Search Results - "Gelin, Muriel"

Small-Molecule Inhibitors of Cyclophilins Block Opening of the Mitochondrial Permeability Transition Pore and Protect Mice From Hepatic Ischemia/Reperfusion Injury by Panel, Mathieu, Ruiz, Isaac, Brillet, Rozenn, Lafdil, Fouad, Teixeira-Clerc, Fatima, Nguyen, Cong Trung, Calderaro, Julien, Gelin, Muriel, Allemand, Fred, Guichou, Jean-François, Ghaleh, Bijan, Ahmed-Belkacem, Abdelhakim, Morin, Didier, Pawlotsky, Jean-Michel

“…Hepatic ischemia/reperfusion injury is a complication of liver surgery that involves mitochondrial dysfunction resulting from mitochondrial permeability…”
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Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities by Ahmed-Belkacem, Abdelhakim, Colliandre, Lionel, Ahnou, Nazim, Nevers, Quentin, Gelin, Muriel, Bessin, Yannick, Brillet, Rozenn, Cala, Olivier, Douguet, Dominique, Bourguet, William, Krimm, Isabelle, Pawlotsky, Jean-Michel, Guichou, Jean- François

“…Cyclophilins are peptidyl-prolyl cis/trans isomerases (PPIase) that catalyse the interconversion of the peptide bond at proline residues. Several cyclophilins…”
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New Chemical Probe Targeting Bacterial NAD Kinase by Clément, David A, Leseigneur, Clarisse, Gelin, Muriel, Coelho, Dylan, Huteau, Valérie, Lionne, Corinne, Labesse, Gilles, Dussurget, Olivier, Pochet, Sylvie

“…Nicotinamide adenine dinucleotide (NAD) kinases are essential and ubiquitous enzymes involved in the tight regulation of NAD/nicotinamide adenine dinucleotide…”
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Toward the Design of Ligands Selective for the C-Terminal Domain of TEADs by Liberelle, Maxime, Toulotte, Florine, Renault, Nicolas, Gelin, Muriel, Allemand, Frédéric, Melnyk, Patricia, Guichou, Jean-François, Cotelle, Philippe

“…The Hippo signaling pathway plays a fundamental role in the control of organ growth, cell proliferation, and stem cell characters. TEADs are the main…”
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TOWARDS THE DESIGN OF LIGANDS OF THE INTERNAL POCKET TEADS C-TERMINAL DOMAIN by TOULOTTE, Florine, COEVOET, Mathilde, LIBERELLE, Maxime, BAILLY, Fabrice, ZAGIEL, Benjamin, GELIN, Muriel, ALLEMAND, Frédéric, FOURQUET, Patrick, MELNYK, Patricia, Jean-François, G.U.I.C.H.O.U., COTELLE, Philippe

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Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs by Gedeon, Antoine, Ayoub, Nour, Brûlé, Sébastien, Raynal, Bertrand, Karimova, Gouzel, Gelin, Muriel, Mechaly, Ariel, Haouz, Ahmed, Labesse, Gilles, Munier-Lehmann, Hélène

“…Inosine 5'-monophosphate dehydrogenase (IMPDH) is a^ ubiquitous enzyme that catalyzes the NAD+ -dependent oxidation of inosine 5'-monophosphate into xanthosine…”
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Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation by Mary, Charline, Soflaee, Mona Hoseini, Kesavan, Rushendhiran, Gelin, Muriel, Brown, Harrison, Zacharias, G, Mathews, Thomas P, Lemoff, Andrew, Lionne, Corinne, Labesse, Gilles, Hoxhaj, Gerta

“…NAD kinases (NADKs) are metabolite kinases that phosphorylate NAD molecules to make NADP , a limiting substrate for the generation of reducing power NADPH…”
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w TSA-CRAFT : an open-access web server for rapid analysis of thermal shift assay experiments by Reys, Victor, Kowalewski, Julien, Gelin, Muriel, Lionne, Corinne

“…The automated data processing provided by the tool enables now to reach high throughput speed analysis of thermal shift assays. While the software is powerful…”
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wTSA-CRAFT: an open-access web server for rapid analysis of thermal shift assay experiments by Reys, Victor, Kowalewski, Julien, Gelin, Muriel, Lionne, Corinne

“…Abstract Motivation The automated data processing provided by the TSA-CRAFT tool enables now to reach high throughput speed analysis of thermal shift assays…”
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Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases by Gedeon, Antoine, Ayoub, Nour, Brûlé, Sébastien, Raynal, Bertrand, Karimova, Gouzel, Gelin, Muriel, Mechaly, Ariel, Haouz, Ahmed, Labesse, Gilles, Munier‐Lehmann, Hélène

“…Inosine 5′‐monophosphate (IMP) dehydrogenase (IMPDH) is an ubiquitous enzyme that catalyzes the NAD+‐dependent oxidation of inosine 5′‐monophosphate into…”
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Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors by Sturbaut, Manon, Bailly, Fabrice, Coevoet, Mathilde, Sileo, Pasquale, Pugniere, Martine, Liberelle, Maxime, Magnez, Romain, Thuru, Xavier, Chartier-Harlin, Marie-Christine, Melnyk, Patricia, Gelin, Muriel, Allemand, Frédéric, Guichou, Jean-François, Cotelle, Philippe

“…The Hippo pathway is involved in organ size control and tissue homeostasis by regulating cell growth, proliferation and apoptosis. It controls the…”
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Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding by Schneider, Melanie, Delfosse, Vanessa, Gelin, Muriel, Grimaldi, Marina, Granell, Meritxell, Heriaud, Laurène, Pons, Jean-Luc, Cohen Gonsaud, Martin, Balaguer, Patrick, Bourguet, William, Labesse, Gilles

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Structure-Based and Knowledge-Informed Design of B‑Raf Inhibitors Devoid of Deleterious PXR Binding by Schneider, Melanie, Delfosse, Vanessa, Gelin, Muriel, Grimaldi, Marina, Granell, Meritxell, Heriaud, Laurène, Pons, Jean-Luc, Cohen Gonsaud, Martin, Balaguer, Patrick, Bourguet, William, Labesse, Gilles

“…Dabrafenib is an anticancer drug currently used in the clinics, alone or in combination. However, dabrafenib was recently shown to potently activate the human…”
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Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria by Clément, David A., Gelin, Muriel, Leseigneur, Clarisse, Huteau, Valérie, Mondange, Lou, Pons, Jean-Luc, Dussurget, Olivier, Lionne, Corinne, Labesse, Gilles, Pochet, Sylvie

“…Nicotinamide adenine dinucleotide kinases (NAD kinases) are essential and ubiquitous enzymes involved in the production of NADP(H) which is an essential…”
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Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation by Lecointre, Céline, Simon, Valérie, Kerneur, Clément, Allemand, Frédéric, Fournet, Aurélie, Montarras, Ingrid, Pons, Jean-Luc, Gelin, Muriel, Brignatz, Constance, Urbach, Serge, Labesse, Gilles, Roche, Serge

“…The pseudo-kinase and signaling protein Pragmin has been linked to cancer by regulating protein tyrosine phosphorylation via unknown mechanisms. Here we…”
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Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings by Fnaiche, Ahmed, Mélin, Léa, Suárez, Narjara González, Paquin, Alexis, Vu, Victoria, Li, Fengling, Allali-Hassani, Abdellah, Bolotokova, Albina, Allemand, Frédéric, Gelin, Muriel, Cotelle, Philippe, Woo, Simon, LaPlante, Steven R., Barsyte-Lovejoy, Dalia, Santhakumar, Vijayaratnam, Vedadi, Masoud, Guichou, Jean-François, Annabi, Borhane, Gagnon, Alexandre

“…[Display omitted] The Hippo pathway regulates organ size and tissue homeostasis by controlling cell proliferation and apoptosis. The YAP–TEAD transcription…”
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Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding by Schneider, Melanie, Delfosse, Vanessa, Gelin, Muriel, Grimaldi, Marina, Granell, Meritxell, Heriaud, Laurène, Pons, Jean-Luc, Cohen Gonsaud, Martin, Balaguer, Patrick, Bourguet, William, Labesse, Gilles

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First-in-class allosteric inhibitors of bacterial IMPDHs by Alexandre, Thomas, Lupan, Alexandru, Helynck, Olivier, Vichier-Guerre, Sophie, Dugué, Laurence, Gelin, Muriel, Haouz, Ahmed, Labesse, Gilles, Munier-Lehmann, Hélène

“…Inosine-5‘-monophosphate dehydrogenase (IMPDH) is an essential enzyme in many bacterial pathogens and is considered as a potential drug target for the…”
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Structure‐based design, synthesis and biological evaluation of a NAD+ analogue targeting Pseudomonas aeruginosa NAD kinase by Rahimova, Rahila, Nogaret, Pauline, Huteau, Valérie, Gelin, Muriel, Clément, David A., Labesse, Gilles, Pochet, Sylvie, Blanc‐Potard, Anne‐Béatrice, Lionne, Corinne

“…Multidrug resistance is a major public health problem that requires the urgent development of new antibiotics and therefore the identification of novel…”
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Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation by Labesse, Gilles, Alexandre, Thomas, Gelin, Muriel, Haouz, Ahmed, Munier-Lehmann, Hélène

“…Inosine‐5′‐monophosphate dehydrogenases (IMPDHs), which are the rate‐limiting enzymes in guanosine‐nucleotide biosynthesis, are important therapeutic targets…”
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