Prevalence of Cardiovascular Autonomic Neuropathy in a Cohort of Patients With Newly Diagnosed Type 2 Diabetes: The Verona Newly Diagnosed Type 2 Diabetes Study (VNDS)

Prevalence of Cardiovascular Autonomic Neuropathy in a Cohort of Patients With Newly Diagnosed Type 2 Diabetes: The Verona Newly Diagnosed Type 2 Diabetes Study (VNDS)

Cardiovascular autonomic diabetic neuropathy (CAN) is a serious complication of diabetes. No reliable data on the prevalence of CAN among patients with newly diagnosed type 2 diabetes are available. Therefore, the aim of this study was to estimate the prevalence of CAN among patients with newly diag...

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Bibliographic Details
Published in:Diabetes care Vol. 38; no. 8; pp. 1487 - 1493
Main Authors: Zoppini, Giacomo, Cacciatori, Vittorio, Raimondo, Daniele, Gemma, Marialuisa, Trombetta, Maddalena, Dauriz, Marco, Brangani, Corinna, Pichiri, Isabella, Negri, Carlo, Stoico, Vincenzo, Bergamini, Corinna, Targher, Giovanni, Santi, Lorenza, Thomaseth, Karl, Bellavere, Federico, Bonadonna, Riccardo C, Bonora, Enzo
Format: Journal Article
Language:English
Published: United States American Diabetes Association 01-08-2015
Subjects:
Aged
Autonomic Nervous System Diseases - diagnosis
Blood Pressure - physiology
Body mass index
Cardiovascular system
Cholesterol, HDL - blood
Diabetes
Diabetes Mellitus, Type 2 - diagnosis
Diabetic Angiopathies - diagnosis
Diabetic Neuropathies - diagnosis
Diabetic neuropathy
Early Diagnosis
Epidemiologic Methods
Female
Glycated Hemoglobin A - metabolism
Humans
Male
Middle Aged
Multivariate analysis
Neurologic Examination
Regression analysis
Triglycerides - blood
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Summary:Cardiovascular autonomic diabetic neuropathy (CAN) is a serious complication of diabetes. No reliable data on the prevalence of CAN among patients with newly diagnosed type 2 diabetes are available. Therefore, the aim of this study was to estimate the prevalence of CAN among patients with newly diagnosed type 2 diabetes. A cohort of 557 patients with newly diagnosed type 2 diabetes with cardiovascular autonomic test results available was selected. Early and confirmed neuropathy were assessed using a standardized methodology and their prevalences determined. A multivariate logistic regression analysis was modeled to study the factors associated with CAN. In the entire cohort, the prevalence of confirmed CAN was 1.8%, whereas that of early CAN was 15.3%. Prevalence did not differ between men and women. In the multivariate analyses BMI results were independently and significantly associated with CAN after adjusting for age, sex, hemoglobin A1c, pulse pressure, triglyceride-to-HDL cholesterol ratio, kidney function parameters, and antihypertensive treatment. CAN could be detected very early in type 2 diabetes. This study may suggest the importance of performing standardized cardiovascular autonomic tests after diagnosis of type 2 diabetes.
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ISSN:0149-5992
1935-5548
DOI:10.2337/dc15-0081