Search Results - "Genain, Claude"

Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosis by Menge, Til, Lalive, Patrice H, von Büdingen, H Christian, Genain, Claude P

“…Myelin/oligodendrocyte glycoprotein (MOG) is a putative autoantigen in multiple sclerosis (MS). Establishing the pathological relevance and validity of…”
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Antibodies to Native Myelin Oligodendrocyte Glycoprotein Are Serologic Markers of Early Inflammation in Multiple Sclerosis by Lalive, Patrice H., Menge, Til, Delarasse, Cecile, Gaspera, Bruno Della, Pham-Dinh, Danielle, Villoslada, Pablo, von Büdingen, H. -C., Genain, Claude P.

“…Myelin oligodendrocyte glycoprotein (MOG) is an integral membrane protein expressed in CNS oligodendrocytes and outermost myelin lamellae. Anti-MOG Abs cause…”
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Frontline: Epitope recognition on the myelin/oligodendrocyte glycoprotein differentially influences disease phenotype and antibody effector functions in autoimmune demyelination by von Büdingen, Hans‐Christian, Hauser, Stephen L., Ouallet, Jean‐Christophe, Tanuma, Naoyuki, Menge, Til, Genain, Claude P.

“…Preliminary observations of humoral immunity against the myelin oligodendrocyte glycoprotein (MOG) in experimental allergic encephalomyelitis (EAE) and human…”
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Identification of autoantibodies associated with myelin damage in multiple sclerosis by Genain, Claude P, Cannella, Barbara, Hauser, Stephen L, Raine, Cedric S

“…The molecular mechanisms underlying myelin sheath destruction in multiple sclerosis lesions remain unresolved. With immunogold-labeled peptides of myelin…”
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Transient increases in anti-aquaporin-4 antibody titers following rituximab treatment in neuromyelitis optica, in association with elevated serum BAFF levels by Nakashima, Ichiro, Takahashi, Toshiyuki, Cree, Bruce A.C, Kim, Ho Jin, Suzuki, Chihiro, Genain, Claude P, Vincent, Thierry, Fujihara, Kazuo, Itoyama, Yasuto, Bar-Or, Amit

“…Abstract Rituximab is increasingly used for prevention of relapses of neuromyelitis optica (NMO), a condition that is highly associated with serum…”
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Role of nerve growth factor and other trophic factors in brain inflammation by Villoslada, Pablo, Genain, Claude P

“…Inflammation in the brain is a double-edged process that may be beneficial in promoting homeostasis and repair, but can also result in tissue injury through…”
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Relevant antibody subsets against MOG recognize conformational epitopes exclusively exposed in solid-phase ELISA by Menge, Til, von Büdingen, Hans-Christian, Lalive, Patrice H, Genain, Claude P

“…A pathogenic role for circulating anti-myelin antibodies is difficult to establish in multiple sclerosis (MS). Here, we unravel a broad heterogeneity within…”
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Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis by Robinson, William H, Fontoura, Paulo, Lee, Byung J, de Vegvar, Henry E Neuman, Tom, Jennifer, Pedotti, Rosetta, DiGennaro, Carla D, Mitchell, Dennis J, Fong, Derek, Ho, Peggy P-K, Ruiz, Pedro J, Maverakis, Emanual, Stevens, David B, Bernard, Claude C A, Martin, Roland, Kuchroo, Vijay K, van Noort, Johannes M, Genain, Claude P, Amor, Sandra, Olsson, Tomas, Utz, Paul J, Garren, Hideki, Steinman, Lawrence

“…The diversity of autoimmune responses poses a formidable challenge to the development of antigen-specific tolerizing therapy. We developed 'myelin proteome'…”
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Antibody responses against galactocerebroside are potential stage-specific biomarkers in multiple sclerosis by Menge, Til, Lalive, Patrice H., von Büdingen, Hans-Christian, Cree, Bruce, Hauser, Stephen L., Genain, Claude P.

“…Galactocerebroside, the major glycolipid of central nervous system myelin, is a known target for pathogenic demyelinating antibody responses in experimental…”
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Synergistic Interactions of Lipids and Myelin Basic Protein by Hu, Yufang, Doudevski, Ivo, Wood, Denise, Moscarello, Mario, Husted, Cynthia, Genain, Claude, Zasadzinski, Joseph A., Israelachvili, Jacob

“…This report describes force measurements and atomic force microscope imaging of lipid-protein interactions that determine the structure of a model membrane…”
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Experimental allergic encephalomyelitis in the New World monkey Callithrix jacchus by Genain, Claude P., Hauser, Stephen L.

“…Models that adequately reflect the complexity of human multiple sclerosis (MS) are needed, especially for preclinical testing of immunomodulatory drugs. Our…”
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Molecular Characterization of Antibody Specificities against Myelin/Oligodendrocyte Glycoprotein in Autoimmune Demyelination by von Büdingen, Hans-Christian, Hauser, Stephen L., Fuhrmann, Antje, Nabavi, Cameron B., Lee, Joy I., Genain, Claude P.

“…Myelin/oligodendrocyte glycoprotein (MOG) is a target antigen for myelin-destructive Abs in autoimmune central nervous system demyelinating disorders. Little…”
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Apoptotic effects of Human Herpesvirus-6A on glia and neurons as potential triggers for central nervous system autoimmunity by Gardell, Jennifer L., Dazin, Paul, Islar, Janeen, Menge, Til, Genain, Claude P., Lalive, Patrice H.

“…Human Herpesvirus type 6 (HHV-6A and/or HHV-6B) has been tentatively associated with multiple sclerosis (MS). However, there is currently no direct proof of…”
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Poly(ADP-ribose) polymerase-1 activation in a primate model of multiple sclerosis by Kauppinen, Tiina M., Suh, Sang Won, Genain, Claude P., Swanson, Raymond A.

“…Multiple sclerosis (MS) is an immune‐mediated disabling neurological disorder involving inflammation, demyelination, axonal damage, and neurodegeneration…”
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Late Complications of Immune Deviation Therapy in a Nonhuman Primate by Genain, Claude P., Abel, Kristina, Belmar, Nicole, Villinger, Francois, Rosenberg, Daniel P., Linington, Christopher, Raine, Cedric S., Hauser, Stephen L.

“…The administration of antigens in soluble form can induce antigen-specific immune tolerance and suppress experimental autoimmune diseases. In a marmoset model…”
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Role of lipid interactions in autoimmune demyelination by Ohler, Benjamin, Graf, Karlheinz, Bragg, Richard, Lemons, Travis, Coe, Robert, Genain, Claude, Israelachvili, Jacob, Husted, Cynthia

“…A morphological transformation involving loss of adhesion between myelin lamellae and formation of myelin vesicles has been described as a mechanism for…”
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Revisiting Tolerance Induced by Autoantigen in Incomplete Freund's Adjuvant by Heeger, Peter S, Forsthuber, Thomas, Shive, Carey, Biekert, Earla, Genain, Claude, Hofstetter, Harald H, Karulin, Alexey, Lehmann, Paul V

“…Injection of autoantigens in IFA has been one of the most effective ways of preventing experimental, T cell-mediated, autoimmune disease in mice. The mechanism…”
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Autoreactivity to myelin antigens: myelin/oligodendrocyte glycoprotein is a prevalent autoantigen by Diaz-Villoslada, Pablo, Shih, Andrew, Shao, Ling, Genain, Claude P, Hauser, Stephen L

“…Autoreactive T cells specific for myelin antigens are thought to play a role in the pathogenesis of multiple sclerosis (MS). We compared T cell proliferative…”
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The Human T Cell Response to Myelin Oligodendrocyte Glycoprotein: A Multiple Sclerosis Family-Based Study by Koehler, Niklas K. U, Genain, Claude P, Giesser, Barbara, Hauser, Stephen L

“…Myelin oligodendrocyte glycoprotein (MOG) is an encephalitogenic myelin protein and a likely autoantigen in human multiple sclerosis (MS). In this work, we…”
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Specific immunotherapy: One size does not fit all by Genain, Claude P, Zamvil, Scott S

“…Two clinical trials testing an altered peptide ligand (APL) in multiple sclerosis report seemingly contradictory results. Immunologic analysis shows that the…”
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