Search Results - "Gene"

Alkaline phosphatase: Structure, expression and its function in bone mineralization by Vimalraj, Selvaraj

“…•Bone mineralization is an essential process of life.•ALP is highly expressed in the cells of mineralized tissue.•TNAP hydrolyzes pyrophosphate and supplies…”
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The relation between PI3K/AKT signalling pathway and cancer by Noorolyai, Saeed, Shajari, Neda, Baghbani, Elham, Sadreddini, Sanam, Baradaran, Behzad

“…Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular signalling in response to the extracellular stimulators. Hyperactivation of…”
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Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome by Gómez, Juan, Albaiceta, Guillermo M., García-Clemente, Marta, López-Larrea, Carlos, Amado-Rodríguez, Laura, Lopez-Alonso, Inés, Hermida, Tamara, Enriquez, Ana I., Herrero, Pablo, Melón, Santiago, Alvarez-Argüelles, Marta E., Boga, José A., Rojo-Alba, Susana, Cuesta-Llavona, Elías, Alvarez, Victoria, Lorca, Rebeca, Coto, Eliecer

“…•The Angiotensin system has been implicated in the pathogenesis of COVID-19.•Functional ACE/ACE2 polymorphisms might contribute to the outcome of…”
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Up-down regulation of HIF-1α in cancer progression by Rashid, Mohsen, Zadeh, Leila Rostami, Baradaran, Behzad, Molavi, Ommoleila, Ghesmati, Zeinab, Sabzichi, Mehdi, Ramezani, Fatemeh

“…•HIF-1α stimulate cancer progression through angiogenesis, metastasis, cell proliferation and metabolism alternation process.•HIF-1α has important role during…”
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Krüppel-like factor 4 (KLF4): What we currently know by Ghaleb, Amr M., Yang, Vincent W.

“…Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell…”
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Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis by Li, Ting, Tan, Ying, Ouyang, Shao, He, Jin, Liu, Lingling

“…•Resveratrol protects against myocardial I/R injury.•Res protects against myocardial I/R injury via reducing oxidative stress and attenuating ferroptosis…”
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From delta to Omicron: S1-RBD/S2 mutation/deletion equilibrium in SARS-CoV-2 defined variants by Papanikolaou, Vasileios, Chrysovergis, Aris, Ragos, Vasileios, Tsiambas, Evangelos, Katsinis, Spyros, Manoli, Arezina, Papouliakos, Sotirios, Roukas, Dimitrios, Mastronikolis, Stylianos, Peschos, Dimitrios, Batistatou, Anna, Kyrodimos, Efthimios, Mastronikolis, Nicholas

“…•SARS-CoV-2 demonstrates a continuous tendency for new variants emergence.•Differences in those variants regarding their mutations/deletions/insertions in…”
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Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer by Soleimani, Atena, Rahmani, Farzad, Ferns, Gordon A., Ryzhikov, Mikhail, Avan, Amir, Hassanian, Seyed Mahdi

“…•Over-activation of the NF-κB pathway is a feature of CRC.•Suppression of the NF-κB signaling pathway is a potential therapeutic approach in the treatment of…”
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Crucial players in glycolysis: Cancer progress by Abbaszadeh, Zaka, Çeşmeli, Selin, Biray Avcı, Çığır

“…•Since there is no exact cure discovered for cancer, studies have focused on different hallmarks of cancer.•Warburg’s hypothesis has been a step for the…”
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N6-methyladenosine METTL3 promotes the breast cancer progression via targeting Bcl-2 by Wang, Hong, Xu, Bei, Shi, Jun

“…N6-methyladenosine (m6A) is the most prevalent internal modification in mammalian mRNAs and methyltransferase-like 3 (METTL3) is a vital methyltransferase in…”
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MYH9: Structure, functions and role of non-muscle myosin IIA in human disease by Pecci, Alessandro, Ma, Xuefei, Savoia, Anna, Adelstein, Robert S.

“…The MYH9 gene encodes the heavy chain of non-muscle myosin IIA, a widely expressed cytoplasmic myosin that participates in a variety of processes requiring the…”
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Determining the Polymorphism Information Content of a molecular marker by Serrote, Caetano Miguel Lemos, Reiniger, Lia Rejane Silveira, Silva, Karol Buuron, Rabaiolli, Silvia Machado dos Santos, Stefanel, Charlene Moro

“…•PIC measures molecular markers’ quality for genetic analyses.•There are several equations for PIC calculation.•We propose a simplified equation for PIC…”
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Genetic implications in the pathogenesis of rheumatoid arthritis; an updated review by Karami, Jafar, Aslani, Saeed, Jamshidi, Ahmadreza, Garshasbi, Masoud, Mahmoudi, Mahdi

“…Three important factors, including genetics, environment factors and autoimmunity play a role in the pathogenesis of rheumatoid arthritis (RA). The…”
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SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype by Yamamoto, Naoki, Ariumi, Yasuo, Nishida, Nao, Yamamoto, Rain, Bauer, Georg, Gojobori, Takashi, Shimotohno, Kunitada, Mizokami, Masashi

“…•COVID-19 infection is characterized by its prominent effect on specific ethnic group.•SARS-CoV-2 cases/mortality were negatively associated with ACE1 II…”
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Cancer stem cells: A brief review of the current status by Kuşoğlu, Alican, Biray Avcı, Çığır

“…Cancer stem cells (CSCs) comprise the subpopulation of tumor bulk and acquire resistant to conventional therapies and are considered as the primary tumor…”
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FBN1: The disease-causing gene for Marfan syndrome and other genetic disorders by Sakai, Lynn Y., Keene, Douglas R., Renard, Marjolijn, De Backer, Julie

“…FBN1 encodes the gene for fibrillin-1, a structural macromolecule that polymerizes into microfibrils. Fibrillin microfibrils are morphologically distinctive…”
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Histone H3 lysine 4 methyltransferase KMT2D by Froimchuk, Eugene, Jang, Younghoon, Ge, Kai

“…Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and MLL2 in humans and Mll4 in mice, belongs to a family of mammalian histone H3 lysine 4…”
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Epithelial sodium channel (ENaC) family: Phylogeny, structure–function, tissue distribution, and associated inherited diseases by Hanukoglu, Israel, Hanukoglu, Aaron

“…The epithelial sodium channel (ENaC) is composed of three homologous subunits and allows the flow of Na+ ions across high resistance epithelia, maintaining…”
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HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum by Wang, Jie, Lee, Jessica, Liem, David, Ping, Peipei

“…The HSPA5 gene encodes the binding immunoglobulin protein (BiP), an Hsp70 family chaperone localized in the ER lumen. As a highly conserved molecular…”
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Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis by Kaur, Simran J., McKeown, Stephanie R., Rashid, Shazia

“…Amyotrophic lateral sclerosis (ALS) is a neural disorder that causes death of the motor neurons in the brain and spinal cord; this affects the voluntary…”
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