Search Results - "Genain, C"

An open label study of the effects of rituximab in neuromyelitis optica by CREE, B. A. C, LAMB, S, MORGAN, K, CHEN, A, WAUBANT, E, GENAIN, C

“…Eight patients with worsening neuromyelitis optica were treated with rituximab to achieve B cell depletion. Treatment was well tolerated. Six of eight patients…”
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Activity of a newly identified serine protease in CNS demyelination by SCARISBRICK, I. A, BLABER, S. I, LUCCHINETTI, C. F, GENAIN, C. P, BLABER, M, RODRIGUEZ, M

“…We have identified a novel serine protease, myelencephalon-specific protease (MSP), which is preferentially expressed in the adult CNS, and therein, is…”
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Identification of new serum autoantibodies in neuromyelitis optica using protein microarrays by LALIVE, P. H, MENGE, T, BARMAN, I, CREE, B. A, GENAIN, C. P

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Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: A case for antigen-specific antibody mediation by Raine, Cedric S., Cannella, Barbara, Hauser, Stephen L., Genain, Claude P.

“…Neuropathological and ultrastructural features of central nervous system demyelination were compared in marmoset experimental autoimmune encephalomyelitis…”
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Late Complications of Immune Deviation Therapy in a Nonhuman Primate by Genain, Claude P., Abel, Kristina, Belmar, Nicole, Villinger, Francois, Rosenberg, Daniel P., Linington, Christopher, Raine, Cedric S., Hauser, Stephen L.

“…The administration of antigens in soluble form can induce antigen-specific immune tolerance and suppress experimental autoimmune diseases. In a marmoset model…”
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Identification of autoantibodies associated with myelin damage in multiple sclerosis by Genain, Claude P, Cannella, Barbara, Hauser, Stephen L, Raine, Cedric S

“…The molecular mechanisms underlying myelin sheath destruction in multiple sclerosis lesions remain unresolved. With immunogold-labeled peptides of myelin…”
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Creation of a model for multiple sclerosis in Callithrix jacchus marmosets by GENAIN, C. P, HAUSER, S. L

“…Multiple sclerosis (MS) is an inflammatory disease of the CNS white matter characterized pathologically by the accumulation of perivascular and parenchymal T…”
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Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous system by Villoslada, P, Hauser, S L, Bartke, I, Unger, J, Heald, N, Rosenberg, D, Cheung, S W, Mobley, W C, Fisher, S, Genain, C P

“…Multiple sclerosis is a demyelinating disorder of the central nervous system (CNS), in which an immune attack directed against myelin constituents causes…”
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Role of nerve growth factor and other trophic factors in brain inflammation by Villoslada, Pablo, Genain, Claude P

“…Inflammation in the brain is a double-edged process that may be beneficial in promoting homeostasis and repair, but can also result in tissue injury through…”
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Antibody responses against galactocerebroside are potential stage-specific biomarkers in multiple sclerosis by Menge, Til, Lalive, Patrice H., von Büdingen, Hans-Christian, Cree, Bruce, Hauser, Stephen L., Genain, Claude P.

“…Galactocerebroside, the major glycolipid of central nervous system myelin, is a known target for pathogenic demyelinating antibody responses in experimental…”
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Specific immunotherapy: One size does not fit all by Genain, Claude P, Zamvil, Scott S

“…Two clinical trials testing an altered peptide ligand (APL) in multiple sclerosis report seemingly contradictory results. Immunologic analysis shows that the…”
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Active and passively induced experimental autoimmune encephalomyelitis in common marmosets: a new model for multiple sclerosis by Massacesi, L, Genain, C P, Lee-Parritz, D, Letvin, N L, Canfield, D, Hauser, S L

“…A chronic relapsing-remitting form of experimental autoimmune encephalomyelitis was induced in the common marmoset Callithrix jacchus following a single…”
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3-D echo planar (1)HMRS imaging in MS: metabolite comparison from supratentorial vs. central brain by Pelletier, D, Nelson, S J, Grenier, D, Lu, Y, Genain, C, Goodkin, D E

“…To determine if metabolite ratios as measured by 3-dimensional echo planar spectroscopy imaging (3D-EPSI) from central brain regions of interest (ROI) centered…”
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Experimental allergic encephalomyelitis in the New World monkey Callithrix jacchus by Genain, Claude P., Hauser, Stephen L.

“…Models that adequately reflect the complexity of human multiple sclerosis (MS) are needed, especially for preclinical testing of immunomodulatory drugs. Our…”
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Molecular Characterization of Antibody Specificities against Myelin/Oligodendrocyte Glycoprotein in Autoimmune Demyelination by von Büdingen, Hans-Christian, Hauser, Stephen L., Fuhrmann, Antje, Nabavi, Cameron B., Lee, Joy I., Genain, Claude P.

“…Myelin/oligodendrocyte glycoprotein (MOG) is a target antigen for myelin-destructive Abs in autoimmune central nervous system demyelinating disorders. Little…”
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Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate by Genain, C P, Nguyen, M H, Letvin, N L, Pearl, R, Davis, R L, Adelman, M, Lees, M B, Linington, C, Hauser, S L

“…In the human disease multiple sclerosis (MS), the immune mechanisms responsible for selective destruction of central nervous system myelin are unknown. In the…”
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Characterization of the expressed immunoglobulin IGHV repertoire in the New World marmoset Callithrix jacchus by von Büdingen, H C, Hauser, S L, Nabavi, C B, Genain, C P

“…The common marmoset (Callithrix jacchus jacchus) is a member of the Callithrichinae, a family of outbred New World primates with limited MHC polymorphisms and…”
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Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-ligand and co-stimulatory molecules by Villinger, F, Bostik, P, Mayne, A, King, C L, Genain, C P, Weiss, W R, Ansari, A A

“…The finding that a single administration of select recombinant human cytokines to nonhuman primates leads to potent cytokine-neutralizing antibody responses in…”
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MR imaging investigations in a non-human primate model of multiple sclerosis by Genain, C P

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Frequency, heterogeneity and encephalitogenicity of T cells specific for myelin oligodendrocyte glycoprotein in naive outbred primates by Villoslada, Pablo, Abel, Kristina, Heald, Nathan, Goertsches, Robert, Hauser, Stephen L., Genain, Claude P.

“…Auto‐reactive T cells present in healthy subjects remain in a state of unresponsiveness, but may trigger autoimmunity under various situations. Although myelin…”
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