Search Results - "Genereux, Joseph C."

Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation by Rainbolt, T. Kelly, Atanassova, Neli, Genereux, Joseph C., Wiseman, R. Luke

“…Stress-regulated signaling pathways protect mitochondrial proteostasis and function from pathologic insults. Despite the importance of stress-regulated…”
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Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments by Shoulders, Matthew D., Ryno, Lisa M., Genereux, Joseph C., Moresco, James J., Tu, Patricia G., Wu, Chunlei, Yates, John R., Su, Andrew I., Kelly, Jeffery W., Wiseman, R. Luke

“…The unfolded protein response (UPR) maintains endoplasmic reticulum (ER) proteostasis through the activation of transcription factors such as XBP1s and ATF6…”
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DNA-Mediated Charge Transport in Redox Sensing and Signaling by Genereux, Joseph C, Boal, Amie K, Barton, Jacqueline K

“…The transport of charge through the DNA base-pair stack offers a route to carry out redox chemistry at a distance. Here we describe characteristics of this…”
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Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation by Plate, Lars, Cooley, Christina B, Chen, John J, Paxman, Ryan J, Gallagher, Ciara M, Madoux, Franck, Genereux, Joseph C, Dobbs, Wesley, Garza, Dan, Spicer, Timothy P, Scampavia, Louis, Brown, Steven J, Rosen, Hugh, Powers, Evan T, Walter, Peter, Hodder, Peter, Wiseman, R Luke, Kelly, Jeffery W

“…Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein…”
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A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans by Baranczak, Aleksandra, Liu, Yu, Connelly, Stephen, Du, Wen-Ge Han, Greiner, Erin R, Genereux, Joseph C, Wiseman, R. Luke, Eisele, Yvonne S, Bradbury, Nadine C, Dong, Jiajia, Noodleman, Louis, Sharpless, K. Barry, Wilson, Ian A, Encalada, Sandra E, Kelly, Jeffery W

“…Fluorogenic probes, due to their often greater spatial and temporal sensitivity in comparison to permanently fluorescent small molecules, represent powerful…”
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Calreticulin surface presentation: a signal for natural killer cells to attack by Castellanos, Jasmine P., Genereux, Joseph C.

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Redox signaling between DNA repair proteins for efficient lesion detection by Boal, Amie K, Genereux, Joseph C, Sontz, Pamela A, Gralnick, Jeffrey A, Newman, Dianne K, Barton, Jacqueline K

“…Base excision repair (BER) enzymes maintain the integrity of the genome, and in humans, BER mutations are associated with cancer. Given the remarkable…”
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Single-Step Charge Transport through DNA over Long Distances by Genereux, Joseph C, Wuerth, Stephanie M, Barton, Jacqueline K

“…Quantum yields for charge transport across adenine tracts of increasing length have been measured by monitoring hole transport in synthetic oligonucleotides…”
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Endoplasmic Reticulum Proteostasis Influences the Oligomeric State of an Amyloidogenic Protein Secreted from Mammalian Cells by Chen, John J, Genereux, Joseph C, Suh, Eul Hyun, Vartabedian, Vincent F, Rius, Bibiana, Qu, Song, Dendle, Maria T A, Kelly, Jeffery W, Wiseman, R Luke

“…Transthyretin (TTR) is a tetrameric serum protein associated with multiple systemic amyloid diseases. In these disorders, TTR aggregates in extracellular…”
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Mapping wild-type and R345W fibulin-3 intracellular interactomes by Hulleman, John D., Genereux, Joseph C., Nguyen, Annie

“…Fibulin-3 (F3) is an important, disulfide-rich, extracellular matrix glycoprotein that has been associated with a number of diseases ranging from cancer to…”
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Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1 by Ryno, Lisa M, Genereux, Joseph C, Naito, Tadasuke, Morimoto, Richard I, Powers, Evan T, Shoulders, Matthew D, Wiseman, R. Luke

“…The heat shock response is an evolutionarily conserved, stress-responsive signaling pathway that adapts cellular proteostasis in response to pathologic insult…”
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Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts by Yu Liu, Lei Tan, Yun, Zhang, Xin, Bhabha, Gira, Ekiert, Damian C., Genereux, Joseph C., Cho, Younhee, Kipnis, Yakov, Bjelic, Sinisa, Baker, David, Kelly, Jeffery W.

“…Although much is known about protein folding in buffers, it remains unclear how the cellular protein homeostasis network functions as a system to partition…”
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Ping-Pong Electron Transfer through DNA by Elias, Benjamin, Genereux, Joseph C, Barton, Jacqueline K

“…Either way: An IrIII complex strongly coupled to a DNA base stack can inject a hole or an electron in DNA upon irradiation (see picture). With strands…”
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Mechanisms for DNA Charge Transport by Genereux, Joseph C, Barton, Jacqueline K

“…Various approaches to DNA charge transport chemistry are discussed. Transport methods include water, ions, and phosphates, among others…”
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ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors by Mesgarzadeh, Jaleh S, Romine, Isabelle C, Smith-Cohen, Ethan M, Grandjean, Julia M D, Kelly, Jeffery W, Genereux, Joseph C, Wiseman, R Luke

“…The extracellular aggregation of destabilized transthyretin (TTR) variants is implicated in the onset and pathogenesis of familial TTR-related amyloid…”
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Distance‐Independent DNA Charge Transport across an Adenine Tract by Augustyn, Katherine E., Genereux, Joseph C., Barton, Jacqueline K.

“…Charging along: DNA‐mediated charge transport across adenine tracts is monitored by using a probe interior to the bridge (N6‐cyclopropyladenine (CPA), shown in…”
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Induced Pluripotent Stem Cell Modeling of Multisystemic, Hereditary Transthyretin Amyloidosis by Leung, Amy, Nah, Shirley K., Reid, Whitney, Ebata, Atsushi, Koch, Clarissa M., Monti, Stefano, Genereux, Joseph C., Wiseman, R. Luke, Wolozin, Benjamin, Connors, Lawreen H., Berk, John L., Seldin, David C., Mostoslavsky, Gustavo, Kotton, Darrell N., Murphy, George J.

“…Familial transthyretin amyloidosis (ATTR) is an autosomal-dominant protein-folding disorder caused by over 100 distinct mutations in the transthyretin (TTR)…”
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Back-Electron Transfer Suppresses the Periodic Length Dependence of DNA-Mediated Charge Transport across Adenine Tracts by Genereux, Joseph C, Augustyn, Katherine E, Davis, Molly L, Shao, Fangwei, Barton, Jacqueline K

“…DNA-mediated charge transport (CT) is exquisitely sensitive to the integrity of the bridging π-stack and is characterized by a shallow distance dependence…”
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Profiling protein targets of cellular toxicant exposure by Genereux, Joseph C

“…Environmental agents of exposure can damage proteins, affecting protein function and cellular protein homeostasis. Specific residues are inherently chemically…”
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Methodologies for Measuring Protein Trafficking across Cellular Membranes by Lyu, Ziqi, Genereux, Joseph C.

“…Nearly all proteins are synthesized in the cytosol. The majority of this proteome must be trafficked elsewhere, such as to membranes, to subcellular…”
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