Search Results - "Genady, Afaf R."

Photoacoustic imaging of a cyanine dye targeting bacterial infection by Swann, Rowan, Hernández-Valdés, Daniel, Silva, Luis Rafael, Marfatia, Yusra Mahmood, El-Zaria, Mohamed E., Genady, Afaf R., Kwiecien, Jacek M., Valliant, John F., Sadeghi, Saman

“…The development of a non-invasive infection-specific diagnostic probe holds the potential to vastly improve early-stage detection of infection, enabling…”
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Promising carboranylquinazolines for boron neutron capture therapy: Synthesis, characterization, and in vitro toxicity evaluation by Genady, Afaf R.

“…Novel classes of structurally different boronated quinazolines were designed bearing 22–37% boron by weight for potential application in BNCT of tumors…”
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New functionalized mercaptoundecahydrododecaborate derivatives for potential application in boron neutron capture therapy: Synthesis, characterization and dynamic visualization in cells by Genady, Afaf R., Ioppolo, Joseph A., Azaam, Mohamed M., El-Zaria, Mohamed E.

“…A series of mercaptoundecahydrododecaborate (B12H11SH2−, BSH) bearing mono- and dicarboxyalkyl derivatives was prepared, characterized, and their reactivity…”
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High Yielding Synthesis of Carboranes Under Mild Reaction Conditions Using a Homogeneous Silver(I) Catalyst: Direct Evidence of a Bimetallic Intermediate by El-Zaria, Mohamed E., Keskar, Kunal, Genady, Afaf R., Ioppolo, Joseph A., McNulty, James, Valliant, John F.

“…Methods used to prepare functionalized carboranes generally require heating to high temperatures, and thus limits the range of derivatives which can be…”
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High Yielding Preparation of Dicarba-closo-dodecaboranes Using a Silver(I) Mediated Dehydrogenative Alkyne-Insertion Reaction by Toppino, Antonio, Genady, Afaf R, El-Zaria, Mohamed E, Reeve, James, Mostofian, Fargol, Kent, Jeff, Valliant, John F

“…The synthesis of 1,2-dicarba-closo-dodecaboranes (ortho-carboranes) is often low yielding which is a critical issue given the increasing use of boron clusters…”
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Correction: A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives by Vito, Alyssa, Alarabi, Hussain, Czorny, Shannon, Beiraghi, Omid, Kent, Jeff, Janzen, Nancy, Genady, Afaf R, Al-Karmi, Salma A, Rathmann, Stephanie, Naperstkow, Zoya, Blacker, Megan, Llano, Lisset, Berti, Paul J, Valliant, John F

“…[This corrects the article DOI: 10.1371/journal.pone.0167425.]…”
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A 99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives by Vito, Alyssa, Alarabi, Hussain, Czorny, Shannon, Beiraghi, Omid, Kent, Jeff, Janzen, Nancy, Genady, Afaf R, Al-Karmi, Salma A, Rathmann, Stephanie, Naperstkow, Zoya, Blacker, Megan, Llano, Lisset, Berti, Paul J, Valliant, John F

“…A convenient strategy to radiolabel a hydrazinonicotonic acid (HYNIC)-derived tetrazine with 99mTc was developed, and its utility for creating probes to image…”
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Pretargeted PET of Osteodestructive Lesions in Dogs by Maitz, Charles A., Delaney, Samantha, Cook, Brendon E., Genady, Afaf R., Hoerres, Rebecca, Kuchuk, Marina, Makris, Georgios, Valliant, John F., Sadeghi, Saman, Lewis, Jason S., Hennkens, Heather M., Bryan, Jeffrey N., Zeglis, Brian M.

“…The last decade has witnessed the creation of a highly effective approach to in vivo pretargeting based on the inverse electron demand Diels–Alder (IEDDA)…”
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Automated synthesis of [18F]DCFPyL via direct radiofluorination and validation in preclinical prostate cancer models by Bouvet, Vincent, Wuest, Melinda, Jans, Hans-Soenke, Janzen, Nancy, Genady, Afaf R., Valliant, John F., Benard, Francois, Wuest, Frank

“…Background Prostate-specific membrane antigen (PSMA) is frequently overexpressed and upregulated in prostate cancer. To date, various 18 F- and 68 Ga-labeled…”
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A Versatile Platform for the Development of Radiolabeled Antibody-Recruiting Small Molecules by Rathmann, Stephanie M, Genady, Afaf R, Janzen, Nancy, Anipindi, Varun, Czorny, Shannon, Rullo, Anthony F, Sadeghi, Saman, Valliant, John F

“…Building on clinical case reports of the abscopal effect, there has been considerable interest in the synergistic effects of radiation and immunotherapies for…”
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Preparation and Evaluation of Radiolabeled Antibody Recruiting Small Molecules That Target Prostate-Specific Membrane Antigen for Combined Radiotherapy and Immunotherapy by Genady, Afaf R, Janzen, Nancy, Banevicius, Laura, El-Gamal, Mahmoud, El-Zaria, Mohamed E, Valliant, John F

“…The feasibility of developing a single agent that can deliver radioactive iodine and also direct cellular immune function by engaging endogenous antibodies as…”
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Novel glycosylated carboranylquinazolines for boron neutron capture therapy of tumors: synthesis, characterization, and in vitro toxicity studies by Genady, Afaf R., El-Zaria, Mohamed E.

“…The synthesis of a series of N‐glycosyl caboranylquinazolines is described. The condensation reaction of nitro‐acetylanthranilic acid with aminophenylcarborane…”
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Azanonaboranes Containing Imidazole Derivatives for Boron Neutron Capture Therapy: Synthesis, Characterization, and In Vitro Toxicity Evaluation by El-Zaria, Mohamed E., Genady, Afaf R., Gabel, Detlef

“…A number of azanonaboranes containing imidazole derivatives have been synthesized by a ligand‐exchange reaction. The exo‐NH2R group of the azanonaborane of the…”
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Amphiphilic allylation of arylidene-1,3-oxazol-5(4H)-one using bis-π-allylpalladium complexes: an approach to synthesis of cyclohexyl and cyclohexenyl α-amino acids by Genady, Afaf R, Nakamura, Hiroyuki

“…An efficient method for synthesis of cyclohexyl and cyclohexenyl α-amino acids via palladium-catalyzed three-component assemblies followed by ring-closing…”
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Preparation and evaluation of carborane-derived inhibitors of prostate specific membrane antigen (PSMA) by El-Zaria, Mohamed E, Genady, Afaf R, Janzen, Nancy, Petlura, Christina I, Beckford Vera, Denis R, Valliant, John F

“…A series of C-hydroxy carborane derivatives of (S)-2-(3-((S)-5-amino-1-carboxypentyl)ureido)-pentanedioic acid were prepared as a new class of boron rich…”
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High Yielding Synthesis of Carboranes Under Mild Reaction Conditions Using a Homogeneous Silver(I) Catalyst: Direct Evidence of a Bimetallic Intermediate by El-Zaria, Mohamed E., Keskar, Kunal, Genady, Afaf R., Ioppolo, Joseph A., McNulty, James, Valliant, John F.

“…Methods used to prepare functionalized carboranes generally require heating to high temperatures, and thus limits the range of derivatives which can be…”
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Fluorous Analogue of Chloramine-T: Preparation, X‑ray Structure Determination, and Use as an Oxidant for Radioiodination and s‑Tetrazine Synthesis by Dzandzi, James P. K, Beckford Vera, Denis R, Genady, Afaf R, Albu, Silvia A, Eltringham-Smith, Louise J, Capretta, Alfredo, Sheffield, William P, Valliant, John F

“…A fluorous oxidant that can be used to introduce radioiodine into small molecules and proteins and generate iodinated tetrazines for bioorthogonal chemistry…”
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Labeled Undecahydro-closo-dodecaborates Based on Azo Dyes for Boron Neutron Capture Therapy: Synthesis, Characterization, and Visualization in Cells by Genady, Afaf R

“…A general approach to the synthesis of novel boronated azo dyes derived from undecahydro-closo-dodecaborates as a convenient preparation of dye labeled for…”
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A bioorthogonal methylene blue derived probe for targeted photoacoustic imaging by Genady, Afaf R., Slikboer, Samantha R., Swann, Rowan, Wyszatko, Kevin, Janzen, Nancy, Silva, Luis Rafael, El-Zaria, Mohamed E., Sadeghi, Saman, Valliant, John F.

“…Photoacoustic (PA) imaging is a nonradioactive and noninvasive imaging modality that can volumetrically map the distribution of photo-absorbing molecules with…”
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A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using 99mTc- and 177Lu-Labeled Tetrazines by Yazdani, Abdolreza, Bilton, Holly, Vito, Alyssa, Genady, Afaf R, Rathmann, Stephanie M, Ahmad, Zainab, Janzen, Nancy, Czorny, Shannon, Zeglis, Brian M, Francesconi, Lynn C, Valliant, John F

“…A high yield synthesis of a novel, small molecule, bisphosphonate-modified trans-cyclooctene (TCO-BP, 2) that binds to regions of active bone metabolism and…”
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