Burden of Candidemia in the United States, 2017

Abstract Background Candidemia is a common healthcare-associated bloodstream infection with high morbidity and mortality. There are no current estimates of candidemia burden in the United States (US). Methods In 2017, the Centers for Disease Control and Prevention conducted active population-based s...

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Published in:	Clinical infectious diseases Vol. 71; no. 9; pp. e449 - e453
Main Authors:	Tsay, Sharon V, Mu, Yi, Williams, Sabrina, Epson, Erin, Nadle, Joelle, Bamberg, Wendy M, Barter, Devra M, Johnston, Helen L, Farley, Monica M, Harb, Sasha, Thomas, Stepy, Bonner, Lindsay A, Harrison, Lee H, Hollick, Rosemary, Marceaux, Kaytlynn, Mody, Rajal K, Pattee, Brittany, Shrum Davis, Sarah, Phipps, Erin C, Tesini, Brenda L, Gellert, Anita B, Zhang, Alexia Y, Schaffner, William, Hillis, Sherry, Ndi, Danielle, Graber, Caroline R, Jackson, Brendan R, Chiller, Tom, Magill, Shelley, Vallabhaneni, Snigdha
Format:	Journal Article
Language:	English
Published:	US Oxford University Press 03-12-2020
Subjects:	Adult Aged Candida Candidemia - epidemiology Cross Infection Humans Incidence Male Population Surveillance United States - epidemiology United States communicable diseases candidemia healthcare-associated infections Candida
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Summary:	Abstract Background Candidemia is a common healthcare-associated bloodstream infection with high morbidity and mortality. There are no current estimates of candidemia burden in the United States (US). Methods In 2017, the Centers for Disease Control and Prevention conducted active population-based surveillance for candidemia through the Emerging Infections Program in 45 counties in 9 states encompassing approximately 17 million persons (5% of the national population). Laboratories serving the catchment area population reported all blood cultures with Candida, and a standard case definition was applied to identify cases that occurred in surveillance area residents. Burden of cases and mortality were estimated by extrapolating surveillance area cases to national numbers using 2017 national census data. Results We identified 1226 candidemia cases across 9 surveillance sites in 2017. Based on this, we estimated that 22 660 (95% confidence interval [CI], 20 210–25 110) cases of candidemia occurred in the US in 2017. Overall estimated incidence was 7.0 cases per 100 000 persons, with highest rates in adults aged ≥ 65 years (20.1/100 000), males (7.9/100 000), and those of black race (12.3/100 000). An estimated 3380 (95% CI, 1318–5442) deaths occurred within 7 days of a positive Candida blood culture, and 5628 (95% CI, 2465–8791) deaths occurred during the hospitalization with candidemia. Conclusions Our analysis highlights the substantial burden of candidemia in the US. Because candidemia is only one form of invasive candidiasis, the true burden of invasive infections due to Candida is higher. Ongoing surveillance can support future burden estimates and help assess the impact of prevention interventions. Using population-based surveillance that includes 5% of the US population, we estimated that the incidence of candidemia nationally was 7 cases per 100 000 persons and that there were nearly 23 000 cases of candidemia and 3400 deaths in 2017.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1058-4838 1537-6591
DOI:	10.1093/cid/ciaa193