Search Results - "Gell, Laura K"

Within-night repeatability and long-term consistency of sleep apnea endotypes: the Multi-Ethnic Study of Atherosclerosis and Osteoporotic Fractures in Men Study by Alex, Raichel M, Sofer, Tamar, Azarbarzin, Ali, Vena, Daniel, Gell, Laura K, Wellman, Andrew, White, David P, Redline, Susan, Sands, Scott A

“…Abstract Study Objectives Obstructive sleep apnea (OSA) is characterized by multiple “endotypic traits,” including pharyngeal collapsibility, muscle…”
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Neural ventilatory drive decline as a predominant mechanism of obstructive sleep apnoea events by Gell, Laura K, Vena, Daniel, Alex, Raichel M, Azarbarzin, Ali, Calianese, Nicole, Hess, Lauren B, Taranto-Montemurro, Luigi, White, David P, Wellman, Andrew, Sands, Scott A

“…In the classic model of obstructive sleep apnoea (OSA), respiratory events occur with sleep-related dilator muscle hypotonia, precipitating increased neural…”
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A novel method to quantify breathing effort from respiratory mechanics and esophageal pressure by Gell, Laura, Reynolds, Karen J, McEvoy, R Doug, Nguyen, Duc Phuc, Catcheside, Peter G

“…Breathing effort is important to quantify to understand mechanisms underlying central and obstructive sleep apnea, respiratory-related arousals, and the timing…”
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Exaggerated ventilatory drive estimates from epiglottic and esophageal pressure deflections in the presence of airway occlusion by Gell, Laura K., Stadler, Daniel L., Reynolds, Karen J., Catcheside, Peter G.

“…Esophageal and epiglottic pressure deflection measurements are widely used as gold-standard measures of ventilatory effort during sleep without consideration…”
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Drive versus Pressure Contributions to Genioglossus Activity in Obstructive Sleep Apnea by Gell, Laura K, Vena, Daniel, Grace, Kevin, Azarbarzin, Ali, Messineo, Ludovico, Hess, Lauren B, Calianese, Nicole, Labarca, Gonzalo, Taranto-Montemurro, Luigi, White, David P, Wellman, Andrew, Sands, Scott A

“…Loss of pharyngeal dilator muscle activity is a key determinant of respiratory events in obstructive sleep apnea (OSA). After the withdrawal of wakefulness…”
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Atomoxetine and fesoterodine combination improves obstructive sleep apnoea severity in patients with milder upper airway collapsibility by Messineo, Ludovico, Taranto‐Montemurro, Luigi, Calianese, Nicole, Gell, Laura K., Azarbarzin, Ali, Labarca, Gonzalo, Vena, Dan, Yang, Hyung Chae, Wang, Tsai‐Yu, Wellman, Andrew, Sands, Scott A.

“…Background and objective The combination of the noradrenergic atomoxetine plus the anti‐muscarinic oxybutynin acutely increased genioglossus activity and…”
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Pathophysiology Underlying Demographic and Obesity Determinants of Sleep Apnea Severity by Sands, Scott A, Alex, Raichel M, Mann, Dwayne, Vena, Daniel, Terrill, Philip I, Gell, Laura K, Zinchuk, Andrey, Sofer, Tamar, Patel, Sanjay R, Taranto-Montemurro, Luigi, Azarbarzin, Ali, Rueschman, Michael, White, David P, Wellman, Andrew, Redline, Susan

“…Sleep apnea is the manifestation of key endotypic traits, including greater pharyngeal collapsibility, reduced dilator muscle compensation, and elevated…”
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Atomoxetine and fesoterodine combination improves obstructive sleep apnea severity in patients with milder upper airway collapsibility by Messineo, Ludovico, Taranto-Montemurro, Luigi, Calianese, Nicole, Gell, Laura K, Azarbarzin, Ali, Labarca, Gonzalo, Vena, Dan, Yang, Hyung Chae, Wang, Tsai-Yu, Wellman, Andrew, Sands, Scott A

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