Search Results - "Gemmer, Jennifer"

MK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cells by Kreahling, Jenny M, Gemmer, Jennifer Y, Reed, Damon, Letson, Douglas, Bui, Marilyn, Altiok, Soner

“…Wee1 is a critical component of the G(2)-M cell-cycle checkpoint control and mediates cell-cycle arrest by regulating the phosphorylation of CDC2. Inhibition…”
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The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells by Fu, Wei, Ma, Le, Chu, Baoky, Wang, Xue, Bui, Marilyn M, Gemmer, Jennifer, Altiok, Soner, Pledger, W Jackson

“…Although rare, osteosarcoma is an aggressive cancer that often metastasizes to the lungs. Toward the goal of developing new treatment options for osteosarcoma,…”
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Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells by Brazelle, William, Kreahling, Jenny M, Gemmer, Jennifer, Ma, Yihong, Cress, W Douglas, Haura, Eric, Altiok, Soner

“…Histone deacetylase inhibitors (HDACis) are promising anticancer drugs; however, the molecular mechanisms leading to HDACi-induced cell death have not been…”
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Impact of the immunoglobulin heavy chain variable region mutational status in patients with low risk chronic lymphocytic leukemia by Gemmer, Jennifer, MPH, Rock-Klotz, Jennifer, Corrales-Yepez, Gabriela, Pinilla-Ibarz, Javier, Chavez, Julio

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Abstract 4892: PYK2 mediates microenvironment-specific myeloma survival by Meads, Mark B., Fang, Bin, Mathews, Linda, Gemmer, Jennifer, Nong, Liang, MacCleod, Robert, Hazlehurst, Lori, Koomen, John, Shain, Kenneth H.

“…Abstract Multiple myeloma remains an incurable malignancy due to the influence of the bone marrow microenvironment on survival, drug response, and resultant…”
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PYK2 Mediates Microenvironment-Specific Myeloma Survival by Meads, Mark, Fang, Bin, Mathews, Linda, Gemmer, Jennifer, Nong, Liang, Hazlehurst, Lori A, MacLeod, Robert, Koomen, John, Shain, Kenneth

“…Multiple myeloma remains an incurable bone marrow resident malignancy due to the eventual development of drug resistance and minimal residual disease linked to…”
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Pyk2 Mediates Enhanced STAT3 Phosphorylation Following Collaborative Signaling Between gp130 and beta1 Integrins in Adhered Myeloma Cells by Shain, Kenneth, Meads, Mark, Nong, Liang, Gemmer, Jennifer, Mathews, Linda, Fang, Bin, MacLeod, Robert, Koomen, John

“…Abstract 4021 Multiple myeloma remains an incurable bone marrow resident malignancy, in part, due to the eventual development of drug resistance linked to both…”
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Targeting PYK2 Mediates Microenvironment-Specific Myeloma Cell Death by Meads, Mark B, Fang, Bin, Mathews, Linda, Gemmer, Jennifer, Nong, Liang, Rosado-Lopez, Ismael, Nguyen, Tuan, Ring, Jennifer E., Matsui, William, MacLeod, Robert, Weaver, David T., Pachter, Jonathan A., Hazlehurst, Lori A., Koomen, John M., Shain, Kenneth H.

“…Multiple myeloma (MM) remains an all but incurable malignancy due to minimal residual disease (MRD). MRD is influenced by the survival promoting aspects of the…”
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Targeting PYK2 Mediates Microenvironment-Specific Myeloma Cell Death by Shain, Kenneth H., Meads, Mark B, Fang, Bin, Mathews, Linda, Gemmer, Jennifer, Nong, Liang, Rosado-Lopez, Ismael, Ring, Jennifer E., MacLeod, Robert, Hazlehurst, Lori, Lynch, Conor, Pachter, Jonathan A., Matsui, William, Koomen, John, Nguyen, Tuan

“…Multiple myeloma (MM) remains an incurable malignancy, at least in part, due to minimal residual disease (MRD). It has been hypothesized that MRD is influenced…”
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Abstract 4381: EGFR-Src signaling regulates self-renewal of cancer stem like cells from NSCLC through Sox2 by Singh, Sandeep, Trevino, Jose, Laklai, Hanane, Kroeger, Jodi, Gemmer, Jennifer, Coppola, Domenico, Altiok, Soner, Chellappan, Srikumar

“…Abstract NSCLC is the most common form of lung cancer with 5-year survival rate of approximately 10%. Cancer stem cell model has been proposed for…”
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Abstract 3047: MK1775, a selective Wee1 inhibitor shows antitumor activity against sarcoma cells by Kreahling, Jenny M., Foroutan, Parastou, Gemmer, Jennifer Y., Martinez, Gary, Reed, Damon, Letson, Douglas, Bui, Marilyn, Gillies, Rober J., Altiok, Soner

“…Abstract Sarcomas are rare and heterogeneous mesenchymal tumors affecting both pediatric and adult populations with more than 70 recognized histologies…”
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Abstract 5048: Targeting regulators of Chk1 to enhance cytotoxic efficacy of HDAC inhibitors by Kreahling, Jenny M., Gemmer, Jennifer Y., Ma, Yihong, Cress, Douglas, Johnson, Jackie, Chellappan, Srikumar P., Altiok, Soner

“…Abstract Introduction: Predicting and overcoming drug resistance is a major difficulty facing the efficacy of drugs in clinical trials. Histone deacetylase…”
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Differential proinflammatory and angiogenesis-specific cytokine production in human pulmonary endothelial cells, HPMEC-ST1.6R infected with dengue-2 and dengue-3 virus by Azizan, Azliyati, Sweat, James, Espino, Carlos, Gemmer, Jennifer, Stark, Lillian, Kazanis, Deno

“…In this study, the ability of dengue virus serotypes 2 (DENV-2) and 3 (DENV-3) to infect and induce increased production of proinflammatory cytokines in a…”
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Abstract 3596: SCH727965, a cyclin-dependent kinases inhibitor, induces apoptosis in sarcoma cells through caspase 3- dependent pathway by Fu, Wei, Ma, Le, Chu, Baoky, Wang, Xue, Bagui, Tapan K., Bui, Marilyn M., Gemmer, Jennifer, Altiok, Soner, Letson, Douglas G., Pledger, W. Jack

“…Abstract Sarcoma is a rare cancer in adults (1% of all adult cancers), but rather prevalent in children (about 15% of all childhood cancers). Toward the goal…”
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