…”
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Quantitative methods for assessing drug synergism by Tallarida, Ronald J

“…Two or more drugs that individually produce overtly similar effects will sometimes display greatly enhanced effects when given in combination. When the…”
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Colorectal Neoplasia Differentially Expressed (CRNDE), a Novel Gene with Elevated Expression in Colorectal Adenomas and Adenocarcinomas by Graham, Lloyd D, Pedersen, Susanne K, Brown, Glenn S, Ho, Thu, Kassir, Zena, Moynihan, Audrey T, Vizgoft, Emma K, Dunne, Robert, Pimlott, Letitia, Young, Graeme P, Lapointe, Lawrence C, Molloy, Peter L

“…An uncharacterized gene locus (Chr16:hCG_1815491), now named colorectal neoplasia differentially expressed (gene symbol CRNDE), is activated early in…”
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