Search Results - "Geller, Herbert M."

Extracellular matrix and traumatic brain injury by George, Naijil, Geller, Herbert M.

“…The brain extracellular matrix (ECM) plays a crucial role in both the developing and adult brain by providing structural support and mediating cell‐cell…”
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Strength in the Periphery: Growth Cone Biomechanics and Substrate Rigidity Response in Peripheral and Central Nervous System Neurons by Koch, Daniel, Rosoff, William J., Jiang, Jiji, Geller, Herbert M., Urbach, Jeffrey S.

“…There is now considerable evidence of the importance of mechanical cues in neuronal development and regeneration. Motivated by the difference in the mechanical…”
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The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development by Mencio, Caitlin P., Hussein, Rowan K., Yu, Panpan, Geller, Herbert M.

“…The orderly development of the nervous system is characterized by phases of cell proliferation and differentiation, neural migration, axonal outgrowth and…”
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Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation by Singh, Komudi, Han, Kim, Tilve, Sharada, Wu, Kaiyuan, Geller, Herbert M., Sack, Michael N

“…Loss of substantia nigra dopaminergic neurons results in Parkinson disease (PD). Degenerative PD usually presents in the seventh decade whereas genetic…”
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NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans by Dickendesher, Travis L, Baldwin, Katherine T, Mironova, Yevgeniya A, Koriyama, Yoshiki, Raiker, Stephen J, Askew, Kim L, Wood, Andrew, Geoffroy, Cédric G, Zheng, Binhai, Liepmann, Claire D, Katagiri, Yasuhiro, Benowitz, Larry I, Geller, Herbert M, Giger, Roman J

“…In this study, the authors show that NgR1 and NgR3 can act as functional receptors for chondroitin sulfate proteoglycans (CSPGs), mediating inhibition of…”
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Correction: A novel cytoskeletal action of xylosides by Mencio, Caitlin P, Tilve, Sharada M, Suzuki, Masato, Higashi, Kyohei, Katagiri, Yasuhiro, Geller, Herbert M

“…[This corrects the article DOI: 10.1371/journal.pone.0269972.]…”
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Role of Chondroitin Sulfation Following Spinal Cord Injury by Hussein, Rowan K., Mencio, Caitlin P., Katagiri, Yasuhiro, Brake, Alexis M., Geller, Herbert M.

“…Traumatic spinal cord injury produces long-term neurological damage, and presents a significant public health problem with nearly 18,000 new cases per year in…”
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Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS by Petrova, Veselina, Pearson, Craig S., Ching, Jared, Tribble, James R., Solano, Andrea G., Yang, Yunfei, Love, Fiona M., Watt, Robert J., Osborne, Andrew, Reid, Evan, Williams, Pete A., Martin, Keith R., Geller, Herbert M., Eva, Richard, Fawcett, James W.

“…Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequences. One approach to…”
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Identification of novel binding sites for heparin in receptor protein-tyrosine phosphatase (RPTPσ): Implications for proteoglycan signaling by Katagiri, Yasuhiro, Morgan, Ashlea A., Yu, Panpan, Bangayan, Nathanael J., Junka, Radoslaw, Geller, Herbert M.

“…Receptor protein-tyrosine phosphatase RPTPσ has important functions in modulating neural development and regeneration. Compelling evidence suggests that both…”
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Identification of a critical sulfation in chondroitin that inhibits axonal regeneration by Pearson, Craig S, Mencio, Caitlin P, Barber, Amanda C, Martin, Keith R, Geller, Herbert M

“…The failure of mammalian CNS neurons to regenerate their axons derives from a combination of intrinsic deficits and extrinsic factors. Following injury,…”
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Astrocytes from the brain microenvironment alter migration and morphology of metastatic breast cancer cells by Shumakovich, Marina A., Mencio, Caitlin P., Siglin, Jonathan S., Moriarty, Rebecca A., Geller, Herbert M., Stroka, Kimberly M.

“…Tumor cell metastasis to the brain involves cell migration through biochemically and physically complex microenvironments at the blood‐brain barrier (BBB). The…”
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A novel cytoskeletal action of xylosides by Mencio, Caitlin P, Tilve, Sharada M, Suzuki, Masato, Higashi, Kohei, Katagiri, Yasuhiro, Geller, Herbert M

“…Proteoglycan glycosaminoglycan (GAG) chains are attached to a serine residue in the protein through a linkage series of sugars, the first of which is xylose…”
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Effect of chondroitin sulfate proteoglycans on neuronal cell adhesion, spreading and neurite growth in culture by Jin, Jingyu, Tilve, Sharada, Huang, Zhonghai, Zhou, Libing, Geller, Herbert, Yu, Panpan

“…As one major component of extracellular matrix （ECM） in the central nervous system, chondroitin sul- fate proteoglycans （CSPGs） have long been known as…”
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Old but not obsolete: an enhanced high-speed immunoblot by Higashi, Sayuri L, Yagyu, Kazuya, Nagase, Haruna, Pearson, Craig S, Geller, Herbert M, Katagiri, Yasuhiro

“…Abstract The immunoblotting technique (also known as western blotting) is an essential tool used in biomedical research to determine the relative size and…”
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Alterations in sulfated chondroitin glycosaminoglycans following controlled cortical impact injury in mice by Yi, Jae-Hyuk, Katagiri, Yasuhiro, Susarla, Bala, Figge, David, Symes, Aviva J., Geller, Herbert M.

“…Chondroitin sulfate proteoglycans (CSPGs) play a pivotal role in many neuronal growth mechanisms including axon guidance and the modulation of repair processes…”
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Chondroitin-4-sulfation negatively regulates axonal guidance and growth by Wang, Hang, Katagiri, Yasuhiro, McCann, Thomas E, Unsworth, Edward, Goldsmith, Paul, Yu, Zu-Xi, Tan, Fei, Santiago, Lizzie, Mills, Edward M, Wang, Yu, Symes, Aviva J, Geller, Herbert M

“…Glycosaminoglycan (GAG) side chains endow extracellular matrix proteoglycans with diversity and complexity based upon the length, composition and charge…”
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Temporal patterns of cortical proliferation of glial cell populations after traumatic brain injury in mice by Susarla, Bala T S, Villapol, Sonia, Yi, Jae-Hyuk, Geller, Herbert M, Symes, Aviva J

“…TBI (traumatic brain injury) triggers an inflammatory cascade, gliosis and cell proliferation following cell death in the pericontusional area and surrounding…”
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Biomimetic Polymer Brushes Containing Tethered Acetylcholine Analogs for Protein and Hippocampal Neuronal Cell Patterning by Zhou, Zhaoli, Yu, Panpan, Geller, Herbert M, Ober, Christopher K

“…This paper describes a method to control neuronal cell adhesion and differentiation with both chemical and topographic cues by using a spatially defined…”
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The potassium channel KCa3.1 constitutes a pharmacological target for astrogliosis associated with ischemia stroke by Yi, Mengni, Wei, Tianjiao, Wang, Yanxia, Lu, Qin, Chen, Gaoxian, Gao, Xiaoling, Geller, Herbert M, Chen, Hongzhuan, Yu, Zhihua

“…Reactive astrogliosis is one of the significantly pathological features in ischemic stroke accompanied with changes in gene expression, morphology, and…”
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Inhibiting Glycosaminoglycan Chain Polymerization Decreases the Inhibitory Activity of Astrocyte-Derived Chondroitin Sulfate Proteoglycans by Laabs, Tracy L, Wang, Hang, Katagiri, Yasuhiro, McCann, Thomas, Fawcett, James W, Geller, Herbert M

“…Chondroitin sulfate proteoglycans (CSPGs) are upregulated in the CNS after injury and participate in the inhibition of axon regeneration mainly through their…”
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