Search Results - "Gener, Petra"

Extracellular Vesicles as Drug Delivery Systems in Cancer by Hernandez-Oller, Laia, Seras-Franzoso, Joaquin, Andrade, Fernanda, Rafael, Diana, Abasolo, Ibane, Gener, Petra, Schwartz, Jr, Simo

“…Within tumors, Cancer Stem Cell (CSC) subpopulation has an important role in maintaining growth and dissemination while preserving high resistance against…”
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Selectively Targeting Breast Cancer Stem Cells by 8-Quinolinol and Niclosamide by Cámara-Sánchez, Patricia, Díaz-Riascos, Zamira V., García-Aranda, Natalia, Gener, Petra, Seras-Franzoso, Joaquin, Giani-Alonso, Micaela, Royo, Miriam, Vázquez, Esther, Schwartz, Simó, Abasolo, Ibane

“…Cancer maintenance, metastatic dissemination and drug resistance are sustained by cancer stem cells (CSCs). Triple negative breast cancer (TNBC) is the breast…”
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Fluorescent CSC models evidence that targeted nanomedicines improve treatment sensitivity of breast and colon cancer stem cells by Gener, Petra, PhD, Gouveia, Luis Pleno, MSc, Sabat, Guillem Romero, MSc, de Sousa Rafael, Diana Fernandes, MSc, Fort, Núria Bergadà, MSc, Arranja, Alexandra, MSc, Fernández, Yolanda, PhD, Prieto, Rafael Miñana, MSc, Ortega, Joan Sayos, PhD, Arango, Diego, PhD, Abasolo, Ibane, PhD, Videira, Mafalda, PhD, Schwartz, Simo, MD, PhD

“…Abstract To be able to study the efficacy of targeted nanomedicines in marginal population of highly aggressive cancer stem cells (CSC), we have developed a…”
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Biological assessment of self-assembled polymeric micelles for pulmonary administration of insulin by Andrade, Fernanda, MSc, Neves, José das, PhD, Gener, Petra, PhD, Schwartz, Simó, PhD, Ferreira, Domingos, PhD, Oliva, Mireia, PhD, Sarmento, Bruno, PhD

“…Abstract Pulmonary delivery of drugs for both local and systemic action has gained new attention over the last decades. In this work, different amphiphilic…”
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AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells by Rafael, Diana, Gener, Petra, Andrade, Fernanda, Seras-Franzoso, Joaquin, Montero, Sara, Fernández, Yolanda, Hidalgo, Manuel, Arango, Diego, Sayós, Joan, Florindo, Helena F., Abasolo, Ibane, Schwartz, Simó, Videira, Mafalda

“…Development of RNA interference-based therapies with appropriate therapeutic window remains a challenge for advanced cancers. Because cancer stem cells (CSC)…”
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Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells by Gener, Petra, Rafael, Diana, Seras-Franzoso, Joaquin, Perez, Anna, Pindado, Luis Alamo, Casas, Glòria, Arango, Diego, Fernández, Yolanda, Díaz-Riascos, Zamira V, Abasolo, Ibane, Schwartz, Jr, Simó

“…Therapeutic resistance seen in aggressive forms of breast cancer remains challenging for current treatments. More than half of the patients suffer from a…”
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Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells by Abasolo, Ibane, Schwartz, Simó, Sayós, Joan, Montero, Sara, Martínez, Francesc, Rafael, Diana, Andrade, Fernanda, Callejo, Patricia González, Seras-Franzoso, Joaquin, Gener, Petra, Arango, Diego

“…There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly…”
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Rational Design of a siRNA Delivery System: ALOX5 and Cancer Stem Cells as Therapeutic Targets by Rafael, Diana, Andrade, Fernanda, Montero, Sara, Gener, Petra, Seras-Franzoso, Joaquin, Martínez, Francesc, González, Patricia, Florindo, Helena, Arango, Diego, Sayós, Joan, Abasolo, Ibane, Videira, Mafalda, Schwartz Jr, Simó

“…The search for an ideal gene delivery system is a long and laborious process in which several factors from the first idea to final formulation, including main…”
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Zileuton™ loaded in polymer micelles effectively reduce breast cancer circulating tumor cells and intratumoral cancer stem cells by Gener, Petra, Montero, Sara, Xandri-Monje, Helena, Díaz-Riascos, Zamira V., Rafael, Diana, Andrade, Fernanda, Martínez-Trucharte, Francesc, González, Patricia, Seras-Franzoso, Joaquin, Manzano, Albert, Arango, Diego, Sayós, Joan, Abasolo, Ibane, Schwartz, Simo

“…Tumor recurrence, metastatic spread and progressive gain of chemo-resistance of advanced cancers are sustained by the presence of cancer stem cells (CSCs)…”
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Perspectives of nano-carrier drug delivery systems to overcome cancer drug resistance in the clinics by Ulldemolins, Anna, Seras-Franzoso, Joaquin, Andrade, Fernanda, Rafael, Diana, Abasolo, Ibane, Gener, Petra, Schwartz, Jr, Simo

“…Advanced cancer is still considered an incurable disease because of its metastatic spread to distal organs and progressive gain of chemoresistance. Even though…”
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3-year invasive disease-free survival with chemotherapy de-escalation using an 18F-FDG-PET-based, pathological complete response-adapted strategy in HER2-positive early breast cancer (PHERGain): a randomised, open-label, phase 2 trial by Pérez-García, José Manuel, Cortés, Javier, Ruiz-Borrego, Manuel, Colleoni, Marco, Stradella, Agostina, Bermejo, Begoña, Dalenc, Florence, Escrivá-de-Romaní, Santiago, Calvo Martínez, Lourdes, Ribelles, Nuria, Marmé, Frederik, Cortés, Alfonso, Albacar, Cinta, Gebhart, Geraldine, Prat, Aleix, Kerrou, Khaldoun, Schmid, Peter, Braga, Sofia, Di Cosimo, Serena, Gion, Maria, Antonarelli, Gabriele, Popa, Crina, Szostak, Emilia, Alcalá-López, Daniel, Gener, Petra, Rodríguez-Morató, Jose, Mina, Leonardo, Sampayo-Cordero, Miguel, Llombart-Cussac, Antonio

“…PHERGain was designed to assess the feasibility, safety, and efficacy of a chemotherapy-free treatment based on a dual human epidermal growth factor receptor 2…”
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Olaparib monotherapy in advanced triple-negative breast cancer patients with homologous recombination deficiency and without germline mutations in BRCA1/2: The NOBROLA phase 2 study by Cortés, Alfonso, López-Miranda, Elena, Fernández-Ortega, Adela, Carañana, Vicente, Servitja, Sonia, Urruticoechea, Ander, Lema-Roso, Laura, Márquez, Antonia, Lazaris, Alexandros, Alcalá-López, Daniel, Mina, Leonardo, Gener, Petra, Rodríguez-Morató, Jose, Antonarelli, Gabriele, Llombart-Cussac, Antonio, Pérez-García, José, Cortés, Javier

“…To evaluate olaparib in advanced triple negative breast cancer (TNBC) patients with homologous recombination deficiency (HRD) and no germline BRCA1/2 mutations…”
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Efficient EFGR mediated siRNA delivery to breast cancer cells by Cetuximab functionalized Pluronic® F127/Gelatin by Rafael, Diana, Martínez, Francesc, Andrade, Fernanda, Seras-Franzoso, Joaquin, Garcia-Aranda, Natalia, Gener, Petra, Sayós, Joan, Arango, Diego, Abasolo, Ibane, Schwartz, Simó

“…•F127 is efficiently carboxylated through the maleic anhydride method (PM F127:COOH).•Carboxylated F127 is efficiently conjugated with Cetuximab (PM…”
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Extracellular vesicles secreted by triple‐negative breast cancer stem cells trigger premetastatic niche remodeling and metastatic growth in the lungs by González‐Callejo, Patricia, Gener, Petra, Díaz‐Riascos, Zamira V., Conti, Sefora, Cámara‐Sánchez, Patricia, Riera, Roger, Mancilla, Sandra, García‐Gabilondo, Miguel, Peg, Vicente, Arango, Diego, Rosell, Anna, Labernadie, Anna, Trepat, Xavier, Albertazzi, Lorenzo, Schwartz, Simó, Seras‐Franzoso, Joaquin, Abasolo, Ibane

“…Tumor secreted extracellular vesicles (EVs) are potent intercellular signaling platforms. They are responsible for the accommodation of the premetastatic niche…”
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Pluronic F127 micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer by Abu-Serie, Marwa M, Andrade, Fernanda, Cámara-Sánchez, Patricia, Seras-Franzoso, Joaquin, Rafael, Diana, Díaz-Riascos, Zamira V, Gener, Petra, Abasolo, Ibane, Schwartz, Simó

“…Improving the stability and anti-cancer stem cell (CSC) activity of citral, a natural ALDH1A inhibitor. Citral-loaded micelles (CLM) were obtained using…”
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3-year invasive disease-free survival with chemotherapy de-escalation using an 18 F-FDG-PET-based, pathological complete response-adapted strategy in HER2-positive early breast cancer (PHERGain): a randomised, open-label, phase 2 trial by Pérez-García, José Manuel, Cortés, Javier, Ruiz-Borrego, Manuel, Colleoni, Marco, Stradella, Agostina, Bermejo, Begoña, Dalenc, Florence, Escrivá-de-Romaní, Santiago, Calvo Martínez, Lourdes, Ribelles, Nuria, Marmé, Frederik, Cortés, Alfonso, Albacar, Cinta, Gebhart, Geraldine, Prat, Aleix, Kerrou, Khaldoun, Schmid, Peter, Braga, Sofia, Di Cosimo, Serena, Gion, Maria, Antonarelli, Gabriele, Popa, Crina, Szostak, Emilia, Alcalá-López, Daniel, Gener, Petra, Rodríguez-Morató, Jose, Mina, Leonardo, Sampayo-Cordero, Miguel, Llombart-Cussac, Antonio

“…PHERGain was designed to assess the feasibility, safety, and efficacy of a chemotherapy-free treatment based on a dual human epidermal growth factor receptor 2…”
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Optimal [ 18 F]FDG PET/CT Cutoff for Pathologic Complete Response in HER2-Positive Early Breast Cancer Patients Treated with Neoadjuvant Trastuzumab and Pertuzumab in the PHERGain Trial by Gebhart, Geraldine, Keyaerts, Marleen, Guiot, Thomas, Flamen, Patrick, Ruiz-Borrego, Manuel, Stradella, Agostina, Bermejo, Begoña, Escriva-de-Romani, Santiago, Calvo Martínez, Lourdes, Ribelles, Nuria, Fernandez-Abad, María, Albacar, Cinta, Colleoni, Marco, Garrigos, Laia, Atienza de Frutos, Manuel, Dalenc, Florence, Prat, Aleix, Marmé, Frederik, Schmid, Peter, Kerrou, Khaldoun, Braga, Sofia, Gener, Petra, Sampayo-Cordero, Miguel, Cortés, Javier, Pérez-García, José Manuel, Llombart-Cussac, Antonio

“…The PHERGain trial investigated the potential of metabolic imaging to identify candidates for chemotherapy deescalation in human epidermal growth factor…”
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The potential of nanomedicine to alter cancer stem cell dynamics: the impact of extracellular vesicles by Gener, Petra, Gonzalez Callejo, Patricia, Seras-Franzoso, Joaquín, Andrade, Fernanda, Rafael, Diana, Abasolo, Ibane, Schwartz, Jr, Simo

“…The presence of highly resistant cancer stem cells (CSCs) within tumors as drivers of metastatic spread has been commonly accepted. Nonetheless, the likelihood…”
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Intracellular targeting of CD44+ cells with self-assembling, protein only nanoparticles by Pesarrodona, Mireia, Ferrer-Miralles, Neus, Unzueta, Ugutz, Gener, Petra, Tatkiewicz, Witold, Abasolo, Ibane, Ratera, Imma, Veciana, Jaume, Jr, Simó Schwartz, Villaverde, Antonio, Vazquez, Esther

“…[Display omitted] CD44 is a multifunctional cell surface protein involved in proliferation and differentiation, angiogenesis and signaling. The expression of…”
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Self-assembly PEGylation assists SLN-paclitaxel delivery inducing cancer cell apoptosis upon internalization by Arranja, Alexandra, Gouveia, Luís F., Gener, Petra, Rafael, Diana F., Pereira, Carolina, Schwartz, Simó, Videira, Mafalda A.

“…[Display omitted] In past years, a considerable progress has been made in the conversion of conventional chemotherapy into potent and safe nanomedicines. The…”
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