Search Results - "Gendelman, HE"

Suppression of Inflammatory Neurotoxins by Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus—Associated Dementia by Gendelman, Howard E., Zheng, Jialin, Coulter, Cynthia L., Ghorpade, Anuja, Che, Myhanh, Thylin, Michael, Rubocki, Ronald, Persidsky, Yuri, Hahn, Francis, Reinhard, John, Swindells, Susan

“…A human immunodeficiency virus type 1 (HIV)—seropositive, antiretroviral-naive patient presented with significant cognitive dysfunction. Neuropsychologic,…”
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Nanomedicine in the diagnosis and therapy of neurodegenerative disorders by Kabanov, A.V., Gendelman, H.E.

“…Neurodegenerative and infectious disorders including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as…”
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Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson’s disease by Reynolds, Ashley D., Banerjee, Rebecca, Liu, Jianou, Gendelman, Howard E., Lee Mosley, R.

“…Progressive loss of dopaminergic neurons in the substantia nigra pars compacta and their terminal connections in the striatum are central features in…”
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Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice by DASH, Prasanta K, GENDELMAN, Howard E, ROY, Upal, BALKUNDI, Shantanu, ALNOUTI, Yazen, MOSLEY, Rodney L, GELBARD, Harris A, MCMILLAN, Joellyn, GORANTLA, Santhi, POLUEKTOVA, Larisa Y

“…Long-acting nanoformulated antiretroviral therapy (nanoART) with improved pharmacokinetics, biodistribution and limited systemic toxicities will likely improve…”
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Innate and adaptive immunity for the pathobiology of Parkinson's disease by Stone, David K, Reynolds, Ashley D, Mosley, R Lee, Gendelman, Howard E

“…Innate and adaptive immunity affect the pathogenesis of Parkinson's disease (PD). In particular, activation of microglia influences degeneration of…”
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HIV-1 infection and AIDS: consequences for the central nervous system by Kaul, M, Zheng, J, Okamoto, S, Gendelman, H E, Lipton, S A

“…Infection with the human immunodeficiency virus-1 (HIV-1) can induce severe and debilitating neurological problems that include behavioral abnormalities, motor…”
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Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection by Persidsky, Yuri, Gendelman, Howard E.

“…Human immunodeficiency virus type 1 (HIV‐1)‐associated dementia is a neuroinflammatory brain disorder that is fueled by viral infection and immune activation…”
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Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation by Ibrahim, Ibrahim M, Bade, Aditya N, Lin, Zhiyi, Soni, Dhruvkumar, Wojtkiewicz, Melinda, Dyavar Shetty, Bhagya Laxmi, Gautam, Nagsen, McMillan, JoEllyn M, Alnouti, Yazen, Edagwa, Benson J, Gendelman, Howard E

“…A palmitoylated prodrug of emtricitabine (FTC) was synthesized to extend the drug's half-life, antiretroviral activities and biodistribution. A modified FTC…”
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Therapeutic Immunization Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease by Benner, Eric J., Mosley, R. Lee, Destache, Chris J., Lewis, Travis B., Jackson-Lewis, Vernice, Gorantla, Santhi, Nemachek, Craig, Green, Steven R., Przedborski, Serge, Gendelman, Howard E., Bloom, Floyd E.

“…Degeneration of the nigrostriatal dopaminergic pathway, the hallmark of Parkinson's disease, can be recapitulated in…”
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Neural Immunity: Friend or Foe? by Gendelman, Howard E

“…The articles compiled in this special edition of Journal of NeuroVirology target a developing field of investigation seeking to uncover how the immune system…”
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Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis by Potula, Raghava, Poluektova, Larisa, Knipe, Bryan, Chrastil, Jesse, Heilman, David, Dou, Huanyu, Takikawa, Osamu, Munn, David H., Gendelman, Howard E., Persidsky, Yuri

“…Indoleamine 2,3-dioxygenase (IDO) is the rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism. IDO activity is linked with immunosuppression…”
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Investigating the human immunodeficiency virus type 1-infected monocyte-derived macrophage secretome by Ciborowski, Pawel, Kadiu, Irena, Rozek, Wojciech, Smith, Lynette, Bernhardt, Kristen, Fladseth, Melissa, Ricardo-Dukelow, Mary, Gendelman, Howard E

“…Abstract Mononuclear phagocytes (bone marrow monocyte-derived macrophages, alveolar macrophages, perivascular macrophages, and microglia) are reservoirs and…”
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Overexpression of Monocyte Chemotactic Protein-1/CCL2 in β-Amyloid Precursor Protein Transgenic Mice Show Accelerated Diffuse β-Amyloid Deposition by Yamamoto, Masaru, Horiba, Masahide, Buescher, James L., Huang, DeReng, Gendelman, Howard E., Ransohoff, Richard M., Ikezu, Tsuneya

“…Microglia accumulation at the site of amyloid plaques is a strong indication that microglia play a major role in Alzheimer's disease pathogenesis. However, how…”
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Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human monocyte-derived macrophages by Dou, Huanyu, Morehead, Justin, Destache, Christopher J, Kingsley, Jeffrey D, Shlyakhtenko, Lyudmila, Zhou, You, Chaubal, Mahesh, Werling, Jane, Kipp, James, Rabinow, Barrett E, Gendelman, Howard E

“…Abstract The effectiveness of anti-retroviral therapies (ART) depends on its ultimate ability to clear reservoirs of continuous human immunodeficiency virus…”
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CD 4+ T cells in the pathobiology of neurodegenerative disorders by Huang, Xiuyan, Reynolds, Ashley D, Mosley, R. Lee, Gendelman, Howard E

“…Abstract CD4+ T cells orchestrate innate and adaptive immunity. In the central nervous system they modulate immune responses including cell trafficking and…”
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Anti-retroviral nanoformulations for enhancing CNS drug delivery by Gendelman, HE

“…The elimination of the human immunodeficiency virus inside its central nervous system (CNS) sanctuary is affected by variable antiretroviral therapy (ART)…”
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Magnetic resonance imaging of folic acid-coated magnetite nanoparticles reflects tissue biodistribution of long-acting antiretroviral therapy by Li, Tianyuzi, Gendelman, Howard E, Zhang, Gang, Puligujja, Pavan, McMillan, JoEllyn M, Bronich, Tatiana K, Edagwa, Benson, Liu, Xin-Ming, Boska, Michael D

“…Regimen adherence, systemic toxicities, and limited drug penetrance to viral reservoirs are obstacles limiting the effectiveness of antiretroviral therapy…”
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HIV-1-Associated Dementia: A Metabolic Encephalopathy Perpetrated by Virus-Infected and Immune-Competent Mononuclear Phagocytes by Anderson, Eric, Zink, Walter, Xiong, Huangui, Gendelman, Howard E

“…Infection of the nervous system by HIV-1 commonly causes a broad range of cognitive, behavioral, and motor abnormalities called, in its most severe form,…”
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Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells by Kanmogne, Georgette D, Singh, Sangya, Roy, Upal, Liu, Xinming, McMillan, Joellyn, Gorantla, Santhi, Balkundi, Shantanu, Smith, Nathan, Alnouti, Yazen, Gautam, Nagsen, Zhou, You, Poluektova, Larisa, Kabanov, Alexander, Bronich, Tatiana, Gendelman, Howard E

“…Despite the successes of antiretroviral therapy (ART), HIV-associated neurocognitive disorders remain prevalent in infected people. This is due, in part, to…”
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Memantine Protects Hippocampal Neuronal Function in Murine Human Immunodeficiency Virus Type 1 Encephalitis by Anderson, Eric R, Gendelman, Howard E, Xiong, Huangui

“…Memantine, a low-to-moderate-affinity NMDA receptor antagonist, can be used to treat cognitive impairment associated with Alzheimer's disease. However, its…”
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